scholarly journals Association between central systolic blood pressure, white matter lesions in cerebral MRI and carotid atherosclerosis

2009 ◽  
Vol 32 (10) ◽  
pp. 869-874 ◽  
Author(s):  
Isha Shrestha ◽  
Tetsuya Takahashi ◽  
Eiichi Nomura ◽  
Toshiho Ohtsuki ◽  
Tomohiko Ohshita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Systolic Blood Pressure ◽  
Carotid Atherosclerosis ◽  
White Matter Lesions ◽  
Cerebral Mri ◽  
Central Systolic Blood Pressure

scholarly journals Variability in Midlife Systolic Blood Pressure Is Related to Late-Life Brain White Matter Lesions

Stroke ◽  
2002 ◽  
Vol 33 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Richard J. Havlik ◽  
Daniel J. Foley ◽  
Bryan Sayer ◽  
Kamal Masaki ◽  
Lon White ◽  
...  
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Systolic Blood Pressure ◽  
White Matter Lesions ◽  
Late Life ◽  
Brain White Matter

Prevention of White-Matter Lesions Through Control of Cerebrovascular Risk Factors

2003 ◽  
Vol 15 (S1) ◽  
pp. 147-151 ◽  
Author(s):  
Charles DeCarli
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Systolic Blood Pressure ◽  
Strong Association ◽  
Treatment Strategies ◽  
White Matter Lesions ◽  
Elevated Blood Pressure ◽  
Cerebral White Matter ◽  
Elevated Blood ◽  
Atherosclerotic Vascular Disease

Multiple epidemiological and brain imaging studies show a strong association between elevations in systolic blood pressure and lesions of cerebral white matter. The association between white-matter lesions and systolic blood pressure persists even if individuals are receiving treatment, suggesting that these individuals may be undertreated. In addition, these studies suggest that lesions of cerebral white matter may serve as markers for atherosclerotic vascular disease. Treatment strategies, therefore, should focus on early and aggressive management of elevated blood pressure, but definitions of elevated blood pressure may need to be revised downward to achieve best results.

White matter hyperintensities in migraine: Clinical significance and central pulsatile hemodynamic correlates

Cephalalgia ◽  
2017 ◽  
Vol 38 (7) ◽  
pp. 1225-1236 ◽  
Author(s):  
Chun-Yu Cheng ◽  
Hao-Min Cheng ◽  
Shih-Pin Chen ◽  
Chih-Ping Chung ◽  
Yung-Yang Lin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Pulse Wave Velocity ◽  
Systolic Blood Pressure ◽  
Wave Velocity ◽  
Pulsatility Index ◽  
White Matter Hyperintensities ◽  
Pulse Wave ◽  
Healthy Controls ◽  
Central Systolic Blood Pressure

Background The role of central pulsatile hemodynamics in the pathogenesis of white matter hyperintensities in migraine patients has not been clarified. Methods Sixty patients with migraine (20–50 years old; women, 68%) without overt vascular risk factors and 30 demographically-matched healthy controls were recruited prospectively. Cerebral white matter hyperintensities volume was determined by T1-weighted magnetic resonance imaging with CUBE-fluid-attenuated-inversion-recovery sequences. Central systolic blood pressure, carotid-femoral pulse wave velocity, and carotid augmentation index were measured by applanation tonometry. Carotid pulsatility index was derived from Doppler ultrasound carotid artery flow analysis. Results Compared to the controls, the migraine patients had higher white matter hyperintensities frequency (odds ratio, 2.75; p = 0.04) and greater mean white matter hyperintensities volume (0.174 vs. 0.049, cm3, p = 0.04). Multivariable regression analysis showed that white matter hyperintensities volume in migraine patients was positively associated with central systolic blood pressure ( p = 0.04) and carotid-femoral pulse wave velocity ( p < 0.001), but negatively associated with carotid pulsatility index ( p = 0.04) after controlling for potential confounding factors. The interaction effects observed indicated that the influence of carotid-femoral pulse wave velocity ( p = 0.004) and central systolic blood pressure ( p = 0.03) on white matter hyperintensities formation was greater for the lower-carotid pulsatility index subgroup of migraine patients. White matter hyperintensities volume in migraine patients increased with decreasing carotid pulsatility index and with increasing central systolic blood pressure or carotid-femoral pulse wave velocity. Conclusions White matter hyperintensities are more common in patients with migraine than in healthy controls. Increased aortic stiffness or central systolic blood pressure in the presence of low intracranial artery resistance may predispose patients with migraine to white matter hyperintensities formation.

scholarly journals Post-Exertional Malaise May Be Related to Central Blood Pressure, Sympathetic Activity and Mental Fatigue in Chronic Fatigue Syndrome Patients

2021 ◽  
Vol 10 (11) ◽  
pp. 2327
Author(s):  
Sławomir Kujawski ◽  
Joanna Słomko ◽  
Lynette Hodges ◽  
Derek F. H. Pheby ◽  
Modra Murovska ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Chronic Fatigue Syndrome ◽  
Systolic Blood Pressure ◽  
Sympathetic Activity ◽  
Chronic Fatigue ◽  
Mental Fatigue ◽  
Fatigue Syndrome ◽  
Central Systolic Blood Pressure

Post-exertional malaise (PEM) is regarded as the hallmark symptom in chronic fatigue syndrome (CFS). The aim of the current study is to explore differences in CFS patients with and without PEM in indicators of aortic stiffness, autonomic nervous system function, and severity of fatigue. One-hundred and one patients met the Fukuda criteria. A Chronic Fatigue Questionnaire (CFQ) and Fatigue Impact Scale (FIS) were used to assess the level of mental and physical fatigue. Aortic systolic blood pressure (sBPaortic) and the autonomic nervous system were measured with the arteriograph and Task Force Monitor, respectively. Eighty-two patients suffered prolonged PEM according to the Fukuda criteria, while 19 did not. Patients with PEM had higher FIS scores (p = 0.02), lower central systolic blood pressure (p = 0.02) and higher mental fatigue (p = 0.03). For a one-point increase in the mental fatigue component of the CFQ scale, the risk of PEM increases by 34%. For an sBPaortic increase of 1 mmHg, the risk of PEM decreases by 5%. For a one unit increase in sympathovagal balance, the risk of PEM increases by 330%. Higher mental fatigue and sympathetic activity in rest are related to an increased risk of PEM, while higher central systolic blood pressure is related to a reduced risk of PEM. However, none of the between group differences were significant after FDR correction, and therefore conclusions should be treated with caution and replicated in further studies.

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