scholarly journals Pathogenicity and transmission of a swine influenza A(H6N6) virus

2017 ◽  
Vol 6 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Hailiang Sun ◽  
Bryan S Kaplan ◽  
Minhui Guan ◽  
Guihong Zhang ◽  
Jianqiang Ye ◽  
...  
Keyword(s):  
Influenza A ◽  
Swine Influenza ◽  
H6n6 Virus

scholarly journals Swine influenza A virus subtypes circulating in Brazilian commercial pig herds from 2012 to 2019

2021 ◽  
Author(s):  
Ana Luiza Soares Fraiha ◽  
Ana Carolina Diniz Matos ◽  
João Luis Reis Cunha ◽  
Beatriz Senra Álvares da Silva Santos ◽  
Maria Vitória Chaves Peixoto ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Swine Influenza A Virus

Swine influenza vaccines: current status and future perspectives

2010 ◽  
Vol 11 (1) ◽  
pp. 81-96 ◽  
Author(s):  
Wenjun Ma ◽  
Jürgen A. Richt
Keyword(s):  
Influenza A ◽  
Swine Influenza ◽  
Influenza Viruses ◽  
Current Status ◽  
Economic Losses ◽  
Influenza A Viruses ◽  
Swine Industry ◽  
Effective Strategies ◽  
Swine Disease ◽  
And Control

AbstractSwine influenza is an important contagious disease in pigs caused by influenza A viruses. Although only three subtypes of influenza A viruses, H1N1, H1N2 and H3N2, predominantly infect pigs worldwide, it is still a big challenge for vaccine manufacturers to produce efficacious vaccines for the prevention and control of swine influenza. Swine influenza viruses not only cause significant economic losses for the swine industry, but are also important zoonotic pathogens. Vaccination is still one of the most important and effective strategies to prevent and control influenza for both the animal and human population. In this review, we will discuss the current status of swine influenza worldwide as well as current and future options to control this economically important swine disease.

scholarly journals Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine

2018 ◽  
Vol 14 (12) ◽  
pp. e1007417 ◽  
Author(s):  
Xiaojian Zhang ◽  
Hailiang Sun ◽  
Fred L. Cunningham ◽  
Lei Li ◽  
Katie Hanson-Dorr ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Tissue Tropisms ◽  
Swine Influenza A Virus

Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza

Science ◽  
1976 ◽  
Vol 194 (4262) ◽  
pp. 334-335 ◽  
Author(s):  
P Palese ◽  
M. Ritchey ◽  
J. Schulman ◽  
E. Kilbourne
Keyword(s):  
Influenza A Virus ◽  
Vaccine Strain ◽  
Influenza A ◽  
Swine Influenza ◽  
Genetic Composition ◽  
Virus Recombinant

scholarly journals Bat influenza vectored NS1-truncated live vaccine protects pigs against heterologous virus challenge

2020 ◽  
Author(s):  
Jinhwa Lee ◽  
Yonghai Li ◽  
Yuhao Li ◽  
A. Giselle Cino-Ozuna ◽  
Michael Duff ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Live Vaccine ◽  
H3n2 Virus ◽  
Swine Industry ◽  
Vaccine Candidates ◽  
Virus Challenge ◽  
Significant Difference

AbstractSwine influenza is an important disease for the swine industry. Currently used whole inactivated virus (WIV) vaccines can induce vaccine-associated enhanced respiratory disease (VAERD) in pigs when the vaccine strains mismatch with the infected viruses. Live attenuated influenza virus vaccine (LAIV) is effective to protect pigs against homologous and heterologous swine influenza virus infections without inducing VAERD, but has safety concerns due to potential reassortment with circulating viruses. Herein, we used a chimeric bat influenza Bat09:mH3mN2 virus, which contains both surface HA and NA gene open reading frames of the A/swine/Texas/4199-2/1998 (H3N2) and six internal genes from the novel bat H17N10 virus, to develop modified live-attenuated viruses (MLVs) as vaccine candidates which cannot reassort with canonical influenza A viruses by co-infection. Two attenuated MLV vaccine candidates including the virus that expresses a truncated NS1 (Bat09:mH3mN2-NS1-128, MLV1) or expresses both a truncated NS1 and the swine IL-18 (Bat09:mH3mN2-NS1-128-IL-18, MLV2) were generated and evaluated in pigs against a heterologous H3N2 virus using the WIV vaccineb as a control. Compared to the WIV vaccine, both MLV vaccines were able to reduce lesions and virus replication in lungs and limit nasal virus shedding without VAERD, also induced significantly higher levels of mucosal IgA response in lungs and significantly increased numbers of antigen-specific IFN-γ secreting cells against the challenge virus. However, no significant difference was observed in efficacy between the MLV1 and MLV2. These results indicate that bat influenza vectored MLV vaccines can be used as a safe live vaccine to prevent swine influenza.

scholarly journals Cluster analysis of the origins of the new influenza A(H1N1) virus

2009 ◽  
Vol 14 (21) ◽  
Author(s):  
A Solovyov ◽  
G Palacios ◽  
T Briese ◽  
W I Lipkin ◽  
R Rabadan
Keyword(s):  
Cluster Analysis ◽  
Influenza A ◽  
H1n1 Virus ◽  
Swine Influenza ◽  
The United States ◽  
Influenza Viruses ◽  
World Health ◽  
Influenza A H1n1 ◽  
The World ◽  
Health Organization

In March and April 2009, a new strain of influenza A(H1N1) virus has been isolated in Mexico and the United States. Since the initial reports more than 10,000 cases have been reported to the World Health Organization, all around the world. Several hundred isolates have already been sequenced and deposited in public databases. We have studied the genetics of the new strain and identified its closest relatives through a cluster analysis approach. We show that the new virus combines genetic information related to different swine influenza viruses. Segments PB2, PB1, PA, HA, NP and NS are related to swine H1N2 and H3N2 influenza viruses isolated in North America. Segments NA and M are related to swine influenza viruses isolated in Eurasia.

scholarly journals Nested RT-PCR method for the detection of European avian-like H1 swine influenza A virus

2016 ◽  
Vol 15 (5) ◽  
pp. 1095-1102
Author(s):  
Yan-di WEI ◽  
Xing-yao PEI ◽  
Yuan ZHANG ◽  
Chen-fang YU ◽  
Hong-lei SUN ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Swine Influenza ◽  
Rt Pcr ◽  
Pcr Method ◽  
Swine Influenza A Virus
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