Potent Antitumor Efficacy of ST13 for Colorectal Cancer Mediated by Oncolytic Adenovirus via Mitochondrial Apoptotic Cell Death

2008 ◽  
Vol 19 (4) ◽  
pp. 343-353 ◽  
Author(s):  
Min Yang ◽  
Xin Cao ◽  
Ming Can Yu ◽  
Jin Fa Gu ◽  
Zong Hou Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Oncolytic Adenovirus ◽  
Apoptotic Cell Death ◽  
Antitumor Efficacy

scholarly journals Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells

2017 ◽  
Vol 8 (10) ◽  
pp. e3087-e3087 ◽  
Author(s):  
Sen Wang ◽  
Kexin Wang ◽  
Chundong Zhang ◽  
Wanfeng Zhang ◽  
Qian Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Betulinic Acid ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Colorectal Cancer Cells

Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo

2018 ◽  
Vol 233 (9) ◽  
pp. 7134-7142 ◽  
Author(s):  
Long-Bin Jeng ◽  
Bharath Kumar Velmurugan ◽  
Ming-Cheng Chen ◽  
Hsi-Hsien Hsu ◽  
Tsung-Jung Ho ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Colorectal Cancer Cells

A survivin-mediated oncolytic adenovirus induces non-apoptotic cell death in lung cancer cells and shows antitumoral potentialin vivo

2006 ◽  
Vol 8 (10) ◽  
pp. 1232-1242 ◽  
Author(s):  
Binghua Li ◽  
Xinran Liu ◽  
Junkai Fan ◽  
Rong Qi ◽  
Linan Bo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Oncolytic Adenovirus ◽  
Apoptotic Cell Death ◽  
Lung Cancer Cells

scholarly journals Novel oncolytic adenovirus sensitizes renal cell carcinoma cells to radiotherapy via mitochondrial apoptotic cell death

2014 ◽  
Vol 11 (3) ◽  
pp. 2141-2146 ◽  
Author(s):  
REN-FU CHEN ◽  
YUE-YAN LI ◽  
LIAN-TAO LI ◽  
QIAN CHENG ◽  
GUAN JIANG ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Death ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Apoptotic Cell ◽  
Oncolytic Adenovirus ◽  
Apoptotic Cell Death ◽  
Carcinoma Cells

Altholactone Induces Apoptotic Cell Death in Human Colorectal Cancer Cells

2011 ◽  
Vol 26 (6) ◽  
pp. 926-931 ◽  
Author(s):  
Nizar M. Mhaidat ◽  
Kalid K. Abdul-Razzak ◽  
Ahmad S. Alkofahi ◽  
Aseera M. Alsarhan ◽  
Ahmad N. Aldaher ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

Demethylzeylasteral Exerts Antitumor Effects via Disruptive Autophagic Flux and Apoptotic Cell Death in Human Colorectal Cancer Cells and Increases Cell Chemosensitivity to 5-Fluorouracil

2021 ◽  
Vol 21 ◽  
Author(s):  
Guiyuan Liu ◽  
Dengxiang Lai ◽  
Yi Jiang ◽  
Hongjing Yang ◽  
Hui Zhao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Autophagic Flux ◽  
Human Colorectal Cancer ◽  
Antitumor Effects ◽  
Tripterygium Wilfordii Hook F ◽  
Pharmacologically Active

Background: Demethylzeylasteral (ZST93), a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF), has been reported to exert antineoplastic effects in several cancer cell types. However, the anti-tumour effects of ZST93 in human colorectal cancer (CRC) cells are unknown. Objective: The aim of the present study was to evaluate the antitumor effects of ZST93 on cell cycle arrest, disruptive autophagic flux, apoptotic cell death, and enhanced chemosensitivity to 5-FU in humans CRC cells. Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay, colony formation assay, flow cytometry, immunoblotting, immunofluorescence, 5-ethynyl-20-deoxyuridine (EdU) incorporation assay, and autophagy analysis were used to evaluate the effects of ZST93 on cell viability, cell cycle progression, apoptosis and autophagy in two human CRC cell lines. Moreover, ZST93’s combined anti-tumour effects with 5-fluorouracil (5-FU) were evaluated. Results: ZST93 inhibited CRC cell proliferation and growth. It was responsible for blocked cell cycle transition by arresting CRC cells in the G0/G1 phase via down-regulation of CDK4, CDK6, Cyclin D1, and c-MYC. Moreover, ZST93 induced suppressive autophagic flux and caspase-3-dependent cell death, which were further strengthened by the blocking of the autophagy process using chloroquine (CQ). Moreover, ZST93 enhanced CRC cells’ chemosensitivity to 5-FU via modulation of autophagy and apoptosis. Conclusion: ZST93 exerts anti-tumour effects via disruptive autophagic flux and apoptotic cell death in human CRC cells and increases cell chemosensitivity to 5-FU. These results provide insights into the utilisation of ZST93 as an adjuvant or direct autophagy inhibitor and suggest ZST93 as a novel therapeutic strategy for treating CRC.

scholarly journals The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells

2013 ◽  
Vol 7 (5) ◽  
pp. 1539-1544 ◽  
Author(s):  
YU-REN LIAO ◽  
CHI-CHENG LU ◽  
KUANG-CHI LAI ◽  
JAI-SING YANG ◽  
SHENG-CHU KUO ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
The Novel ◽  
Colorectal Cancer Cells

Soluble VEGF receptor 1(sFLT1) induces non-apoptotic cell death of ovarian and colorectal cancer cells

Placenta ◽  
2016 ◽  
Vol 46 ◽  
pp. 107
Author(s):  
Tatsuya Miyake ◽  
Keiichi Kumasawa ◽  
Noriko Sato ◽  
Tsuyoshi Takiuchi ◽  
Hitomi Nakamura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Vegf Receptor ◽  
Colorectal Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document