ABC Transporters in Drug-Refractory Epilepsy: Limited Clinical Significance of Pharmacogenetics?

2010 ◽  
Vol 87 (1) ◽  
pp. 15-18 ◽  
Author(s):  
I Cascorbi
Keyword(s):  
Clinical Significance ◽  
Abc Transporters ◽  
Refractory Epilepsy ◽  
Drug Refractory Epilepsy

scholarly journals Transporters in Drug-Refractory Epilepsy: Clinical Significance

2010 ◽  
Vol 87 (1) ◽  
pp. 13-15 ◽  
Author(s):  
N Marchi ◽  
J Gonzalez-Martinez ◽  
M-T Nguyen ◽  
T Granata ◽  
D Janigro
Keyword(s):  
Clinical Significance ◽  
Refractory Epilepsy ◽  
Drug Refractory Epilepsy

Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy

2018 ◽  
Vol 17 (10) ◽  
pp. 728-735 ◽  
Author(s):  
Xiaolin Deng ◽  
Yangmei Xie ◽  
Yinghui Chen
Keyword(s):  
Antiepileptic Drugs ◽  
Abc Transporters ◽  
Refractory Epilepsy ◽  
Vascular Endothelial Cells ◽  
Efflux Transporters ◽  
Vascular Endothelial ◽  
Intracellular Signalling Pathways ◽  
The Brain ◽  
Transporter Expression

Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways. Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.

scholarly journals Epilepsy in children with perinatal arterial ischemic stroke

2021 ◽  
Author(s):  
Fabienne Kühne ◽  
Alexander Jungbluth ◽  
Joanna Schneider ◽  
Christoph Bührer ◽  
Christine Prager ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Ischemic Stroke ◽  
Neonatal Period ◽  
Refractory Epilepsy ◽  
Late Onset ◽  
Cognitive Outcome ◽  
Response To Treatment ◽  
Arterial Ischemic Stroke ◽  
Structural Epilepsy ◽  
Drug Refractory Epilepsy

Purpose: Perinatal ischemic stroke (PIS) is a frequent cause for perinatal brain structure defects resulting in epilepsy, cerebral palsy and disability. Since the severity of symptoms is variable, the aim of this study was to evaluate the outcome of children with PIS and seizures/epilepsy to aid parental counseling and therapy decisions. Material: We studied retrospectively patients with arterial PIS and structural epilepsy or seizures in the newborn treated at a single center in 2000-2019. Specifically, signs and symptoms of cerebral palsy (CP), developmental and motor delay, epilepsy and thrombophilia were assessed. Results: From the identified 69 individuals with arterial PIS, we only included the 50 patients (64% male) who had structural epilepsy at the time of investigation or previously in their medical history.The mean age of the included patients was 7.1 years (range 0.08-22) at last consultation. Infarct localisation was predominantly unilateral (86%), left sided (58%) and affecting the middle cerebral artery (94%). Genetic thrombophilia was identified in 52% of the patients examined with genetic testing. More than half of the individuals had CP (52%), and 38.5% had a cognitive outcome below average. First seizures occurred in the neonatal period in 58% of patients and developed into drug-refractory epilepsy in 24.1%. Children with late-onset of epilepsy were twice as likely to develop drug-refractory epilepsy (52.4%). Discussion: Our study shows that patients with PIS and seizures as common sequela often also develop CP. Children with later onset of epilepsy have a worse outcome. Patients with seizure onset in the neonatal period and reccuring seizures have a good response to treatment. Therefore, early diagnosis, follow-up examination and adequate therapy are important. Most children need intensive physiotherapy and speech therapy; however, participation in life is usually age-appropriate.

Clinical spectrum of pediatric drug refractory epilepsy secondary to parieto-occipital gliosis

2021 ◽  
pp. 106804
Author(s):  
Somdattaa Ray ◽  
Raghavendra Kenchaiah ◽  
Ajay Asranna ◽  
Hansashree Padmanabha ◽  
Karthik Kulanthaivelu ◽  
...  
Keyword(s):  
Refractory Epilepsy ◽  
Clinical Spectrum ◽  
Pediatric Drug ◽  
Drug Refractory Epilepsy

STN–PPTg circuits and REM sleep dysfunction in drug-refractory epilepsy

2015 ◽  
Vol 51 ◽  
pp. 277-280 ◽  
Author(s):  
Ai-Jun Xu ◽  
Tao-Tao Liu ◽  
Zhi-Gang He ◽  
Qing-Xiong Hong ◽  
Hong-Bing Xiang
Keyword(s):  
Rem Sleep ◽  
Refractory Epilepsy ◽  
Sleep Dysfunction ◽  
Drug Refractory Epilepsy

Investigation of altered microstructure in patients with drug refractory epilepsy using diffusion tensor imaging

2017 ◽  
Vol 59 (6) ◽  
pp. 597-608 ◽  
Author(s):  
Yuwei Jiang ◽  
Lingyan Mao ◽  
Xu Yan ◽  
Mingxia Fan ◽  
Xin Wang ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Refractory Epilepsy ◽  
Diffusion Tensor ◽  
Drug Refractory Epilepsy

scholarly journals Effect of reduction of antiepileptic drugs in patients with drug-refractory epilepsy

Seizure ◽  
2015 ◽  
Vol 27 ◽  
pp. 25-29 ◽  
Author(s):  
Deepa Dash ◽  
Vikas Aggarwal ◽  
Rupa Joshi ◽  
Madakasira Vasantha Padma ◽  
Manjari Tripathi
Keyword(s):  
Antiepileptic Drugs ◽  
Refractory Epilepsy ◽  
Drug Refractory Epilepsy
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