scholarly journals Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject

2009 ◽  
Vol 32 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Namiko Ochi ◽  
Yasuharu Tabara ◽  
Michiya Igase ◽  
Tokihisa Nagai ◽  
Tomoko Kido ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Healthy Subject ◽  
Cerebral Microbleeds ◽  
Apparently Healthy

scholarly journals Carotid Arterial Stiffness and Risk of Incident Cerebral Microbleeds in Older People

2015 ◽  
Vol 35 (8) ◽  
pp. 1889-1895 ◽  
Author(s):  
Jie Ding ◽  
Gary F. Mitchell ◽  
Michiel L. Bots ◽  
Sigurdur Sigurdsson ◽  
Tamara B. Harris ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Older People ◽  
Cerebral Microbleeds ◽  
Carotid Arterial

scholarly journals Cerebral Microbleeds and White Matter Hyperintensities in Cognitively Healthy Elderly: A Cross-Sectional Cohort Study Evaluating the Effect of Arterial Stiffness

2015 ◽  
Vol 5 (2) ◽  
pp. 41-51 ◽  
Author(s):  
Anna-Märta Gustavsson ◽  
Erik Stomrud ◽  
Kasim Abul-Kasim ◽  
Lennart Minthon ◽  
Peter M. Nilsson ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Arterial Stiffness ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
Cerebral Microbleeds ◽  
Small Vessel ◽  
Cognitive Tests ◽  
Vessel Disease ◽  
Healthy Elderly

Background: Arterial stiffness reflects the ageing processes in the vascular system, and studies have shown an association between reduced cognitive function and cerebral small vessel disease. Small vessel disease can be visualized as white matter hyperintensities (WMH) and lacunar infarcts but also as cerebral microbleeds on brain magnetic resonance imaging (MRI). We aimed to investigate if arterial stiffness influences the presence of microbleeds, WMH and cognitive function in a population of cognitively healthy elderly. Methods: The study population is part of the Swedish BioFinder study and consisted of 208 individuals without any symptoms of cognitive impairment, who scored >27 points on the Mini-Mental State Examination. The participants (mean age, 72 years; 59% women) underwent MRI of the brain with visual rating of microbleeds and WMH. Arterial stiffness was measured with carotid-femoral pulse wave velocity (cfPWV). Eight cognitive tests covering different cognitive domains were performed. Results: Microbleeds were detected in 12% and WMH in 31% of the participants. Mean (±standard deviation, SD) cfPWV was 10.0 (±2.0) m/s. There was no association between the presence of microbleeds and arterial stiffness. There was a positive association between arterial stiffness and WMH independent of age or sex (odds ratio, 1.58; 95% confidence interval, 1.04-2.40, p < 0.05), but the effect was attenuated when further adjustments for several cardiovascular risk factors were performed (p > 0.05). Cognitive performance was not associated with microbleeds, but individuals with WMH performed slightly worse than those without WMH on the Symbol Digit Modalities Test (mean ± SD, 35 ± 7.8 vs. 39 ± 8.1, p < 0.05). Linear regression revealed no direct associations between arterial stiffness and the results of the cognitive tests. Conclusions: Arterial stiffness was not associated with the presence of cerebral microbleeds or cognitive function in cognitively healthy elderly. However, arterial stiffness was related to the presence of WMH, but the association was attenuated when multiple adjustments were made. There was a weak negative association between WMH and performance in one specific test of attention. Longitudinal follow-up studies are needed to further assess the associations.

Cerebral Microbleeds Are Independently Associated with Arterial Stiffness in Stroke Patients

2008 ◽  
Vol 26 (6) ◽  
pp. 618-623 ◽  
Author(s):  
Woo-Keun Seo ◽  
Jong-Moon Lee ◽  
Moon Ho Park ◽  
Kun Woo Park ◽  
Dae Hie Lee
Keyword(s):  
Arterial Stiffness ◽  
Cerebral Microbleeds ◽  
Stroke Patients

scholarly journals Relationship between arterial stiffness and heart rate recovery in apparently healthy adults

2005 ◽  
Vol 1 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Ding-Yu Fei ◽  
Ross Arena ◽  
James A Arrowood ◽  
Kenneth A Kraft
Keyword(s):  
Heart Rate ◽  
Arterial Stiffness ◽  
Heart Rate Recovery ◽  
Healthy Adults ◽  
Apparently Healthy

scholarly journals Self-reported Sleep Habits Are Related To Arterial Stiffness In Apparently Healthy Individuals

2020 ◽  
Vol 52 (7S) ◽  
pp. 902-902
Author(s):  
Meral N. Culver ◽  
Sean P. Langan ◽  
Bryan L. Riemann ◽  
Andrew A. Flatt ◽  
Gregory J. Grosicki
Keyword(s):  
Arterial Stiffness ◽  
Healthy Individuals ◽  
Sleep Habits ◽  
Apparently Healthy

scholarly journals Epidemiology of microsporidia infection among apparently healthy subject and immunocompromised patients in Minna

2019 ◽  
Vol 4 (2) ◽  
pp. 36-42
Author(s):  
E. Ubanwa ◽  
◽  
I. C. J. Omalu ◽  
I. K. Olayemi ◽  
I. A. A. Ejima ◽  
...  
Keyword(s):  
Healthy Subject ◽  
Immunocompromised Patients ◽  
Apparently Healthy

Abstract WMP82: The Association Between Cerebral Microbleeds And Arterial Stiffness

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Tae-Jin Song ◽  
Jinkwon Kim ◽  
Dong-Beom Song ◽  
Hye Sun Lee ◽  
Chung Mo Nam ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Multinomial Logistic Regression ◽  
Univariate Analysis ◽  
Ankle Brachial Index ◽  
Automatic Device ◽  
Cerebral Microbleeds ◽  
P Value ◽  
Amyloid Angiopathy ◽  
Small Vessels ◽  
Logistic Analysis

Background and significance: Increased arterial stiffness causes vessel damage of the end-organs. Thus, in the brain, small vessels may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically categorized as non-lobar type, mostly due to hypertensive vasculopathy and lobar type, due to cerebral amyloid angiopathy. When considering CMBs in the nonlobar region are associated with small vessel pathology, arterial stiffness may be related with CMBs in the nonlobar region. We investigated relationship between CMBs by using brachial ankle pulse wave velocity (baPWV) representing arterial stiffness. Method: Between June 2006 and January 2012, we included 1290 consecutive patients with acute ischemic stroke admitted to hospital within 7 days after symptom onset and who underwent baPWV and brain gradient echo (GRE) and Fluid Attenuated Inversion Recovery (FLAIR) MRI. Patients with potential cardiac sources of embolism or peripheral arterial occlusive disease were not included. BaPWV was measured during ankle-brachial index examination using an automatic device. CMBs were classified as lobar and nonlobar type. Severity of leukoaraiosis was determined using the Fazekas’ scoring system. Binary and multinomial logistic regression analyses were performed to determine variables that were associated with presence and location of CMBs. Results: Mean age of the patients was 64±12 years and 61.9% (799/1290) were male. Of 1290 patients, CMBs were found in 28.6%. The patients with CMBs were older than those without CMBs (69±10 years versus 63±12 years, p=0.001). Mean baPWV was higher in patients with CMBs than those without (2240±512cm/s versus 1896±505cm/s, p=0.001). On multivariate binary logistic analysis, baPWV and high grade leukoaraiosis were independent predictors of the presence of CMBs. However, after adjustment of age, sex and variables with p value of less than 0.1on the univariate analysis, baPWV was independently associated with nonlobar CMBs. Conclusion: Arterial stiffness was independently associated with nonlobar CMBs but not with lobar CMBs. These findings suggest pathophysiologic association between arterial stiffness and CMBs in the nonlobar region.

Sign in / Sign up

Export Citation Format

Share Document