scholarly journals Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps

2017 ◽  
Vol 8 (4) ◽  
pp. e88 ◽  
Author(s):  
Brooke R Druliner ◽  
Xiaoyang Ruan ◽  
Ruth Johnson ◽  
Diane Grill ◽  
Daniel OʼBrien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Time Lapse ◽  
Malignant Potential ◽  
Telomere Dynamics

scholarly journals Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps

2016 ◽  
Vol 7 (9) ◽  
pp. e188 ◽  
Author(s):  
Brooke R Druliner ◽  
Xiaoyang Ruan ◽  
Ruth Johnson ◽  
Diane Grill ◽  
Daniel OʼBrien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Time Lapse ◽  
Malignant Potential ◽  
Telomere Dynamics

scholarly journals Artificial intelligence assisted standard white light endoscopy accurately characters early colorectal cancer: a multicenter diagnostic study

2020 ◽  
Author(s):  
Sijun Meng ◽  
Yueping Zheng ◽  
Ruizhang Su ◽  
Wangyue Wang ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Colorectal Cancer ◽  
Malignant Potential ◽  
Early Colorectal Cancer ◽  
Diagnostic Study ◽  
Internal Validation ◽  
White Light Endoscopy ◽  
Incidence And Mortality ◽  
Validation Set ◽  
Screening And Prevention

ABSTRACTColorectal cancer (CRC) is the third in incidence and mortality1 of cancer. Screening with colonoscopy has been shown to reduce mortality by 40-60%2. Challenge for screening indistinguishable precancerous and noninvasive lesion using conventional colonoscopy was still existing3. We propose to establish a propagable artificial intelligence assisted high malignant potential early CRC characterization system (ECRC-CAD). 4,390 endoscopic images of early CRC were used to establish the model. The diagnostic accuracy of high malignant potential early CRC was 0.963 (95% CI, 0.941-0.978) in the internal validation set and 0.835 (95% CI, 0.805-0.862) in external datasets. It achieved better performance than the expert endoscopists. Spreading of ECRC-CAD to regions with different medical levels can assist in CRC screening and prevention.

scholarly journals Claudin-3 Overexpression Increases the Malignant Potential of Colorectal Cancer Cells: Roles of ERK1/2 and PI3K-Akt as Modulators of EGFR signaling

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74994 ◽  
Author(s):  
Waldemir F. de Souza ◽  
Natalia Fortunato-Miranda ◽  
Bruno K. Robbs ◽  
Wallace M. de Araujo ◽  
Julio C. de-Freitas-Junior ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Malignant Potential ◽  
Egfr Signaling ◽  
Colorectal Cancer Cells

scholarly journals Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer

2020 ◽  
Author(s):  
Xiaobin Zheng ◽  
Jinhee Hur ◽  
Long H Nguyen ◽  
Jie Liu ◽  
Mingyang Song ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Diet Quality ◽  
Early Onset ◽  
Strong Support ◽  
Healthy Eating Index ◽  
Malignant Potential ◽  
Poor Diet ◽  
Increased Risk

Abstract Background The role of poor diet quality in the rising incidence of colorectal cancer (CRC) diagnosed under age 50 has not been explored. Based on molecular features of early-onset CRC, early-onset adenomas are emerging surrogate endpoints. Methods In a prospective cohort study (Nurses’ Health Study II), we evaluated two empirical dietary patterns (Western and prudent) and three recommendation-based indexes (Dietary Approaches to Stop Hypertension [DASH], Alternative Mediterranean Diet [AMED], and Alternative Healthy Eating Index [AHEI]-2010) with risk of early-onset adenoma overall and by malignant potential (high-risk: ≥1 cm, tubulovillous/villous histology, high-grade dysplasia, or ≥ 3 adenomas), among 29474 women with ≥1 lower endoscopy before age 50 (1991-2011). Multivariable logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results We documented 1157 early-onset adenomas with 375 of high-risk. Western diet was positively, whereas prudent diet, DASH, AMED, and AHEI-2010 were inversely associated with risk of early-onset adenoma. The associations were largely confined to high-risk adenomas (OR [95% CI] for the highest versus lowest quintile: Western = 1.67 [1.18 to 2.37]; prudent = 0.69 [0.48 to 0.98]; DASH = 0.65 [0.45 to 0.93]; AMED = 0.55 [0.38 to 0.79]; AHEI-2010 = 0.71 [0.51 to 1.01]; all P  trend≤.03), driven by those identified in the distal colon and rectum (all P  trend≤.04 except AMED: Ptrend=.14). Conclusion Poor diet quality was associated with an increased risk of early-onset distal and rectal adenomas of high malignant potential. These findings provide preliminary but strong support to the role of diet in early-onset CRC.

scholarly journals Primary Adenocarcinoma at Colostomy Site: Report of a Clinical Case

2021 ◽  
Author(s):  
Carlos Sardiñas ◽  
Bagher Nouri ◽  
Andrea Cifuentes ◽  
María Eugenia Oropeza
Keyword(s):  
Colorectal Cancer ◽  
United States ◽  
Postoperative Period ◽  
Clinical Case ◽  
The United States ◽  
Malignant Potential ◽  
Primary Adenocarcinoma ◽  
Hyperplastic Polyps ◽  
Colostomy Site ◽  
Late Postoperative Period

AbstractColorectal cancer (CRC) is the fourth most frequently diagnosed cancer in the United States and it is found in 17% of patients thought to have complicated diverticular disease. However, primary adenocarcinoma rarely occur in the colostomy site and the risk of developing malignancy is similar to that of any other colonic segment. Polyps found in CRC screenings can be divided into the following types: hyperplastic polyps, polyps with no malignant potential, adenomatous polyps, polyps with malignant potential, and malignancies. Local complications of the colostomy can appear in the immediate, early, or late postoperative period, with an incidence ranging from 15 to 30%; neoplasia is even less common.

scholarly journals Malignant potential of lung metastasis from colorectal cancer.

1998 ◽  
Vol 12 (2) ◽  
pp. 107-114
Author(s):  
Hiroshi Otsuka ◽  
Sadao Funai ◽  
Yukihiko Hashimoto ◽  
Kosaku Nishi ◽  
Ken Hirohata ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lung Metastasis ◽  
Malignant Potential

scholarly journals Polyp Genetics

2016 ◽  
Vol 29 (04) ◽  
pp. 289-295
Author(s):  
Coen Klos ◽  
Sekhar Dharmarajan
Keyword(s):  
Colorectal Cancer ◽  
Invasive Carcinoma ◽  
Colorectal Polyps ◽  
Malignant Potential ◽  
Targeted Therapeutics ◽  
Genetic Pathways ◽  
Molecular Events ◽  
Normal Colonic Epithelium ◽  
Colon And Rectum ◽  
Genetic Events

AbstractThe genetic events involved in the transformation of normal colonic epithelium to neoplastic polyps to invasive carcinoma, as initially proposed by Fearon and Vogelstein, form the foundation of our understanding of colorectal cancer. The identification of the polyp as the precursor lesion to colorectal cancer is the basis of many of our current practices for screening, surveillance, and prevention. The last three decades have seen a veritable explosion in our understanding of the molecular events involved in the pathogenesis of colorectal cancer. It is now clear that there are multiple genetic pathways in the polyp to carcinoma sequence. Some polyps previously thought to be nonneoplastic have now been shown to have malignant potential. Finally, increased understanding of the sequence of genetic events has led to the development of targeted therapeutics. The clinical translation of these scientific advances has made a significant impact on the management of patients with colorectal cancer. Accordingly, it is imperative that all clinicians caring for these patients have an understanding of the genetics of colorectal polyps and cancer. In this article, we review the etiology and genetic pathways to carcinoma associated with a range of polyps of the colon and rectum.

scholarly journals Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Åsa Håkansson ◽  
Camilla Bränning ◽  
Göran Molin ◽  
Diya Adawi ◽  
Marie-Louise Hagslätt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colonic Mucosa ◽  
Clinical Situation ◽  
Viable Count ◽  
Malignant Potential ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Colonic Tumour ◽  
Altered Liver ◽  
Colonic Content

Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count ofEnterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.

scholarly journals UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity

2014 ◽  
Vol 206 (5) ◽  
pp. 619-633 ◽  
Author(s):  
Zheng Wang ◽  
Lara M. Linden ◽  
Kaleb M. Naegeli ◽  
Joshua W. Ziel ◽  
Qiuyi Chi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Membrane ◽  
Cell Invasion ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Time Lapse ◽  
Oscillatory Behavior ◽  
Deleted In Colorectal Cancer ◽  
Family Protein ◽  
Anchor Cell

The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extracellular ligand netrin. How DCC polarizes toward netrin is poorly understood. By performing live-cell imaging of the DCC orthologue UNC-40 during anchor cell invasion in Caenorhabditis elegans, we have found that UNC-40 clusters, recruits F-actin effectors, and generates F-actin in the absence of UNC-6 (netrin). Time-lapse analyses revealed that UNC-40 clusters assemble, disassemble, and reform at periodic intervals in different regions of the cell membrane. This oscillatory behavior indicates that UNC-40 clusters through a mechanism involving interlinked positive (formation) and negative (disassembly) feedback. We show that endogenous UNC-6 and ectopically provided UNC-6 orient and stabilize UNC-40 clustering. Furthermore, the UNC-40–binding protein MADD-2 (a TRIM family protein) promotes ligand-independent clustering and robust UNC-40 polarization toward UNC-6. Together, our data suggest that UNC-6 (netrin) directs polarized responses by stabilizing UNC-40 clustering. We propose that ligand-independent UNC-40 clustering provides a robust and adaptable mechanism to polarize toward netrin.

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