scholarly journals Changes in bone mineral density and bone turnover markers in obese women after short-term weight loss therapy during a 5-year follow-up

2010 ◽  
Vol 120 (7-8) ◽  
pp. 248-254 ◽  
Author(s):  
Michał Holecki ◽  
Barbara Zahorska‑Markiewicz ◽  
Jerzy Chudek ◽  
Andrzej Więcek
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Obese Women ◽  
Mineral Density ◽  
Short Term ◽  
Turnover Markers ◽  
Weight Loss Therapy

Bone turnover markers and bone mineral density after 12-month weight loss therapy in obese children

2015 ◽  
Author(s):  
Joanna Gajewska ◽  
Witold Klemarczyk ◽  
Jadwiga Ambroszkiewicz ◽  
Magdalena Chelchowska ◽  
Halina Weker
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Obese Children ◽  
Mineral Density ◽  
Turnover Markers ◽  
Weight Loss Therapy

Bone mineral density and bone turnover markers in patients with thyroid cancer and L-T4 suppressive therapy after 25 years of follow-up

2014 ◽  
Author(s):  
Mingo Dominguez Maria Luisa de ◽  
Sonsoles Guadalix Iglesias ◽  
Maria Begona Lopez Alvarez ◽  
Guillermo Martinez Diaz-Guerra ◽  
Federico Hawkins Carranza
Keyword(s):  
Bone Mineral Density ◽  
Thyroid Cancer ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Suppressive Therapy ◽  
Mineral Density ◽  
Turnover Markers

Short-Term Effects of TNF Inhibitors on Bone Turnover Markers and Bone Mineral Density in Rheumatoid Arthritis

2016 ◽  
Vol 98 (6) ◽  
pp. 580-585 ◽  
Author(s):  
Giovanni Orsolini ◽  
Giovanni Adami ◽  
Silvano Adami ◽  
Ombretta Viapiana ◽  
Luca Idolazzi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Tnf Inhibitors ◽  
Mineral Density ◽  
Short Term ◽  
Turnover Markers ◽  
Short Term Effects

scholarly journals Observational Study to Evaluate the Effect of Epidural Steroid Injection on Bone Mineral Density and Bone Turnover Markers

2020 ◽  
Vol 5;23 (9;5) ◽  
pp. E517-E524
Author(s):  
Paras Gupta
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Steroid Injection ◽  
Epidural Steroid Injection ◽  
Mineral Density ◽  
Turnover Markers ◽  
Epidural Steroid

Background: Epidural steroid injection (ESI) is widely used to manage low back pain. ESIs are commonly performed to treat pain accompanying intervertebral disc prolapse, spinal stenosis, facet joint pathologies, and other degenerative spinal pathologies. Corticosteroids for musculoskeletal conditions, regardless of the route of administration, can reduce bone mineral density (BMD) and increase the risk of fracture. With paraspinal administration of steroids, the severity of risk is enhanced as the steroid is being deposited in close proximity to bone. BMD and molecular markers of bone metabolism are the standard methods to assess the effect of any insult on bone strength and bone metabolism. Carboxy terminal crosslinked telopeptides of type 1 collagen (sCTX) and serum Procollagen Type I N-terminal propeptide (P1NP) are the reference markers of bone resorption and formation, respectively. Objective: We conducted this study to determine the effect of ESI on BMD and bone turnover markers. Study Design: This was a prospective observational cohort study, involving a cohort of 264 patients between the ages of 40 to 60 years who were advised to undergo ESI at L3-4 or L4-5 by their pain physician. Setting: Research was conducted at a tertiary care teaching hospital pain clinic in collaboration with the department of orthopaedics and radiodiagnosis. Methods: Serum CTX-1, P1NP, and pre-ESI BMD of the spine, femur neck, and dual femur were evaluated at baseline; these same parameters were serially evaluated post ESI on follow-ups at 1, 3, and 6 months. Additional follow-up at 10 days post ESI was called for evaluation of bone turnover markers (BTMs). A paired t test was used to analyze changes in BMD and BTMs vs baseline within the group. Cumulative incidence and relative risk of moderate to markedly low BMD were calculated using standard formulas. Any fractures sustained during follow-ups were also evaluated thoroughly and quantified separately. A P value less than .05 was considered statistically significant. Results: The proportion of pre-ESI moderately to markedly low BMD was 10.22% in the study population. There was a statistically significant increase in serum CTX 10 days post ESI which persisted at the one-month and 3-month follow-ups. There was no significant change in serum P1NP level post ESI after 7 days and at the one-month follow-up. The mean value of serum P1NP was, however, significantly higher at the 3-month follow-up. Statistical comparison of the mean BMD value at the spine and femur neck revealed statistically significant decline 3 months post ESI. There was no significant impact of ESI on the total femur BMD. The cumulative incidence of moderately low to markedly low BMD over a period of 6 months in the study population was 45 out of 223, i.e., 20.17%. Limitations: The study’s primary limitations included its high dropout rate, a larger reference range for BTMs, making them a less specific tool for comparison, and the absence of a control group. ESI has a negative impact on the BMD of the hip and spine. Reduced BMD should be considered as a potential side effect of ESI. Key words: Bone mineral density, bone turnover markers, epidural steroid injection, low back ache, osteoporosis Pain Physician 202

scholarly journals Effects of Epidural Steroid Injections on Bone Mineral Density and Bone Turnover Markers in Patients Taking Anti-Osteoporotic Medications

2018 ◽  
Vol 1 (21;1) ◽  
pp. E435-E447
Author(s):  
Jae Hyup Lee
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Turnover Markers ◽  
Group 2 ◽  
Epidural Steroid ◽  
Group 1

Background: Glucocorticoids adversely affect bone mineral density (BMD) and increase the risk of fracture. Yet, the cause-and-effect relationship between epidural steroid injection (ESI) and BMD has not been thoroughly investigated, and available results are inconsistent. This is probably a consequence of differences in the dose of steroids and follow-up duration. Objective: This study aimed to evaluate changes in BMD and the risk of fracture according to duration of the follow-up and amount of steroids used for ESI. Setting: Department of Orthopedic Surgery at Seoul Metropolitan Government Seoul National University (SMG-SNU) Boramae Medical Center, Korea. Methods: We retrospectively reviewed the medical records of postmenopausal patients who underwent dual-energy x-ray absorptiometry (DEXA) at least 3 times in 5 years. Patients were divided into 2 groups. Group 1 consisted of 73 patients who received ESI, whereas Group 2 consisted of 294 patients who did not receive ESI. All patients took anti-osteoporotic medications. BMD measurements were performed in 4 different regions, and levels of bone turnover markers (BTMs) were measured. In Group 1, BMD and BTMs levels were measured before the last ESI and 1 and 2 years after. A sub-analysis was conducted in Group 1 to compare BMD values in sub-groups with different doses of steroids. Results: In Group 1, the absolute values of BMD of the spine were decreased at the 1-year follow-up, but by the 2-year follow-up they recovered and approached the values in Group 2. In Group 2, BMD increased both at the 1- and 2-year follow-ups. There was an increase in occurrence of osteoporosis during the first year after ESI, but the prevalence of osteoporosis declined remarkably during the second year. The levels of BTMs increased at the 1-year followup and decreased at the 2-year follow-up in Group 1. Higher cumulative doses of steroids induced greater decreases in BMD. However, the changes in spine BMD in the sub-analysis were insignificant. Limitations: This was a retrospective study. Additionally, administration of anti-osteoporotic medication might have prevented accurate evaluation of the effects of ESI. Conclusions: ESI adversely affects BMD in postmenopausal women, especially that of the spine, and the adverse effects increase with the dose of steroids. Gradual reduction of the effect of steroids one year after the cessation of ESI resulted in recovery of BMD to a level similar to that in the control group. Key words: Epidural steroid injection, bone mineral density, osteoporosis, postmenopausal women, glucocorticoids, bone turnover markers, osteoporotic fracture

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