scholarly journals Oncolytic adenovirus armed with human papillomavirus E2 gene in combination with radiation demonstrates synergistic enhancements of antitumor efficacy

2011 ◽  
Vol 18 (11) ◽  
pp. 825-836 ◽  
Author(s):  
W Wang ◽  
X Xia ◽  
S Wang ◽  
N Sima ◽  
Y Li ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Oncolytic Adenovirus ◽  
Antitumor Efficacy ◽  
E2 Gene

scholarly journals Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of theMDR1promoter activity

Oncotarget ◽  
2015 ◽  
Vol 6 (35) ◽  
pp. 38308-38326 ◽  
Author(s):  
Bing-Hua Su ◽  
Gia-Shing Shieh ◽  
Yau-Lin Tseng ◽  
Ai-Li Shiau ◽  
Chao-Liang Wu
Keyword(s):  
Oncolytic Adenovirus ◽  
Antitumor Efficacy

scholarly journals The antitumor efficacy of IL-24 mediated by E1A and E1B triple regulated oncolytic adenovirus

2010 ◽  
Vol 10 (3) ◽  
pp. 242-250 ◽  
Author(s):  
Lian Li Xiao ◽  
Yu Mei Wu ◽  
Jing Qian ◽  
Yuan Tan ◽  
Guo Liang Xie ◽  
...  
Keyword(s):  
Oncolytic Adenovirus ◽  
Antitumor Efficacy

scholarly journals Detailed Characteristics of Tonsillar Tumors with Extrachromosomal or Integrated Form of Human Papillomavirus

Viruses ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 42
Author(s):  
Barbora Pokrývková ◽  
Martina Saláková ◽  
Jana Šmahelová ◽  
Zuzana Vojtěchová ◽  
Vendula Novosadová ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Binding Sites ◽  
Viral Genome ◽  
Sanger Sequencing ◽  
Gene Methylation ◽  
Viral Oncogenes ◽  
E2 Gene ◽  
Viral Carcinogenesis ◽  
Transformation Mechanisms ◽  
Carcinogenic Process

The human papillomavirus (HPV) integration, the critical step in viral carcinogenesis, most frequently occurs in the E2 gene, which results in its inactivation and in an increase of E6/E7 transcription. However, in a substantial number of tumors, the virus is present in an extrachromosomal form. For those tumors, the transformation mechanisms are not fully elucidated. Here we evaluated the possible mechanism of inactivating the E2 without interruption of the gene, methylation or mutation of the E2 binding sites (E2BSs) in HPV16-positive tonsillar tumors by next-generation and Sanger sequencing. Viral genome status was analyzed by the amplification of papillomavirus oncogene transcripts assay (APOT) and mRNA mapping, and expression of viral oncogenes was performed by qPCR. The methylation of E2BSs was significantly higher in tumors with an integrated, in comparison to extrachromosomal, form of the viral genome. No mutations were detected in the E2BSs. The viral oncogenes were equally expressed in samples with an integrated and extrachromosomal form of the virus. Only the nucleotide variants were identified in the E2 gene. No proposed mechanism of E2 inactivation was confirmed in tonsillar tumors with an extrachromosomal form of the HPV genome. The expression of E6/E7 genes seems to be sufficient to initiate and maintain the carcinogenic process

scholarly journals Strong antitumor efficacy of a pancreatic tumor-targeting oncolytic adenovirus for neuroendocrine tumors

2017 ◽  
Vol 6 (10) ◽  
pp. 2385-2397 ◽  
Author(s):  
Yuki Yamamoto ◽  
Masaki Nagasato ◽  
Yosei Rin ◽  
Marina Henmi ◽  
Yoshinori Ino ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Tumor Targeting ◽  
Pancreatic Tumor ◽  
Oncolytic Adenovirus ◽  
Antitumor Efficacy

Potent Antitumor Efficacy of ST13 for Colorectal Cancer Mediated by Oncolytic Adenovirus via Mitochondrial Apoptotic Cell Death

2008 ◽  
Vol 19 (4) ◽  
pp. 343-353 ◽  
Author(s):  
Min Yang ◽  
Xin Cao ◽  
Ming Can Yu ◽  
Jin Fa Gu ◽  
Zong Hou Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Oncolytic Adenovirus ◽  
Apoptotic Cell Death ◽  
Antitumor Efficacy

scholarly journals Heat Increases the Editing Efficiency of Human Papillomavirus E2 Gene by Inducing Upregulation of APOBEC3A and 3G

2017 ◽  
Vol 137 (4) ◽  
pp. 810-818 ◽  
Author(s):  
Yang Yang ◽  
Hexiao Wang ◽  
Xinrui Zhang ◽  
Wei Huo ◽  
Ruiqun Qi ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Editing Efficiency ◽  
E2 Gene
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