scholarly journals Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and an E1B deletion to drive IL-24 expression

2012 ◽  
Vol 19 (9) ◽  
pp. 619-629 ◽  
Author(s):  
K-J Zhang ◽  
J Zhang ◽  
Y-M Wu ◽  
J Qian ◽  
X-J Liu ◽  
...  
Keyword(s):  
Oncolytic Adenovirus ◽  
Complete Eradication ◽  
Afp Promoter

scholarly journals Complete Eradication of Xenograft Hepatoma by Oncolytic Adenovirus ZD55 Harboring TRAIL-IETD-Smac Gene with Broad Antitumor Effect

2012 ◽  
Vol 23 (9) ◽  
pp. 992-1002 ◽  
Author(s):  
Shi-bing Wang ◽  
Yuan Tan ◽  
Wen Lei ◽  
Yi-gang Wang ◽  
Xiu-mei Zhou ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Oncolytic Adenovirus ◽  
Complete Eradication

The oncolytic adenovirus Ad-iREP-2 utilizes p53-dependent rna interference for tumor-selective replication

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
E Gürlevik ◽  
P Schache ◽  
L Zender ◽  
MP Manns ◽  
S Kubicka ◽  
...  
Keyword(s):  
Rna Interference ◽  
Oncolytic Adenovirus ◽  
Tumor Selective

scholarly journals Complete eradication of chronic lymphocytic leukemia with unusual skin involvement of high mitotic index after time‐limited venetoclax/obinutuzumab treatment

2021 ◽  
Vol 9 (7) ◽  
Author(s):  
Maria Dimou ◽  
Theodoros Iliakis ◽  
Vasileios Paradalis ◽  
Aikaterini Bitsani ◽  
Marie‐Christine Kyrtsonis ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mitotic Index ◽  
Lymphocytic Leukemia ◽  
Skin Involvement ◽  
Complete Eradication

Caste and Untouchability in Jawaharlal Nehru’s Literary Masterpieces

2021 ◽  
pp. 2455328X2110093
Author(s):  
Tahira Tashneem
Keyword(s):  
Social Structure ◽  
Caste System ◽  
Indian Culture ◽  
Complete Eradication ◽  
Political Discourses ◽  
The World

As one of the major pillars of Indian social structure, the caste system distinguishes Indian culture from all other cultures of the world. Though the Constitution of India assures equality of status and opportunity for all citizens and various academic and political discourses also appealed for the complete eradication of the caste system, it has not been eradicated even after five decades of democracy. In this context, it becomes really interesting to re-examine the views on caste as reflected in Jawaharlal Nehru’s prose writings. Nehru’s major prose works unquestionably delineate his concern for caste. Focusing mainly on An Autobiography and the Discovery of India, this article seeks to examine the different representations of caste in his prose works and will also try to locate the gaps and the shifts underlying his views on caste.

scholarly journals Enhanced anti-melanoma efficacy through a combination of the armed oncolytic adenovirus ZD55-IL-24 and immune checkpoint blockade in B16-bearing immunocompetent mouse model

2021 ◽  
Author(s):  
Hai-Jun Hu ◽  
Xiu Liang ◽  
Hai-Lang Li ◽  
Huai-Yuan Wang ◽  
Jin-Fa Gu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Mouse Model ◽  
Immune Checkpoint Blockade ◽  
Oncolytic Adenovirus ◽  
Immunocompetent Mouse ◽  
Combination Strategy ◽  
Obvious Effect ◽  
Immune Infiltration ◽  
Synergistic Inhibition ◽  
Recent Treatment

AbstractAlthough the recent treatment in melanoma through the use of anti-PD-1 immunotherapy is successful, the efficacy of this approach remains to be improved. Here, we explore the feasibility of combination strategy with the armed oncolytic adenovirus ZD55-IL-24 and PD-1 blockade. We find that combination therapy with localized ZD55-IL-24 and systemic PD-1 blockade leads to synergistic inhibition of both local and distant established tumors in B16-bearing immunocompetent mouse model. Our further mechanism investigation reveals that synergistic therapeutic effect is associated with marked promotion of tumor immune infiltration and recognition in both local and distant tumors as well as spleens. PD-1 blockade has no obvious effect on promotion of tumor immune infiltration and recognition. Localized therapy with ZD55-IL-24, however, can help PD-1 blockade to overcome the limitation of relatively low tumor immune infiltration and recognition. This study provides a rationale for investigation of such combination therapy in the clinic.

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