Verteporfin therapy in occult with no classic CNV due to AMD: results of the Photodynamic Therapy in Occult-Only Lesions study

In this chapter, report 1 of the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) study details the one-year results of two double-masked, placebo-controlled, randomized clinical trials to determine whether photodynamic treatment with verteporfin reduces the risk of vision loss in patients with age-related macular degeneration (AMD) due to subfoveal choroidal neovascularization (CNV) measuring 5400 µm or less in greatest linear dimension with evidence of classic CNV and best-corrected visual acuity of approximately 20/40 to 20/200. At the month-12 examination, 61% of eyes assigned to verteporfin compared with 46% of eyes assigned to placebo had lost fewer than 15 letters of visual acuity from baseline). Verteporfin therapy was found to be safe and effective in reducing the risk of vision loss, and the authors recommended verteporfin therapy for treatment of patients with predominantly classic CNV from AMD.

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Photodynamic Therapy

10.1039/9781847551658 ◽

2003 ◽

Cited By ~ 29

Keyword(s):

Photodynamic Therapy

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Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽

10.1039/c9nr10453d ◽

2020 ◽

Vol 12 (14) ◽

pp. 7875-7887 ◽

Cited By ~ 2

Author(s):

Ying Lan ◽

Xiaohui Zhu ◽

Ming Tang ◽

Yihan Wu ◽

Jing Zhang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Near Infrared ◽

Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

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Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

Polymer Chemistry ◽

10.1039/c9py01391a ◽

2019 ◽

Vol 10 (45) ◽

pp. 6116-6121 ◽

Cited By ~ 3

Author(s):

Tan Ji ◽

Lei Xia ◽

Wei Zheng ◽

Guang-Qiang Yin ◽

Tao Yue ◽

...

Keyword(s):

Photodynamic Therapy ◽

Self Assembly ◽

Star Polymers ◽

New Family ◽

Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

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A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

Chemical Communications ◽

10.1039/d0cc02019b ◽

2020 ◽

Vol 56 (43) ◽

pp. 5819-5822

Author(s):

Jing Zheng ◽

Yongzhuo Liu ◽

Fengling Song ◽

Long Jiao ◽

Yingnan Wu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Triplet State ◽

Near Infrared ◽

Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

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Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

Dalton Transactions ◽

10.1039/d0dt02424d ◽

2020 ◽

Vol 49 (33) ◽

pp. 11583-11590 ◽

Cited By ~ 2

Author(s):

Zheng-Yin Pan ◽

Dai-Hong Cai ◽

Liang He

Keyword(s):

Photodynamic Therapy ◽

Cell Apoptosis ◽

Lysosomal Dysfunction ◽

Intracellular Ros

Two dinuclear organometallic Re(i) complexes increase intracellular ROS levels, causing lysosomal dysfunction and cell apoptosis.

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Involvement of CFTR in photodynamic therapy-mediated apoptosis

Cell Biology International ◽

10.1042/cbi034s044a ◽

2010 ◽

Vol 34 (8) ◽

pp. S44-S44

Author(s):

Juan Juan Chen ◽

Xiao Hua Jiang ◽

Hsiao Chang Chan

Keyword(s):

Photodynamic Therapy

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