scholarly journals Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

2012 ◽  
Vol 66 (10) ◽  
pp. 1082-1092 ◽  
Author(s):  
A J Cooper ◽  
◽  
N G Forouhi ◽  
Z Ye ◽  
B Buijsse ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prospective Study ◽  
Vegetable Intake ◽  
Meta Analysis ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable

scholarly journals Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis

BMJ ◽  
2010 ◽  
Vol 341 (aug18 4) ◽  
pp. c4229-c4229 ◽  
Author(s):  
P. Carter ◽  
L. J. Gray ◽  
J. Troughton ◽  
K. Khunti ◽  
M. J. Davies
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Vegetable Intake ◽  
Meta Analysis ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable

scholarly journals A Prospective Study of Fruit and Vegetable Intake and the Risk of Type 2 Diabetes in Women

Diabetes Care ◽  
2004 ◽  
Vol 27 (12) ◽  
pp. 2993-2996 ◽  
Author(s):  
S. Liu ◽  
M. Serdula ◽  
S.-J. Janket ◽  
N. R. Cook ◽  
H. D. Sesso ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prospective Study ◽  
Vegetable Intake ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable ◽  
A Prospective Study

scholarly journals A Prospective Study of the Association Between Quantity and Variety of Fruit and Vegetable Intake and Incident Type 2 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 1293-1300 ◽  
Author(s):  
A. J. Cooper ◽  
S. J. Sharp ◽  
M. A. H. Lentjes ◽  
R. N. Luben ◽  
K.-T. Khaw ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Prospective Study ◽  
Vegetable Intake ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
A Prospective Study

scholarly journals Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries

BMJ ◽  
2020 ◽  
pp. m2194 ◽  
Author(s):  
Ju-Sheng Zheng ◽  
Stephen J Sharp ◽  
Fumiaki Imamura ◽  
Rajiv Chowdhury ◽  
Thomas E Gundersen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin C ◽  
Vegetable Intake ◽  
European Countries ◽  
Fruit And Vegetable Intake ◽  
Plasma Vitamin ◽  
Fruit And Vegetable ◽  
Incident Type ◽  
Incident Type 2 Diabetes

Abstract Objective To investigate the association of plasma vitamin C and carotenoids, as indicators of fruit and vegetable intake, with the risk of type 2 diabetes. Design Prospective case-cohort study. Setting Populations from eight European countries. Participants 9754 participants with incident type 2 diabetes, and a subcohort of 13 662 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort of 340 234 participants: EPIC-InterAct case-cohort study. Main outcome measure Incident type 2 diabetes. Results In a multivariable adjusted model, higher plasma vitamin C was associated with a lower risk of developing type 2 diabetes (hazard ratio per standard deviation 0.82, 95% confidence interval 0.76 to 0.89). A similar inverse association was shown for total carotenoids (hazard ratio per standard deviation 0.75, 0.68 to 0.82). A composite biomarker score (split into five equal groups), comprising vitamin C and individual carotenoids, was inversely associated with type 2 diabetes with hazard ratios 0.77, 0.66, 0.59, and 0.50 for groups 2-5 compared with group 1 (the lowest group). Self-reported median fruit and vegetable intake was 274 g/day, 396 g/day, and 508 g/day for participants in categories defined by groups 1, 3, and 5 of the composite biomarker score, respectively. One standard deviation difference in the composite biomarker score, equivalent to a 66 (95% confidence interval 61 to 71) g/day difference in total fruit and vegetable intake, was associated with a hazard ratio of 0.75 (0.67 to 0.83). This would be equivalent to an absolute risk reduction of 0.95 per 1000 person years of follow up if achieved across an entire population with the characteristics of the eight European countries included in this analysis. Conclusions These findings indicate an inverse association between plasma vitamin C, carotenoids, and their composite biomarker score, and incident type 2 diabetes in different European countries. These biomarkers are objective indicators of fruit and vegetable consumption, and suggest that diets rich in even modestly higher fruit and vegetable consumption could help to prevent development of type 2 diabetes.

scholarly journals Dietary fruit and vegetable intake, gut microbiota, and type 2 diabetes: results from two large human cohort studies

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Zengliang Jiang ◽  
Ting-yu Sun ◽  
Yan He ◽  
Wanglong Gou ◽  
Luo-shi-yuan Zuo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Vegetable Intake ◽  
Sebacic Acid ◽  
Fruit And Vegetable Intake ◽  
Health Study ◽  
Fruit Intake ◽  
Fruit And Vegetable ◽  
Independent Cohort

Abstract Background Little is known about the inter-relationship among fruit and vegetable intake, gut microbiota and metabolites, and type 2 diabetes (T2D) in human prospective cohort study. The aim of the present study was to investigate the prospective association of fruit and vegetable intake with human gut microbiota and to examine the relationship between fruit and vegetable-related gut microbiota and their related metabolites with type 2 diabetes (T2D) risk. Methods This study included 1879 middle-age elderly Chinese adults from Guangzhou Nutrition and Health Study (GNHS). Baseline dietary information was collected using a validated food frequency questionnaire (2008–2013). Fecal samples were collected at follow-up (2015–2019) and analyzed for 16S rRNA sequencing and targeted fecal metabolomics. Blood samples were collected and analyzed for glucose, insulin, and glycated hemoglobin. We used multivariable linear regression and logistic regression models to investigate the prospective associations of fruit and vegetable intake with gut microbiota and the association of the identified gut microbiota (fruit/vegetable-microbiota index) and their related fecal metabolites with T2D risk, respectively. Replications were performed in an independent cohort involving 6626 participants. Results In the GNHS, dietary fruit intake, but not vegetable, was prospectively associated with gut microbiota diversity and composition. The fruit-microbiota index (FMI, created from 31 identified microbial features) was positively associated with fruit intake (p < 0.001) and inversely associated with T2D risk (odds ratio (OR) 0.83, 95%CI 0.71–0.97). The FMI-fruit association (p = 0.003) and the FMI-T2D association (OR 0.90, 95%CI 0.84–0.97) were both successfully replicated in the independent cohort. The FMI-positive associated metabolite sebacic acid was inversely associated with T2D risk (OR 0.67, 95%CI 0.51–0.86). The FMI-negative associated metabolites cholic acid (OR 1.35, 95%CI 1.13–1.62), 3-dehydrocholic acid (OR 1.30, 95%CI 1.09–1.54), oleylcarnitine (OR 1.77, 95%CI 1.45–2.20), linoleylcarnitine (OR 1.66, 95%CI 1.37–2.05), palmitoylcarnitine (OR 1.62, 95%CI 1.33–2.02), and 2-hydroglutaric acid (OR 1.47, 95%CI 1.25–1.72) were positively associated with T2D risk. Conclusions Higher fruit intake-associated gut microbiota and metabolic alteration were associated with a lower risk of T2D, supporting the public dietary recommendation of adopting high fruit intake for the T2D prevention.

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