scholarly journals Influence of GABA-B Agonist Baclofen on Capsaicin-Induced Excitation of Secondary Peristalsis in Humans

2017 ◽  
Vol 8 (10) ◽  
pp. e120 ◽  
Author(s):  
Wei-Yi Lei ◽  
Jui-Sheng Hung ◽  
Tso-Tsai Liu ◽  
Chih-Hsun Yi ◽  
Chien-Lin Chen
Keyword(s):  
Secondary Peristalsis

Tu1426 Differences in the Control of Distension-Induced Secondary Peristalsis in Human Esophagus: the Role of 5-HT4 Receptor Versus TRPV1 Receptor

2015 ◽  
Vol 148 (4) ◽  
pp. S-887
Author(s):  
Chien-Lin Chen ◽  
Tso-Tsai Liu ◽  
Chih-Hsun Yi ◽  
Wei-Yi Lei ◽  
Jui-Sheng Hung
Keyword(s):  
Trpv1 Receptor ◽  
Human Esophagus ◽  
Secondary Peristalsis

Comparison of primary and secondary esophageal peristalsis in humans: effect of atropine

1991 ◽  
Vol 260 (1) ◽  
pp. G52-G57 ◽  
Author(s):  
W. G. Paterson ◽  
T. T. Hynna-Liepert ◽  
M. Selucky
Keyword(s):  
Neural Pathways ◽  
Esophageal Peristalsis ◽  
Healthy Male ◽  
Double Blind ◽  
Primary Peristalsis ◽  
Lower Amplitude ◽  
Catheter System ◽  
The Subject ◽  
Esophageal Sphincter ◽  
Secondary Peristalsis

To determine whether physiological differences exist between primary (swallow-induced) and secondary (distension-induced) peristalsis in humans, 10 healthy male volunteers underwent esophageal manometry on 2 consecutive days using a perfused intraluminal catheter system that incorporated a latex balloon. Initially the catheter was positioned so that the balloon was centered 16 cm above the lower esophageal sphincter (LES), and intraluminal pressures were recorded 21, 11, 6, and 1 cm above the LES. After a series of wet swallows, dry swallows, and balloon distensions, the catheter was repositioned so that the balloon was 6 cm above the LES and pressures were recorded 1 and 11 cm above the LES. A series of balloon distensions were repeated in this position, and the subject was then given either atropine (10 micrograms/kg iv) or placebo in a double-blind randomized fashion (on consecutive days). The protocol was then repeated in reverse order. Distension-induced responses aboral to the balloon with the balloon located 16 cm above the LES were 1) of lower amplitude, 2) more often nonperistaltic, and 3) less atropine sensitive than swallow-induced contractions at comparable sites. With the balloon located distally (6 cm above LES) contractions induced at the 11-cm site (i.e., orad to the balloon) were much more atropine sensitive than contractions induced at the same site when the balloon was located proximally (i.e., 16 cm above LES). These data suggest that, contrary to previous reports, secondary peristalsis differs significantly from primary peristalsis. Furthermore, atropine differentially effects these two types of peristalsis, suggesting that the neural pathways involved are dissimilar.

scholarly journals Effects of esophageal acid infusion vs mosapride on distension‐induced secondary peristalsis in humans

2019 ◽  
Vol 35 (5) ◽  
pp. 310-314
Author(s):  
Wei‐Yi Lei ◽  
Jui‐Sheng Hung ◽  
Chih‐Hsun Yi ◽  
Tso‐Tsai Liu ◽  
Ming‐Wun Wong ◽  
...  
Keyword(s):  
Acid Infusion ◽  
Secondary Peristalsis

Tu1600 - Gaba-B Agonist Baclofen Inhibits Acid-Induced Excitation of Secondary Peristalsis but not Heartburn Sensation

2018 ◽  
Vol 154 (6) ◽  
pp. S-963
Author(s):  
Chien-Lin Chen ◽  
Chih-Hsun Yi ◽  
Wei-Yi Lei ◽  
Jui-Sheng Hung ◽  
Tso-Tsai Liu ◽  
...  
Keyword(s):  
Secondary Peristalsis

Tu1412 IMPACT OF INEFFECTIVE ESOPHAGEAL MOTILITY ON SECONDARY PERISTALSIS IN GERD: STUDIES WITH HIGH RESOLUTION MANOMETRY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1095-S-1096
Author(s):  
Wei-Yi Lei ◽  
Jen-Hung Wang ◽  
Ming-Wun Wong ◽  
Chih-Hsun Yi ◽  
Tso-Tsai Liu ◽  
...  
Keyword(s):  
High Resolution ◽  
Esophageal Motility ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility ◽  
Secondary Peristalsis

Altered oesophageal mechanosensitivity of secondary peristalsis as a pathophysiological marker in patients with globus sensation

2017 ◽  
Vol 43 (1) ◽  
pp. 306-311 ◽  
Author(s):  
W-Y. Lei ◽  
J-S. Hung ◽  
T-T. Liu ◽  
C-H. Yi ◽  
C-L. Chen
Keyword(s):  
Globus Sensation ◽  
Secondary Peristalsis

Absence of a deglutitive inhibition equivalent with secondary peristalsis

2005 ◽  
Vol 288 (4) ◽  
pp. G671-G676 ◽  
Author(s):  
John E. Pandolfino ◽  
Guoxiang Shi ◽  
Qing Zhang ◽  
Peter J. Kahrilas
Keyword(s):  
Smooth Muscle ◽  
Lower Esophageal Sphincter ◽  
Intrinsic Property ◽  
Air Injection ◽  
Success Rates ◽  
Primary Peristalsis ◽  
No Inhibition ◽  
Lower Esophageal Sphincter Relaxation ◽  
Esophageal Sphincter ◽  
Secondary Peristalsis

This study aimed to determine the interactions between closely paired swallow-induced primary peristalsis (PP) and air injection-induced secondary peristalsis (SP). Ten subjects (7 men, 18–42 yr) were studied using a catheter, including two sleeves (upper and lower esophageal sphincters), a midesophageal infusion port, and seven esophageal and two pharyngeal recording sites. Ten iterations of PP and SP were induced by 5-ml water swallows and 20-ml intraesophageal air injections, respectively. Thereafter, the interactions between PP and SP, separated by 1- to 12-s intervals, were studied in all four possible sequences: paired swallows, swallow preceded by air injection, air injection preceded by swallow, and paired air injections. Tracings were analyzed for lower esophageal sphincter relaxation, presence and integrity of peristalsis, and event interaction. Eight subjects with success rates of both ≥90% PP and ≥80% SP were analyzed (PP 97 ± 2%, SP 90 ± 3%). During paired PP interactions and SP followed by PP, the first sequence was inhibited by the second with intervals < 4–6 s. However, no inhibition of the first peristaltic sequence was found in either PP followed by SP trials or SP followed by air injection. In contrast to swallowing or proximal esophageal distention, air injection into the lumen of the midesophagus does not inhibit an ongoing peristaltic event. Being that the elicitation of SP in the smooth muscle esophagus is intramurally mediated, this suggests that deglutitive inhibition is a centrally mediated phenomenon rather than an intrinsic property of peristalsis.

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