scholarly journals Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection

2010 ◽  
Vol 185 (9) ◽  
pp. 5315-5325 ◽  
Author(s):  
Yong Woo Jung ◽  
Rachel L. Rutishauser ◽  
Nikhil S. Joshi ◽  
Ann M. Haberman ◽  
Susan M. Kaech
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cell ◽  
Lymphoid Organs ◽  
T Cell Subsets ◽  
Acute Viral Infection ◽  
Differential Localization ◽  
Memory Cd8 T Cell

scholarly journals Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection

Virology ◽  
2016 ◽  
Vol 490 ◽  
pp. 75-82 ◽  
Author(s):  
Eui Ho Kim ◽  
Brandon Neldner ◽  
Jingang Gui ◽  
Ruth W. Craig ◽  
M. Suresh
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cell ◽  
T Cell Differentiation ◽  
Acute Viral Infection ◽  
Memory Cd8 T Cell

scholarly journals Impact of multiple hits with cognate antigen on memory CD8+ T-cell fate

2020 ◽  
Vol 32 (9) ◽  
pp. 571-581 ◽  
Author(s):  
Shiki Takamura
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Memory T Cells ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Primary Immune Response ◽  
Memory T Cell ◽  
Cognate Antigen ◽  
Memory Cd8 T Cell

Abstract Antigen-driven activation of CD8+ T cells results in the development of a robust anti-pathogen response and ultimately leads to the establishment of long-lived memory T cells. During the primary response, CD8+ T cells interact multiple times with cognate antigen on distinct types of antigen-presenting cells. The timing, location and context of these antigen encounters significantly impact the differentiation programs initiated in the cells. Moderate re-activation in the periphery promotes the establishment of the tissue-resident memory T cells that serve as sentinels at the portal of pathogen entry. Under some circumstances, moderate re-activation of T cells in the periphery can result in the excessive expansion and accumulation of circulatory memory T cells, a process called memory inflation. In contrast, excessive re-activation stimuli generally impede conventional T-cell differentiation programs and can result in T-cell exhaustion. However, these conditions can also elicit a small population of exhausted T cells with a memory-like signature and self-renewal capability that are capable of responding to immunotherapy, and restoration of functional activity. Although it is clear that antigen re-encounter during the primary immune response has a significant impact on memory T-cell development, we still do not understand the molecular details that drive these fate decisions. Here, we review our understanding of how antigen encounters and re-activation events impact the array of memory CD8+ T-cell subsets subsequently generated. Identification of the molecular programs that drive memory T-cell generation will advance the development of new vaccine strategies that elicit high-quality CD8+ T-cell memory.

The Methylcytosine Dioxygenase TET2 Regulates CD8+ T Cell Memory Differentiation

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 3692-3692
Author(s):  
Shannon A. Carty ◽  
Mercy Gohil ◽  
Lauren B. Banks ◽  
Matthew E Johnson ◽  
Erietta Stelekati ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Viral Infection ◽  
Cell Fate ◽  
Cd8 T Cell ◽  
T Cell Differentiation ◽  
T Cell Memory ◽  
Acute Viral Infection ◽  
Memory Differentiation ◽  
Cd8 T Cell Memory

Abstract DNA methylation is one of the major epigenetic mechanisms that control T cell differentiation. The ten-eleven translocation (TET) family of methylcytosine dioxygenases converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and other oxidized methylcytosines, intermediates in active DNA demethylation. Here we demonstrate that TET2 regulates CD8+ T cell differentiation in vivo following acute viral infection. At steady-state, mice with a T-cell specific deletion of TET2 have intact thymic and peripheral T cell populations. However, following acute viral infection with LCMV-Armstrong, TET2 loss promotes early acquisition of a memory CD8+ T cell fate in a cell-intrinsic manner without disrupting antigen-driven cell expansion or effector function. Integration of genome-wide methylation analysis and expression data suggest that TET2 loss leads to hypermethyation of the PRDM1 genomic locus (encoding Blimp-1) and alters the relative expression of Blimp-1 and Bcl-6, two antagonistic transcriptional repressors known to direct CD8+ T cell memory differentiation. Together, our data indicate that TET2 is an important regulator of CD8+ T cell fate decisions. Disclosures No relevant conflicts of interest to declare.

scholarly journals IL-21 Deficiency Influences CD8 T Cell Quality and Recall Responses following an Acute Viral Infection

2010 ◽  
Vol 185 (8) ◽  
pp. 4835-4845 ◽  
Author(s):  
John S. Yi ◽  
Jennifer T. Ingram ◽  
Allan J. Zajac
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cell ◽  
Acute Viral Infection

scholarly journals Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life

2009 ◽  
Vol 130 (3) ◽  
pp. 280-289 ◽  
Author(s):  
Nazma Mansoor ◽  
Brian Abel ◽  
Thomas J. Scriba ◽  
Jane Hughes ◽  
Marwou de Kock ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
First Year ◽  
Memory Cd8 T Cell ◽  
First Year Of Life ◽  
Hiv 1

scholarly journals Acute and Chronic B Cell Depletion Disrupts CD4+and CD8+T Cell Homeostasis and Expansion during Acute Viral Infection in Mice

2014 ◽  
Vol 193 (2) ◽  
pp. 746-756 ◽  
Author(s):  
Jacquelyn M. Lykken ◽  
David J. DiLillo ◽  
Eric T. Weimer ◽  
Susanne Roser-Page ◽  
Mark T. Heise ◽  
...  
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
B Cell ◽  
Cd8 T Cell ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Acute Viral Infection

scholarly journals Altered representation of naive and memory CD8 T cell subsets in HIV-infected children.

1995 ◽  
Vol 95 (5) ◽  
pp. 2054-2060 ◽  
Author(s):  
R L Rabin ◽  
M Roederer ◽  
Y Maldonado ◽  
A Petru ◽  
L A Herzenberg ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Memory Cd8 T Cell
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