scholarly journals Cathepsin C limits acute viral infection independently of NK cell and CD8 + T‐cell cytolytic function

2010 ◽  
Vol 89 (4) ◽  
pp. 540-548 ◽  
Author(s):  
Christopher E Andoniou ◽  
Peter Fleming ◽  
Vivien R Sutton ◽  
Joseph A Trapani ◽  
Mariapia A Degli‐Esposti
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Nk Cell ◽  
Cd8 T Cell ◽  
Cathepsin C ◽  
Cytolytic Function ◽  
Acute Viral Infection

The Methylcytosine Dioxygenase TET2 Regulates CD8+ T Cell Memory Differentiation

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 3692-3692
Author(s):  
Shannon A. Carty ◽  
Mercy Gohil ◽  
Lauren B. Banks ◽  
Matthew E Johnson ◽  
Erietta Stelekati ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Viral Infection ◽  
Cell Fate ◽  
Cd8 T Cell ◽  
T Cell Differentiation ◽  
T Cell Memory ◽  
Acute Viral Infection ◽  
Memory Differentiation ◽  
Cd8 T Cell Memory

Abstract DNA methylation is one of the major epigenetic mechanisms that control T cell differentiation. The ten-eleven translocation (TET) family of methylcytosine dioxygenases converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and other oxidized methylcytosines, intermediates in active DNA demethylation. Here we demonstrate that TET2 regulates CD8+ T cell differentiation in vivo following acute viral infection. At steady-state, mice with a T-cell specific deletion of TET2 have intact thymic and peripheral T cell populations. However, following acute viral infection with LCMV-Armstrong, TET2 loss promotes early acquisition of a memory CD8+ T cell fate in a cell-intrinsic manner without disrupting antigen-driven cell expansion or effector function. Integration of genome-wide methylation analysis and expression data suggest that TET2 loss leads to hypermethyation of the PRDM1 genomic locus (encoding Blimp-1) and alters the relative expression of Blimp-1 and Bcl-6, two antagonistic transcriptional repressors known to direct CD8+ T cell memory differentiation. Together, our data indicate that TET2 is an important regulator of CD8+ T cell fate decisions. Disclosures No relevant conflicts of interest to declare.

scholarly journals IL-21 Deficiency Influences CD8 T Cell Quality and Recall Responses following an Acute Viral Infection

2010 ◽  
Vol 185 (8) ◽  
pp. 4835-4845 ◽  
Author(s):  
John S. Yi ◽  
Jennifer T. Ingram ◽  
Allan J. Zajac
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cell ◽  
Acute Viral Infection

scholarly journals Acute and Chronic B Cell Depletion Disrupts CD4+and CD8+T Cell Homeostasis and Expansion during Acute Viral Infection in Mice

2014 ◽  
Vol 193 (2) ◽  
pp. 746-756 ◽  
Author(s):  
Jacquelyn M. Lykken ◽  
David J. DiLillo ◽  
Eric T. Weimer ◽  
Susanne Roser-Page ◽  
Mark T. Heise ◽  
...  
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
B Cell ◽  
Cd8 T Cell ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Acute Viral Infection

scholarly journals Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection

2009 ◽  
Vol 206 (10) ◽  
pp. 2235-2251 ◽  
Author(s):  
Seung-Hwan Lee ◽  
Kwang-Sin Kim ◽  
Nassima Fodil-Cornu ◽  
Silvia M. Vidal ◽  
Christine A. Biron
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Viral Infection ◽  
Nk Cells ◽  
Cell Expansion ◽  
Nk Cell ◽  
Cd8 T Cell ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Activating Receptors

Natural killer (NK) cells have the potential to deliver both direct antimicrobial effects and regulate adaptive immune responses, but NK cell yields have been reported to vary greatly during different viral infections. Activating receptors, including the Ly49H molecule recognizing mouse cytomegalovirus (MCMV), can stimulate NK cell expansion. To define Ly49H's role in supporting NK cell proliferation and maintenance under conditions of uncontrolled viral infection, experiments were performed in Ly49h−/−, perforin 1 (Prf1)−/−, and wild-type (wt) B6 mice. NK cell numbers were similar in uninfected mice, but relative to responses in MCMV-infected wt mice, NK cell yields declined in the absence of Ly49h and increased in the absence of Prf1, with high rates of proliferation and Ly49H expression on nearly all cells. The expansion was abolished in mice deficient for both Ly49h and Prf1 (Ly49h−/−Prf1−/−), and negative consequences for survival were revealed. The Ly49H-dependent protection mechanism delivered in the absence of Prf1 was a result of interleukin 10 production, by the sustained NK cells, to regulate the magnitude of CD8 T cell responses. Thus, the studies demonstrate a previously unappreciated critical role for activating receptors in keeping NK cells present during viral infection to regulate adaptive immune responses.

scholarly journals NK cell–intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection

2019 ◽  
Vol 15 (6) ◽  
pp. e1007797 ◽  
Author(s):  
Vikas Duhan ◽  
Thamer A. Hamdan ◽  
Haifeng C. Xu ◽  
Prashant Shinde ◽  
Hilal Bhat ◽  
...  
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Cell Expansion ◽  
Nk Cell ◽  
Cd8 T Cell ◽  
Chronic Viral Infection ◽  
T Cell Expansion

scholarly journals Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection

2010 ◽  
Vol 185 (9) ◽  
pp. 5315-5325 ◽  
Author(s):  
Yong Woo Jung ◽  
Rachel L. Rutishauser ◽  
Nikhil S. Joshi ◽  
Ann M. Haberman ◽  
Susan M. Kaech
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cell ◽  
Lymphoid Organs ◽  
T Cell Subsets ◽  
Acute Viral Infection ◽  
Differential Localization ◽  
Memory Cd8 T Cell

scholarly journals Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection

2005 ◽  
Vol 201 (7) ◽  
pp. 1053-1059 ◽  
Author(s):  
Jason K. Whitmire ◽  
Joyce T. Tan ◽  
J. Lindsay Whitton
Keyword(s):  
T Cells ◽  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Interferon Γ ◽  
Current Evidence ◽  
Cell Responses ◽  
Acute Viral Infection

Interferon-γ (IFNγ) is important in regulating the adaptive immune response, and most current evidence suggests that it exerts a negative (proapoptotic) effect on CD8+ T cell responses. We have developed a novel technique of dual adoptive transfer, which allowed us to precisely compare, in normal mice, the in vivo antiviral responses of two T cell populations that differ only in their expression of the IFNγ receptor. We use this technique to show that, contrary to expectations, IFNγ strongly stimulates the development of CD8+ T cell responses during an acute viral infection. The stimulatory effect is abrogated in T cells lacking the IFNγ receptor, indicating that the cytokine acts directly upon CD8+ T cells to increase their abundance during acute viral infection.

scholarly journals IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection

2010 ◽  
Vol 107 (7) ◽  
pp. 3018-3023 ◽  
Author(s):  
D. G. Brooks ◽  
K. B. Walsh ◽  
H. Elsaesser ◽  
M. B. A. Oldstone
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cell ◽  
Acute Viral Infection ◽  
Cell Effector

scholarly journals Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection

Virology ◽  
2016 ◽  
Vol 490 ◽  
pp. 75-82 ◽  
Author(s):  
Eui Ho Kim ◽  
Brandon Neldner ◽  
Jingang Gui ◽  
Ruth W. Craig ◽  
M. Suresh
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cell ◽  
T Cell Differentiation ◽  
Acute Viral Infection ◽  
Memory Cd8 T Cell
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