scholarly journals Vitamin D and type 2 diabetes: a systematic review

2011 ◽  
Vol 65 (9) ◽  
pp. 1005-1015 ◽  
Author(s):  
J Mitri ◽  
M D Muraru ◽  
A G Pittas
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Vitamin D

Vitamin D ratio and glycaemic control in individuals with type 2 diabetes mellitus: A systematic review

2017 ◽  
Vol 34 (3) ◽  
pp. e2969 ◽  
Author(s):  
Ramara Kadija Fonseca Santos ◽  
Paula Nascimento Brandão-Lima ◽  
Raissa Maria Dumas Delatore Tete ◽  
Analícia Rocha Santos Freire ◽  
Liliane Viana Pires
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Glycaemic Control

scholarly journals Evaluating the Use of Vitamin D Supplementation to Improve Glycaemic Outcome in Type 2 Diabetes Mellitus Patients: A Systematic Review of Evidence

2017 ◽  
Vol 07 (04) ◽  
pp. 223-240
Author(s):  
Mzwandile A. Mabhala ◽  
Adetoyosi Babanumi ◽  
Anthony Olagunju ◽  
Eloho Akata ◽  
Asmait Yohannes
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Supplementation

scholarly journals Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies

2012 ◽  
Vol 72 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Hassan Khan ◽  
Setor Kunutsor ◽  
Oscar H. Franco ◽  
Rajiv Chowdhury
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Prospective Studies ◽  
Metabolic Diseases ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Vitamin D Status ◽  
Metabolic Outcomes

Vitamin D status may influence the risk of developing metabolic diseases such as Type 2 diabetes (T2D), metabolic syndrome (MetS) and insulin resistance (IR). Several studies have assessed vitamin D in relationship with metabolic outcomes; however, results remain inconsistent. A systematic review and meta-analysis using multiple databases (MEDLINE, Web of Science and EMBASE), was performed up to 10 August 2012. Prospective studies reporting association of circulating or dietary vitamin D with incident T2D, MetS and IR outcomes were included. Relative risks (RR) were pooled using random effects and subgroup analysis by pertinent study-level characteristics was performed. A total of seventeen articles based on eighteen unique prospective studies, and comprising 210 107 participants with 15 899 metabolic events, collected during a median follow up of 10 years (range 3–22 years), were included. RR for individuals in top v. bottom thirds of baseline vitamin D were 0·81 (95% CI 0·71, 0·92); 0·86 (95% CI 0·80, 0·92); and 0·84 (95% CI 0·64, 1·12) for T2D, MetS and IR outcomes, respectively. Moderate heterogeneity was found between fourteen studies (I2 = 67%, P < 0·001) reporting on T2D. Findings were generally consistent across various study-level characteristics. In conclusion, vitamin D status at baseline in apparently healthy adults is inversely associated with future risks of T2D and MetS. Interventions aimed at maintaining adequate levels of vitamin D in addition to preventing deficiency may be a useful preventive measure for metabolic diseases. However, reliable evidence from carefully designed intervention studies, particularly those based on healthy populations, is needed to confirm observational findings.

scholarly journals Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 8-15 ◽  
Author(s):  
Paola Lucato ◽  
Marco Solmi ◽  
Stefania Maggi ◽  
Anna Bertocco ◽  
Giulia Bano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Vitamin D ◽  
Meta Analysis ◽  
Vitamin D Levels

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

2017 ◽  
Vol 176 (1) ◽  
pp. R1-R14 ◽  
Author(s):  
Yvonne H M Krul-Poel ◽  
Marieke M ter Wee ◽  
Paul Lips ◽  
Suat Simsek
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Glycaemic Control ◽  
Fasting Glucose ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Current Evidence ◽  
Cochrane Library

Objective Epidemiologic studies suggest that vitamin D status plays a role in glycaemic control in patients with type 2 diabetes. However, intervention studies yielded inconsistent results. The aim of this study is to systematically review the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. Methods Systematic review and meta-analysis. We searched Medline, Embase and the Cochrane Library for RCTs examining the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. A random-effects model meta-analysis was performed to obtain a summarized outcome of vitamin D supplementation on HbA1c, fasting glucose and homeostasis model assessment – insulin resistance (HOMA-IR). Results Twenty-three RCTs were included in this systematic review representing a total of 1797 patients with type 2 diabetes. Mean (± s.d.) change in serum 25-hydroxyvitamin D varied from 1.8 ± 10.2 nmol/L to 80.1 ± 54.0 nmol/L. Nineteen studies included HbA1c as outcome variable. Combining these studies no significant effect in change of HbA1c was seen after vitamin D intervention compared with placebo. A significant effect of vitamin D supplementation was seen on fasting glucose in a subgroup of studies (n = 4) with a mean baseline HbA1c ≥ 8% (64 mmol/mol) (standardized difference in means: 0.36; 95% CI: 0.12–0.61, P = 0.003). Conclusions Current evidence of RCTs does not support short-term vitamin D supplementation in a heterogeneous population with type 2 diabetes. However, in patients with poorly controlled diabetes, a favourable effect of vitamin D is seen on fasting glucose.

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