scholarly journals Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women

2011 ◽  
Vol 66 (5) ◽  
pp. 606-612 ◽  
Author(s):  
P S Hinton ◽  
R S Rector ◽  
M A Linden ◽  
S O Warner ◽  
K C Dellsperger ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Bone Turnover ◽  
Aerobic Exercise ◽  
Bone Mineral ◽  
Weight Regain ◽  
Obese Women ◽  
Mineral Density ◽  
Partial Weight

scholarly journals Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity

2016 ◽  
Vol 28 (3) ◽  
Author(s):  
Claudia Harper ◽  
Andrea L. Pattinson ◽  
Hamish A. Fernando ◽  
Jessica Zibellini ◽  
Radhika V. Seimon ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bariatric Surgery ◽  
Weight Loss ◽  
Bone Turnover ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Dietary Restriction ◽  
Mineral Density ◽  
Pre Treatment ◽  
Obesity Treatments

AbstractBackground:New evidence suggests that obesity is deleterious for bone health, and obesity treatments could potentially exacerbate this.Materials and methods:This narrative review, largely based on recent systematic reviews and meta-analyses, synthesizes the effects on bone of bariatric surgery, weight loss pharmaceuticals and dietary restriction.Results and conclusions:All three obesity treatments result in statistically significant reductions in hip bone mineral density (BMD) and increases in bone turnover relative to pre-treatment values, with the reductions in hip BMD being strongest for bariatric surgery, notably Roux-en Y gastric bypass (RYGB, 8%–11% of pre-surgical values) and weakest for dietary restriction (1%–1.5% of pre-treatment values). Weight loss pharmaceuticals (orlistat or the glucagon-like peptide-1 receptor agonist, liraglutide) induced no greater changes from pre-treatment values than control, despite greater weight loss. There is suggestive evidence that liraglutide may increase bone mineral content (BMC) – but not BMD – and reduce fracture risk, but more research is required to clarify this. All three obesity treatments have variable effects on spine BMD, probably due to greater measurement error at this site in obesity, suggesting that future research in this field could focus on hip rather than spine BMD. Various mechanisms have been proposed for BMD loss with obesity treatments, notably reduced nutritional intake/absorption and insufficient exercise, and these are potential avenues for protection against bone loss. However, a pressing outstanding question is whether this BMD reduction contributes to increased fracture risk, as has been observed after RYGB, and whether any such increase in fracture risk outweighs the risks of staying obese (unlikely).

scholarly journals Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults

2017 ◽  
Vol 72 (11) ◽  
pp. 1582-1585 ◽  
Author(s):  
Kristen M Beavers ◽  
Daniel P Beavers ◽  
Sarah B Martin ◽  
Anthony P Marsh ◽  
Mary F Lyles ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Weight Loss ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Bone Mineral ◽  
Aerobic Exercise Training ◽  
Mineral Density

Bone turnover markers and bone mineral density after 12-month weight loss therapy in obese children

2015 ◽  
Author(s):  
Joanna Gajewska ◽  
Witold Klemarczyk ◽  
Jadwiga Ambroszkiewicz ◽  
Magdalena Chelchowska ◽  
Halina Weker
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Obese Children ◽  
Mineral Density ◽  
Turnover Markers ◽  
Weight Loss Therapy

Aerobic exercise maintains regional bone mineral density during weight loss in postmenopausal women

1998 ◽  
Vol 84 (4) ◽  
pp. 1305-1310 ◽  
Author(s):  
Alice S. Ryan ◽  
Barbara J. Nicklas ◽  
Karen E. Dennis
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Aerobic Exercise ◽  
Postmenopausal Women ◽  
Older Women ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Mineral Density ◽  
Regional Bone Mineral Density ◽  
Total Body

This study examines the effects of weight loss by caloric restriction (WL) and aerobic exercise plus weight loss (AEx+WL) on total and regional bone mineral density (BMD) in older women. Healthy, postmenopausal women [age 63 ± 1 (SE) yr] not on hormone-replacement therapy underwent 6 mo of WL ( n = 15) consisting of dietary counseling one time per week with a caloric deficit (250–350 kcal/day) or AEx+WL ( n = 15) consisting of treadmill exercise three times per week in addition to the weight loss. Maximal aerobic capacity increased only in the AEx+WL group ( P < 0.001). Body weight, percent fat, and fat mass decreased similarly in both groups ( P < 0.005), with no changes in fat-free mass. Total body BMD (by dual-energy X-ray absorptiometry) decreased in both groups ( P < 0.05). Femoral neck, Ward’s triangle, and greater trochanter BMD decreased in the WL group ( P ≤ 0.05) but were not significantly different after AEx+WL. L2–L4BMD did not significantly change in either group. Thus WL and AEx+WL both result in losses of total body BMD; however, AEx+WL appears to prevent the loss in regional BMD seen with WL alone in healthy, older women. This suggests that the addition of exercise to weight-loss programs may reduce the risk for bone loss.

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