Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?

P Vicini; P H van der Graaf

doi:10.1038/clpt.2013.40

Systems Pharmacology for Drug Discovery and Development: Paradigm Shift or Flash in the Pan?

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2013.40 ◽

2013 ◽

Vol 93 (5) ◽

pp. 379-381 ◽

Cited By ~ 72

Author(s):

P Vicini ◽

P H van der Graaf

Keyword(s):

Drug Discovery ◽

Paradigm Shift ◽

Systems Pharmacology ◽

Drug Discovery And Development ◽

Development Paradigm

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Quantitative systems pharmacology for shifting the drug discovery and development paradigm

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1870 ◽

2013 ◽

Vol 34 (9) ◽

pp. 475-476 ◽

Cited By ~ 4

Keyword(s):

Drug Discovery ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

Drug Discovery And Development ◽

Development Paradigm

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Regenerative Medicine: Transforming the Drug Discovery and Development Paradigm

Cold Spring Harbor Perspectives in Medicine ◽

10.1101/cshperspect.a014084 ◽

2014 ◽

Vol 4 (8) ◽

pp. a014084-a014084 ◽

Cited By ~ 4

Author(s):

S. K. Karathanasis

Keyword(s):

Drug Discovery ◽

Regenerative Medicine ◽

Drug Discovery And Development ◽

Development Paradigm

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Translational Medicine – A Paradigm Shift in Modern Drug Discovery and Development

Biomarkers in Drug Discovery and Development ◽

10.1002/9781119187547.ch16 ◽

2020 ◽

pp. 333-345

Author(s):

Giora Z. Feuerstein ◽

Salvatore Alesci ◽

Frank L. Walsh ◽

J. Lynn Rutkowski ◽

Robert R. Ruffolo

Keyword(s):

Drug Discovery ◽

Paradigm Shift ◽

Translational Medicine ◽

Drug Discovery And Development ◽

Modern Drug

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Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development

Drug Discovery Today ◽

10.1016/j.drudis.2011.10.001 ◽

2011 ◽

Vol 16 (23-24) ◽

pp. 1031-1036 ◽

Cited By ~ 32

Author(s):

Balaji M. Agoram ◽

Oleg Demin

Keyword(s):

Drug Discovery ◽

Systems Pharmacology ◽

Drug Discovery And Development

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Next-Generation Model-Based Drug Discovery and Development: Quantitative and Systems Pharmacology

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2010.81 ◽

2010 ◽

Vol 88 (1) ◽

pp. 135-137 ◽

Cited By ~ 41

Author(s):

S R B Allerheiligen

Keyword(s):

Drug Discovery ◽

Generation Model ◽

Systems Pharmacology ◽

Next Generation ◽

Drug Discovery And Development ◽

Model Based

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Botanicals and its extracts: Anew drug discovery and development paradigm for chronic and age-related illnesses

Medical Research and Innovations ◽

10.15761/mri.1000131 ◽

2018 ◽

Vol 2 (1) ◽

Cited By ~ 1

Author(s):

Leodevico L. Ilag

Keyword(s):

Drug Discovery ◽

Drug Discovery And Development ◽

Age Related ◽

Development Paradigm

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Appendix I: Small Molecule Drug Discovery and Development Paradigm

Case Studies in Modern Drug Discovery and Development ◽

10.1002/9781118219683.app1 ◽

2012 ◽

pp. 417-418

Keyword(s):

Drug Discovery ◽

Small Molecule ◽

Drug Discovery And Development ◽

Small Molecule Drug ◽

Development Paradigm

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Reverse Pharmacology-A Paradigm Shift for Drug Discovery and Development

Current Research in Drug Discovery ◽

10.3844/crddsp.2014.39.44 ◽

2014 ◽

Vol 1 (2) ◽

pp. 39-44 ◽

Cited By ~ 7

Author(s):

Ashok D.B. Vaidya

Keyword(s):

Drug Discovery ◽

Paradigm Shift ◽

Drug Discovery And Development

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Better prediction of the local concentration–effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development

Drug Discovery Today ◽

10.1016/j.drudis.2019.05.016 ◽

2019 ◽

Vol 24 (7) ◽

pp. 1344-1354 ◽

Cited By ~ 6

Author(s):

Sebastian Polak ◽

Zofia Tylutki ◽

Mark Holbrook ◽

Barbara Wiśniowska

Keyword(s):

Drug Discovery ◽

Local Concentration ◽

Systems Pharmacology ◽

Physiologically Based Pharmacokinetics ◽

Quantitative Systems Pharmacology ◽

Drug Discovery And Development ◽

Effect Relationship ◽

Physiologically Based ◽

Pharmacology And Toxicology

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Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12478 ◽

2019 ◽

Vol 9 (1) ◽

pp. 5-20 ◽

Cited By ~ 9

Author(s):

Hugo Geerts ◽

John Wikswo ◽

Piet H. Graaf ◽

Jane P.F. Bai ◽

Chris Gaiteri ◽

...

Keyword(s):

Drug Discovery ◽

Current Status ◽

Systems Pharmacology ◽

Quantitative Systems Pharmacology ◽

Drug Discovery And Development

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