Next-Generation Model-Based Drug Discovery and Development: Quantitative and Systems Pharmacology

2010 ◽  
Vol 88 (1) ◽  
pp. 135-137 ◽  
Author(s):  
S R B Allerheiligen
Keyword(s):  
Drug Discovery ◽  
Generation Model ◽  
Systems Pharmacology ◽  
Next Generation ◽  
Drug Discovery And Development ◽  
Model Based

The application of next-generation sequencing technologies to drug discovery and development

2011 ◽  
Vol 16 (11-12) ◽  
pp. 512-519 ◽  
Author(s):  
Peter M. Woollard ◽  
Nalini A.L. Mehta ◽  
Jessica J. Vamathevan ◽  
Stephanie Van Horn ◽  
Bhushan K. Bonde ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Drug Discovery ◽  
Next Generation ◽  
Drug Discovery And Development ◽  
Sequencing Technologies ◽  
Generation Sequencing

scholarly journals Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics

2017 ◽  
Vol 12 (12) ◽  
pp. 1207-1218 ◽  
Author(s):  
Elizabeth C. M. de Lange ◽  
Willem van den Brink ◽  
Yumi Yamamoto ◽  
Wilhelmus E. A. de Witte ◽  
Yin Cheong Wong
Keyword(s):  
Drug Discovery ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Drug Discovery And Development ◽  
Model Based ◽  
Development Approach

scholarly journals Role of pharmaceutical sciences in future drug discovery

2021 ◽  
Vol 3 (3) ◽  
Author(s):  
Srinivasa Reddy Bonam ◽  
Mahendran Sekar ◽  
Girija S Guntuku ◽  
Sridhar G Nerella ◽  
Krishna M Pawar A ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Translational Research ◽  
Pharmacy Education ◽  
Pharmaceutical Sciences ◽  
Next Generation ◽  
Drug Discovery And Development ◽  
Recent Emergence ◽  
Future Drug

The recent emergence of COVID-19 influenced the layman’s knowledge of drugs. Although several drugs have been discovered serendipitously, research has moved to the next-generation era of drug discovery. The use of drugs is inevitable and they have become lifesavers in the present era. Although research from different scientific backgrounds has supported the translational research of drug discovery, the prime role of pharmacy has to be remembered. Here we have summarized the role of some important subjects in pharmacy education, which have paved different ways in drug discovery and development.

scholarly journals A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine

2016 ◽  
Vol 21 (6) ◽  
pp. 521-534 ◽  
Author(s):  
Andrew M. Stern ◽  
Mark E. Schurdak ◽  
Ivet Bahar ◽  
Jeremy M. Berg ◽  
D. Lansing Taylor
Keyword(s):  
Drug Discovery ◽  
Personalized Medicine ◽  
Disease Progression ◽  
Development Strategy ◽  
Population Based ◽  
Resistance Mechanisms ◽  
Therapeutic Strategies ◽  
Systems Pharmacology ◽  
Quantitative Systems Pharmacology ◽  
Drug Discovery And Development

Drug candidates exhibiting well-defined pharmacokinetic and pharmacodynamic profiles that are otherwise safe often fail to demonstrate proof-of-concept in phase II and III trials. Innovation in drug discovery and development has been identified as a critical need for improving the efficiency of drug discovery, especially through collaborations between academia, government agencies, and industry. To address the innovation challenge, we describe a comprehensive, unbiased, integrated, and iterative quantitative systems pharmacology (QSP)–driven drug discovery and development strategy and platform that we have implemented at the University of Pittsburgh Drug Discovery Institute. Intrinsic to QSP is its integrated use of multiscale experimental and computational methods to identify mechanisms of disease progression and to test predicted therapeutic strategies likely to achieve clinical validation for appropriate subpopulations of patients. The QSP platform can address biological heterogeneity and anticipate the evolution of resistance mechanisms, which are major challenges for drug development. The implementation of this platform is dedicated to gaining an understanding of mechanism(s) of disease progression to enable the identification of novel therapeutic strategies as well as repurposing drugs. The QSP platform will help promote the paradigm shift from reactive population-based medicine to proactive personalized medicine by focusing on the patient as the starting and the end point.

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