scholarly journals Impaired functions of neural stem cells by abnormal nitric oxide-mediated signaling in an in vitro model of Niemann-Pick type C disease

Cell Research ◽  
2008 ◽  
Vol 18 (6) ◽  
pp. 686-694 ◽  
Author(s):  
Sun-Jung Kim ◽  
Myung-Sin Lim ◽  
Soo-Kyung Kang ◽  
Yong-Soon Lee ◽  
Kyung-Sun Kang
Keyword(s):  
Nitric Oxide ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
In Vitro Model ◽  
Type C ◽  
Vitro Model ◽  
Niemann Pick

scholarly journals ATM-deficient human neural stem cells as an in vitro model system to study neurodegeneration

DNA Repair ◽  
2013 ◽  
Vol 12 (8) ◽  
pp. 605-611 ◽  
Author(s):  
Luigi Carlessi ◽  
Elena Fusar Poli ◽  
Lidia De Filippis ◽  
Domenico Delia
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
In Vitro Model ◽  
Model System ◽  
Human Neural Stem Cells ◽  
In Vitro Model System ◽  
Vitro Model

T1736 An In Vitro Model to Study the Potential of Neural Stem Cells of Diverse Origins to Assume an Enteric Phenotype

2010 ◽  
Vol 138 (5) ◽  
pp. S-567-S-568 ◽  
Author(s):  
Subhash Kulkarni ◽  
Maria-Adelaide Micci ◽  
Gunjan Tiwari ◽  
Xinmin S. Xie ◽  
Pankaj J. Pasricha
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
In Vitro Model ◽  
Vitro Model

scholarly journals In Vitro Model of Mycobacterial Growth Arrest Using Nitric Oxide with Limited Air

2008 ◽  
Vol 53 (1) ◽  
pp. 157-161 ◽  
Author(s):  
Syed Hussain ◽  
Muhammad Malik ◽  
Lanbo Shi ◽  
Maria Laura Gennaro ◽  
Karl Drlica
Keyword(s):  
Nitric Oxide ◽  
In Vitro Model ◽  
Transition Period ◽  
Time Lag ◽  
Growth Arrest ◽  
Ring Structure ◽  
Time Lags ◽  
Vitro Model ◽  
Mycobacterial Growth

ABSTRACT An in vitro model of mycobacterial growth arrest was developed using Mycobacterium bovis BCG. When an exponentially growing culture was transferred to an evacuated tube, growth continued; treatment with a source of nitric oxide (diethylenetriamine-nitric oxide adduct [DETA-NO] at 50 μM) halted growth immediately, and aeration restored growth. When the period of growth arrest exceeded 4 h, a time lag occurred before aeration could restore growth. The lag time was maximal (24 h) after 16 h of growth arrest. These time lags indicated that one transition period was required for cells to achieve full arrest of growth and another for them to recover fully from growth arrest. DETA-NO-induced growth arrest failed to protect from the lethal effects of anaerobic shock, which caused rapid lysis of both growing and growth-arrested cells. While growth arrest had little effect on the lethal action of rifampin, it eliminated isoniazid lethality. Growth arrest reduced but did not eliminate fluoroquinolone lethality. Two fluoroquinolones, moxifloxacin and gatifloxacin, were equally lethal to exponentially growing cells, but moxifloxacin was more active during growth arrest. This difference is attributed to the fluoroquinolone C-7 ring structure, the only difference between the compounds. Collectively these data characterize a new system for halting mycobacterial growth that may be useful for evaluating new antituberculosis agents.

A scaffold-free in vitro model for osteogenesis of human mesenchymal stem cells

2011 ◽  
Vol 43 (2) ◽  
pp. 91-100 ◽  
Author(s):  
Cornelia Hildebrandt ◽  
Heiko Büth ◽  
Hagen Thielecke
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
In Vitro Model ◽  
Human Mesenchymal Stem Cells ◽  
Vitro Model
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