scholarly journals Low vitamin D levels increase the risk of type 2 diabetes in older adults: A systematic review and meta-analysis

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 8-15 ◽  
Author(s):  
Paola Lucato ◽  
Marco Solmi ◽  
Stefania Maggi ◽  
Anna Bertocco ◽  
Giulia Bano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Vitamin D ◽  
Meta Analysis ◽  
Vitamin D Levels

scholarly journals Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies

2012 ◽  
Vol 72 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Hassan Khan ◽  
Setor Kunutsor ◽  
Oscar H. Franco ◽  
Rajiv Chowdhury
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Prospective Studies ◽  
Metabolic Diseases ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Vitamin D Status ◽  
Metabolic Outcomes

Vitamin D status may influence the risk of developing metabolic diseases such as Type 2 diabetes (T2D), metabolic syndrome (MetS) and insulin resistance (IR). Several studies have assessed vitamin D in relationship with metabolic outcomes; however, results remain inconsistent. A systematic review and meta-analysis using multiple databases (MEDLINE, Web of Science and EMBASE), was performed up to 10 August 2012. Prospective studies reporting association of circulating or dietary vitamin D with incident T2D, MetS and IR outcomes were included. Relative risks (RR) were pooled using random effects and subgroup analysis by pertinent study-level characteristics was performed. A total of seventeen articles based on eighteen unique prospective studies, and comprising 210 107 participants with 15 899 metabolic events, collected during a median follow up of 10 years (range 3–22 years), were included. RR for individuals in top v. bottom thirds of baseline vitamin D were 0·81 (95% CI 0·71, 0·92); 0·86 (95% CI 0·80, 0·92); and 0·84 (95% CI 0·64, 1·12) for T2D, MetS and IR outcomes, respectively. Moderate heterogeneity was found between fourteen studies (I2 = 67%, P < 0·001) reporting on T2D. Findings were generally consistent across various study-level characteristics. In conclusion, vitamin D status at baseline in apparently healthy adults is inversely associated with future risks of T2D and MetS. Interventions aimed at maintaining adequate levels of vitamin D in addition to preventing deficiency may be a useful preventive measure for metabolic diseases. However, reliable evidence from carefully designed intervention studies, particularly those based on healthy populations, is needed to confirm observational findings.

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

2017 ◽  
Vol 176 (1) ◽  
pp. R1-R14 ◽  
Author(s):  
Yvonne H M Krul-Poel ◽  
Marieke M ter Wee ◽  
Paul Lips ◽  
Suat Simsek
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Glycaemic Control ◽  
Fasting Glucose ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Current Evidence ◽  
Cochrane Library

Objective Epidemiologic studies suggest that vitamin D status plays a role in glycaemic control in patients with type 2 diabetes. However, intervention studies yielded inconsistent results. The aim of this study is to systematically review the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. Methods Systematic review and meta-analysis. We searched Medline, Embase and the Cochrane Library for RCTs examining the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. A random-effects model meta-analysis was performed to obtain a summarized outcome of vitamin D supplementation on HbA1c, fasting glucose and homeostasis model assessment – insulin resistance (HOMA-IR). Results Twenty-three RCTs were included in this systematic review representing a total of 1797 patients with type 2 diabetes. Mean (± s.d.) change in serum 25-hydroxyvitamin D varied from 1.8 ± 10.2 nmol/L to 80.1 ± 54.0 nmol/L. Nineteen studies included HbA1c as outcome variable. Combining these studies no significant effect in change of HbA1c was seen after vitamin D intervention compared with placebo. A significant effect of vitamin D supplementation was seen on fasting glucose in a subgroup of studies (n = 4) with a mean baseline HbA1c ≥ 8% (64 mmol/mol) (standardized difference in means: 0.36; 95% CI: 0.12–0.61, P = 0.003). Conclusions Current evidence of RCTs does not support short-term vitamin D supplementation in a heterogeneous population with type 2 diabetes. However, in patients with poorly controlled diabetes, a favourable effect of vitamin D is seen on fasting glucose.

scholarly journals Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies

Diabetes Care ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 1422-1428 ◽  
Author(s):  
Y. Song ◽  
L. Wang ◽  
A. G. Pittas ◽  
L. C. Del Gobbo ◽  
C. Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Incident Type ◽  
Vitamin D Levels ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxy Vitamin D

scholarly journals Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2286 ◽  
Author(s):  
Diego Marcos-Pérez ◽  
María Sánchez-Flores ◽  
Stefania Proietti ◽  
Stefano Bonassi ◽  
Solange Costa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Vitamin D ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Sensitivity Analyses ◽  
Intermediate Step ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Meta Analyses

Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and thirteen studies were included in the meta-analyses. Quantitative analyses showed significant differences in the comparisons of frail (standardized mean difference (SMD)—1.31, 95% confidence interval (CI) (−2.47, −0.15), p = 0.0271) and pre-frail (SMD—0.79, 95% CI (−1.58, −0.003), p = 0.0491) subjects vs. non-frail subjects. Sensitivity analyses reduced heterogeneity, resulting in a smaller but still highly significant between-groups difference. Results obtained indicate that lower 25(OH)D levels are significantly associated with increasing frailty severity. Future challenges include interventional studies testing the possible benefits of vitamin D supplementation in older adults to prevent/palliate frailty and its associated outcomes.

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