Predicting Drug Interaction Potential With a Physiologically Based Pharmacokinetic Model: A Case Study of Telithromycin, a Time-Dependent CYP3A Inhibitor

Md L T Vieira; P Zhao; E G Berglund; K S Reynolds; L Zhang; L J Lesko; S-M Huang

doi:10.1038/clpt.2011.305

Predicting Drug Interaction Potential With a Physiologically Based Pharmacokinetic Model: A Case Study of Telithromycin, a Time-Dependent CYP3A Inhibitor

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2011.305 ◽

2012 ◽

Vol 91 (4) ◽

pp. 700-708 ◽

Cited By ~ 34

Author(s):

Md L T Vieira ◽

P Zhao ◽

E G Berglund ◽

K S Reynolds ◽

L Zhang ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Cyp3a Inhibitor

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Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.01.007 ◽

2017 ◽

Vol 106 (5) ◽

pp. 1439-1451 ◽

Cited By ~ 11

Author(s):

Wen Lin ◽

Tao Ji ◽

Heidi Einolf ◽

Surya Ayalasomayajula ◽

Tsu-Han Lin ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2122 ◽

2018 ◽

Vol 39 (3) ◽

pp. 152-163 ◽

Cited By ~ 6

Author(s):

Ken-ichi Umehara ◽

Felix Huth ◽

Christina S. Won ◽

Tycho Heimbach ◽

Handan He

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 2: Investigating Interaction Potential Using a Physiologically Based Pharmacokinetic Model

Clinical Pharmacokinetics ◽

10.1007/s40262-020-00881-3 ◽

2020 ◽

Vol 59 (9) ◽

pp. 1149-1160 ◽

Cited By ~ 1

Author(s):

An Van den Bergh ◽

Jan Snoeys ◽

Loeckie De Zwart ◽

Peter Ward ◽

Angela Lopez-Gitlitz ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Pharmacokinetic Drug

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Evaluation of drug‐drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically‐based pharmacokinetic model

Clinical and Translational Science ◽

10.1111/cts.13118 ◽

2021 ◽

Author(s):

Ashit Trivedi ◽

Winnie Sohn ◽

Priyanka Kulkarni ◽

Pegah Jafarinasabian ◽

Hanze Zhang ◽

...

Keyword(s):

Drug Interaction ◽

Clinical Study ◽

Interaction Potential ◽

Healthy Subjects ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Omecamtiv Mecarbil ◽

Drug Drug Interaction

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Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

BMC Systems Biology ◽

10.1186/s12918-017-0513-2 ◽

2017 ◽

Vol 11 (S7) ◽

Cited By ~ 1

Author(s):

Shun Asami ◽

Daisuke Kiga ◽

Akihiko Konagaya

Keyword(s):

Newton Method ◽

Perturbation Analysis ◽

Pharmacokinetic Model ◽

Whole Body ◽

Physiologically Based Pharmacokinetic Model ◽

Parameter Estimations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

Clinical Pharmacokinetics ◽

10.1007/s40262-019-00856-z ◽

2019 ◽

Vol 59 (6) ◽

pp. 781-808 ◽

Cited By ~ 5

Author(s):

Xia Li ◽

Sebastian Frechen ◽

Daniel Moj ◽

Thorsten Lehr ◽

Max Taubert ◽

...

Keyword(s):

Drug Interactions ◽

Genetic Polymorphisms ◽

Pharmacokinetic Model ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Assessment of drug–drug interaction and optimization in capecitabine and irinotecan combination regimen using a physiologically based pharmacokinetic model

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2021.12.021 ◽

2021 ◽

Author(s):

Shuhei Sakai ◽

Shinji Kobuchi ◽

Yukako Ito ◽

Toshiyuki Sakaeda

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Combination Regimen ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes

Xenobiotica ◽

10.1080/00498254.2017.1370744 ◽

2017 ◽

Vol 48 (8) ◽

pp. 770-780 ◽

Cited By ~ 1

Author(s):

Shinji Iwasaki ◽

Hideki Hirabayashi ◽

Nobuyuki Amano

Keyword(s):

Drug Interaction ◽

Drug Metabolism ◽

Pharmacokinetic Model ◽

Quantitative Prediction ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz

In Silico Pharmacology ◽

10.1186/2193-9616-1-4 ◽

2013 ◽

Vol 1 (1) ◽

Cited By ~ 20

Author(s):

Marco Siccardi ◽

Adeniyi Olagunju ◽

Kay Seden ◽

Farid Ebrahimjee ◽

Steve Rannard ◽

...

Keyword(s):

Drug Interaction ◽

Dose Adjustment ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Korean Journal of Physiology and Pharmacology ◽

10.4196/kjpp.2017.21.1.107 ◽

2017 ◽

Vol 21 (1) ◽

pp. 107 ◽

Cited By ~ 8

Author(s):

Min-Ho Park ◽

Seok-Ho Shin ◽

Jin-Ju Byeon ◽

Gwan-Ho Lee ◽

Byung-Yong Yu ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pbpk Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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