Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans

2008 ◽  
Vol 84 (4) ◽  
pp. 481-487 ◽  
Author(s):  
M Liem-Moolenaar ◽  
D Cerneus ◽  
CJ Molloy ◽  
D End ◽  
KH Brown ◽  
...  
Keyword(s):  
The Novel ◽  
Mimetic Peptide ◽  
Thrombopoietin Mimetic Peptide ◽  
Thrombopoietin Mimetic

The Cardioprotective Properties of the Novel 5A Apolipoprotein A-I Mimetic Peptide are Mediated via the ABCA1 Transporter

2009 ◽  
Vol 18 ◽  
pp. S124
Author(s):  
F. Tabet ◽  
A.T. Remaley ◽  
P.J. Barter ◽  
K.A. Rye ◽  
G. Lambert
Keyword(s):  
The Novel ◽  
Mimetic Peptide ◽  
Apolipoprotein A

scholarly journals Mitigation of Total Body Irradiation-Induced Mortality and Hematopoietic Injury of Mice by a Thrombopoietin Mimetic (JNJ-26366821)

2021 ◽  
Author(s):  
Vidya P. Kumar ◽  
Gregory P. Holmes-Hampton ◽  
Shukla Biswas ◽  
Sasha Stone ◽  
Neel Kamal Sharma ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Enhanced Recovery ◽  
Probit Analysis ◽  
Reduction Factor ◽  
Control Treatment ◽  
Saline Control ◽  
Thrombopoietin Mimetic Peptide ◽  
Total Body ◽  
Thrombopoietin Mimetic ◽  
The Impact

Abstract The threat of a nuclear attack has increased in recent years highlighting the benefit of developing additional therapies for the treatment of victims suffering from Acute Radiation Syndrome (ARS). In this work, we evaluated the impact of a PEGylated thrombopoietin mimetic peptide, JNJ-26366821, on the mortality and hematopoietic effects associated with ARS in mice exposed to lethal doses of total body irradiation (TBI). JNJ-26366821 was efficacious as a mitigator of mortality and thrombocytopenia associated with ARS in both CD2F1 and C57BL/6 mice exposed to TBI from a cobalt-60 gamma-ray source. Single administration of doses ranging from 0.3 to 1 mg/kg, given 4, 8, 12 or 24 hours post-TBI (LD70 dose) increased survival by 30 – 90% as compared to saline control treatment. At the conclusion of the 30-day study, significant increases in bone marrow colony forming units and megakaryocytes were observed in animals administered JNJ-26366821 compared to those administered saline. In addition, enhanced recovery of FLT3-L levels was observed in JNJ-26366821-treated animals. Probit analysis of survival in the JNJ-26366821- and saline-treated cohorts revealed a dose reduction factor of 1.113 and significant increases in survival for up to 6 months following irradiation. These results support the potential use of JNJ-26366821 as a medical countermeasure for treatment of acute TBI exposure in case of a radiological/nuclear event when administered from 4 to 24 hours post-TBI.

T1809 The Novel Anti-Inflammatory Apoe-Mimetic Peptide COG112 Inhibits Helicobacter pylori-Stimulated Interleukin-8 Expression in Gastric Epithelial Cells

2008 ◽  
Vol 134 (4) ◽  
pp. A-568
Author(s):  
Stephanie M. Cauble ◽  
Mohammad Asim ◽  
Rupesh Chaturvedi ◽  
Daniel P. Barry ◽  
Nuruddeen D. Lewis ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Interleukin 8 ◽  
The Novel ◽  
Gastric Epithelial Cells ◽  
Mimetic Peptide ◽  
Anti Inflammatory

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
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