Therapeutic Protein–Drug Interactions and Implications for Drug Development

2010 ◽  
Vol 87 (4) ◽  
pp. 497-503 ◽  
Author(s):  
S-M Huang ◽  
H Zhao ◽  
J-I Lee ◽  
K Reynolds ◽  
L Zhang ◽  
...  
Keyword(s):  
Drug Development ◽  
Drug Interactions ◽  
Therapeutic Protein ◽  
Protein Drug

CYP-Mediated Therapeutic Protein-Drug Interactions

2010 ◽  
Vol 49 (5) ◽  
pp. 295-310 ◽  
Author(s):  
Jang-Ik Lee ◽  
Lei Zhang ◽  
Angela Y. Men ◽  
Leslie A. Kenna ◽  
Shiew-Mei Huang
Keyword(s):  
Drug Interactions ◽  
Therapeutic Protein ◽  
Protein Drug

scholarly journals AAPS Workshop Report: Strategies to Address Therapeutic Protein–Drug Interactions during Clinical Development

2011 ◽  
Vol 13 (3) ◽  
pp. 405-416 ◽  
Author(s):  
Sandhya Girish ◽  
Steven W Martin ◽  
Mark C Peterson ◽  
Lei K. Zhang ◽  
Hong Zhao ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Clinical Development ◽  
Therapeutic Protein ◽  
Protein Drug ◽  
Workshop Report

Highlights From a Recent BIO Survey on Therapeutic Protein-Drug Interactions

2012 ◽  
Vol 52 (11) ◽  
pp. 1755-1763 ◽  
Author(s):  
◽  
Peter Lloyd ◽  
Honghui Zhou ◽  
Frank-Peter Theil ◽  
Tarundeep Kakkar ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Therapeutic Protein ◽  
Protein Drug

Utility of population pharmacokinetic modeling in the assessment of therapeutic protein-drug interactions

2013 ◽  
Vol 54 (5) ◽  
pp. 593-601 ◽  
Author(s):  
Andrew T. Chow ◽  
Justin C. Earp ◽  
Manish Gupta ◽  
William Hanley ◽  
Chuanpu Hu ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Pharmacokinetic Modeling ◽  
Therapeutic Protein ◽  
Population Pharmacokinetic ◽  
Protein Drug ◽  
Population Pharmacokinetic Modeling

scholarly journals Recent advances in (therapeutic protein) drug development

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 113 ◽  
Author(s):  
H.A. Daniel Lagassé ◽  
Aikaterini Alexaki ◽  
Vijaya L. Simhadri ◽  
Nobuko H. Katagiri ◽  
Wojciech Jankowski ◽  
...  
Keyword(s):  
Drug Development ◽  
Genetic Disorders ◽  
Therapeutic Protein ◽  
Protein Drug ◽  
Important Class ◽  
Infectious Agents ◽  
Emerging Trends ◽  
Recombinant Protein Therapeutics ◽  
Fine Tune ◽  
The U.S

Therapeutic protein drugs are an important class of medicines serving patients most in need of novel therapies. Recently approved recombinant protein therapeutics have been developed to treat a wide variety of clinical indications, including cancers, autoimmunity/inflammation, exposure to infectious agents, and genetic disorders. The latest advances in protein-engineering technologies have allowed drug developers and manufacturers to fine-tune and exploit desirable functional characteristics of proteins of interest while maintaining (and in some cases enhancing) product safety or efficacy or both. In this review, we highlight the emerging trends and approaches in protein drug development by using examples of therapeutic proteins approved by the U.S. Food and Drug Administration over the previous five years (2011–2016, namely January 1, 2011, through August 31, 2016).

scholarly journals Therapeutic Protein Drug–Drug Interactions: Navigating the Knowledge Gaps–Highlights from the 2012 AAPS NBC Roundtable and IQ Consortium/FDA Workshop

2013 ◽  
Vol 15 (4) ◽  
pp. 933-940 ◽  
Author(s):  
Jane R. Kenny ◽  
Maggie M. Liu ◽  
Andrew T. Chow ◽  
Justin C. Earp ◽  
Raymond Evers ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Therapeutic Protein ◽  
Protein Drug ◽  
Knowledge Gaps
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