scholarly journals Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension

2009 ◽  
Vol 32 (8) ◽  
pp. 670-674 ◽  
Author(s):  
Takayoshi Tsutamoto ◽  
Toshinari Tanaka ◽  
Keizo Nishiyama ◽  
Masayuki Yamaji ◽  
Chiho Kawahara ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Plasma Aldosterone ◽  
Term Effect ◽  
Ventricular Mass Index ◽  
Ventricular Mass ◽  
Long Term Effect

scholarly journals Association Between AGT M235T and Left Ventricular Mass in Vietnamese Patients Diagnosed With Essential Hypertension

2021 ◽  
Vol 8 ◽  
Author(s):  
Tuan Thanh Tran ◽  
Thao Phuong Mai ◽  
Ha Chau Bich Tran ◽  
Linh Hoang Gia Le ◽  
Hoang Anh Vu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Ventricular Mass Index ◽  
Independent Prognostic Marker ◽  
Asian Populations ◽  
Ventricular Mass ◽  
2D Echocardiography

Background: Increasing left ventricular mass in hypertensive patients is an independent prognostic marker for adverse cardiovascular outcomes. Genetic factors have been shown to critically affect left ventricular mass. AGT M235T is one of the genetic polymorphisms that may influence left ventricular mass due to its pivotal role in the regulation of plasma angiotensinogen level as well as hypertension pathophysiology in Asian populations. Currently, how M235T affects left ventricular mass is not well-described in Vietnamese hypertensive patients. This study aimed to investigate the association between M235T and left ventricular mass in Vietnamese patients diagnosed with essential hypertension.Materials and Methods:AGT M235T genotyping and 2D echocardiography were performed on 187 Vietnamese subjects with essential hypertension. All the ultrasound parameters were obtained to calculate the left ventricular mass index according to the American Society of Echocardiography and the European Association of Cardiovascular Imaging 2015 guidelines. Other clinical characteristics were also recorded, including age, gender, duration of hypertension, hypertensive treatment, lifestyle, renal function, fasting plasma glucose, and lipid profile.Results: MT and TT genotypes were determined in 30 and 157 subjects, respectively. AGT M235T genotype, duration of hypertension, body mass index, and ejection fraction statistically affected the left ventricular mass index, which was significantly greater in TT compared to MT carriers after adjusting for confounding factors.Conclusion: The TT genotype of AGT M23T was associated with greater left ventricular mass in Vietnamese patients diagnosed with essential hypertension.

scholarly journals Study of the correlation of epicardial adipose tissue with left ventricular mass and left ventricular mass index in patients with essential hypertension

2020 ◽  
Vol 8 (2) ◽  
pp. 686
Author(s):  
Sourabh Goswami ◽  
Prakash Keswani ◽  
Neeraj Chaturvedi ◽  
Shrikant Sharma ◽  
Ramji Sharma
Keyword(s):  
Adipose Tissue ◽  
Essential Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Epicardial Adipose Tissue ◽  
Left Ventricular ◽  
Cardiovascular Outcome ◽  
Spearman Correlation ◽  
Ventricular Mass Index ◽  
Ventricular Mass

Background: Epicardial Adipose Tissue (EAT) is recognized to be a cardiovascular risk factor. In addition to providing fuel to heart, it plays a pivotal role in the pathogenesis of atherosclerosis though the secretion of adipokines. This study aims to find the correlation of EAT with Left Ventricular Mass (LVM) and Left Ventricular Mass Index (LVMI) in patients with essential hypertension. Increasing LVM and LVMI are predictors of poor cardiovascular outcome. So, if we find a positive correlation, we can say that measurement of epicardial fat in essential hypertension may help us identify high risk hypertensive patients.Methods: This study was carried out in SMS Hospital, Jaipur, after approval from the Ethics Committee. 100 consecutive eligible patients were included in the study after application of inclusion and exclusion criteria and taking proper informed consent. After history, examination and routine laboratory investigations, all patients underwent transthoracic 2D and Doppler echocardiography. EAT thickness, LVM and LVMI were measured and correlated using Spearman correlation coefficient.Results: The mean LVM was 139±42.12 g and mean LVMI was 35.76±11.28 g/m2.7. The spearman correlation coefficient (r) was calculated to be 0.691 between EAT and LVM and 0.677 between EAT and LVMI, indicating strong positive correlation between EAT and both LVM and LVMI. This implies that as; EAT increases, LVM and LVMI increases significantly.Conclusions: Thus, authors have found that EAT is positively correlated with LVM and LVMI. So, we can say that increase in EAT may lead to adverse cardiovascular outcome in patients with essential hypertension.

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