scholarly journals Factors Associated With the Performance of Extended Colonic Resection vs. Segmental Resection in Early-Onset Colorectal Cancer: A Population-Based Study

2016 ◽  
Vol 7 (4) ◽  
pp. e163 ◽  
Author(s):  
Jordan J Karlitz ◽  
Meredith R Sherrill ◽  
Daniel V DiGiacomo ◽  
Mei-chin Hsieh ◽  
Beth Schmidt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Population Based ◽  
Segmental Resection ◽  
Colonic Resection ◽  
Population Based Study ◽  
Factors Associated ◽  
Early Onset Colorectal Cancer

scholarly journals Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Giulia Magnani ◽  
Daniela Furlan ◽  
Nora Sahnane ◽  
Luca Reggiani Bonetti ◽  
Federica Domati ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mismatch Repair ◽  
Early Onset ◽  
Methylation Status ◽  
The Elderly ◽  
Population Based ◽  
Repair System ◽  
Molecular Features ◽  
A Minor ◽  
Early Onset Colorectal Cancer

Colorectal cancer is usually considered a disease of the elderly. However, a small fraction of patients develops colorectal cancer earlier. The aim of our study was to define the frequency of known hereditary colorectal syndromes and to characterise genetic and epigenetic features of early nonhereditary tumors. Thirty-three patients ≤40 years with diagnosis of colorectal cancer and 41 patients with disease at >60 years of age were investigated for MSI, Mismatch Repair proteins expression,KRASandBRAFmutations, hypermethylation, and LINE-1 hypomethylation. Detection of germline mutations was performed in Mismatch Repair,APCandMUTYHgenes. Early onset colorectal cancer showed a high incidence of hereditary forms (18%).KRASmutations were detected in 36% of early nonhereditary tumors. Early onset colorectal cancer disclosed an average number of methylated genes significantly lower when compared to the controls (p=0.02). Finally both of the two groups were highly methylated inESR1,GATA5, andWT1genes and were similar for LINE-1 hypomethylation. The genetic make-up of carcinomas differs from young to elderly patients. Early onset tumors showed more frequently a constitutional defective of Mismatch Repair System and a minor number of methylated genes. Hypermethylation ofESR1,GATA5, andWT1genes suggests possible markers in the earlier diagnosis of colorectal tumorigenesis.

scholarly journals Risk Factors Associated With Early-Onset Colorectal Cancer

2020 ◽  
Vol 18 (12) ◽  
pp. 2752-2759.e2 ◽  
Author(s):  
Valerie Gausman ◽  
David Dornblaser ◽  
Sanya Anand ◽  
Richard B. Hayes ◽  
Kelli O'Connell ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Factors Associated ◽  
Early Onset Colorectal Cancer

scholarly journals AfterhMSH2 andhMLH1?what next? Analysis of three-generational, population-based, early-onset colorectal cancer families

2002 ◽  
Vol 102 (2) ◽  
pp. 166-171 ◽  
Author(s):  
Mark A. Jenkins ◽  
Laura Baglietto ◽  
Gillian S. Dite ◽  
Damien J. Jolley ◽  
Melissa C. Southey ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Population Based ◽  
Early Onset Colorectal Cancer

Patterns of colorectal cancer diagnosis among younger adults in a real-world, population-based cohort

2021 ◽  
pp. 00-00
Author(s):  
Omar Abdel-Rahman ◽  
Hatim Karachiwala ◽  
Sheryl Koski
Keyword(s):  
Colorectal Cancer ◽  
Early Onset ◽  
Population Based ◽  
Age At Diagnosis ◽  
Administrative Databases ◽  
Multivariable Logistic Regression Analysis ◽  
World Population ◽  
Factors Associated ◽  
Younger Age ◽  
South Zone

Aims: To review the patterns of early-onset (<50 years old) colorectal cancer (CRC) in Alberta across the past 15 years among different socioeconomic and demographic patient subgroups. Methods: This is a retrospective, population-based study based on Alberta administrative databases. Income level was identified via income information from the 2006 Canadian census. Patients with colorectal adenocarcinoma diagnosed 2004–2018 were included. Frequency analyses were used to examine the percentage of early-onset CRC cases among different subgroups over the period studied. Multivariable logistic regression analysis was used to examine factors associated with the development of early-onset CRC. Results: A total of 24,912 patients were included, of whom 2096 (8.4%) were diagnosed at age <50 years and 22,816 (91.6%) at age ≥50 years. The percentage of patients diagnosed at age <50 years increased over time (10.2% in 2018 vs 7.9% in 2004; p < 0.003). Higher income was associated with younger age at diagnosis of CRC (odds ratio [OR] for quartile 1 vs quartile 4: 0.54; 95% CI: 0.47–0.62). Other factors associated with younger age at diagnosis included female sex (OR for male vs female: 0.85; 95% CI: 0.78–0.94), distal CRC (OR: 1.66; 95% CI: 1.50–1.84) and North zone (OR for South zone vs North zone: 0.74; 95% CI: 0.60–0.92). Conclusion: The proportion of patients (out of the overall CRC population) with early-onset CRC, increased in Alberta throughout the study duration (particularly left-sided CRC). There is a need to reassess the current age limits for CRC screening in Canada in view of these findings.

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