INGN 007, an oncolytic adenovirus vector, replicates in Syrian hamsters but not mice: comparison of biodistribution studies

B Ying; K Toth; J F Spencer; J Meyer; A E Tollefson; D Patra; D Dhar; E V Shashkova; M Kuppuswamy; K Doronin; M A Thomas; L A Zumstein; W S M Wold; D L Lichtenstein

doi:10.1038/cgt.2009.6

INGN 007, an oncolytic adenovirus vector, replicates in Syrian hamsters but not mice: comparison of biodistribution studies

Cancer Gene Therapy ◽

10.1038/cgt.2009.6 ◽

2009 ◽

Vol 16 (8) ◽

pp. 625-637 ◽

Cited By ~ 35

Author(s):

B Ying ◽

K Toth ◽

J F Spencer ◽

J Meyer ◽

A E Tollefson ◽

...

Keyword(s):

Adenovirus Vector ◽

Oncolytic Adenovirus ◽

Syrian Hamsters ◽

Biodistribution Studies

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651. VRX-007, an Oncolytic Adenovirus Vector, Replicates in Syrian Hamsters but Not Mice: Comparison of Biodistribution Studies Performed in the Syrian Hamster and Mouse

Molecular Therapy ◽

10.1016/j.ymthe.2006.08.727 ◽

2006 ◽

Vol 13 ◽

pp. S251

Author(s):

Drew L. Lichtenstein ◽

Karoly Toth ◽

Jaqueline F. Spencer ◽

Jenifer Meyer ◽

Baoling Ying ◽

...

Keyword(s):

Syrian Hamster ◽

Adenovirus Vector ◽

Oncolytic Adenovirus ◽

Syrian Hamsters ◽

Biodistribution Studies

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An acute toxicology study with INGN 007, an oncolytic adenovirus vector, in mice and permissive Syrian hamsters; comparisons with wild-type Ad5 and a replication-defective adenovirus vector

Cancer Gene Therapy ◽

10.1038/cgt.2009.5 ◽

2009 ◽

Vol 16 (8) ◽

pp. 644-654 ◽

Cited By ~ 30

Author(s):

D L Lichtenstein ◽

J F Spencer ◽

K Doronin ◽

D Patra ◽

J M Meyer ◽

...

Keyword(s):

Adenovirus Vector ◽

Oncolytic Adenovirus ◽

Wild Type ◽

Syrian Hamsters ◽

Toxicology Study ◽

Replication Defective Adenovirus

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1022. Single-Dose Intravenous Toxicity Study with the Oncolytic Adenovirus Vector VRX-007, Adenovirus Type 5, and a Replication-Defective Adenovirus in Syrian Hamsters

Molecular Therapy ◽

10.1016/j.ymthe.2005.07.569 ◽

2005 ◽

Vol 11 ◽

pp. S395

Keyword(s):

Single Dose ◽

Adenovirus Vector ◽

Adenovirus Type ◽

Oncolytic Adenovirus ◽

Toxicity Study ◽

Syrian Hamsters ◽

Adenovirus Type 5 ◽

Replication Defective Adenovirus

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642. Toxicological Findings with Oncolytic Adenovirus Vector VRX-007, Wild-Type Ad5, and a Replication-Defective Adenovirus Vector in Syrian Hamsters and C57BL/6 Mice

Molecular Therapy ◽

10.1016/j.ymthe.2006.08.718 ◽

2006 ◽

Vol 13 ◽

pp. S247

Author(s):

Karoly Toth ◽

Jacqueline F. Spencer ◽

Drew L. Lichtenstein ◽

Ann E. Tollefson ◽

Debabrata Patra ◽

...

Keyword(s):

Adenovirus Vector ◽

Oncolytic Adenovirus ◽

Wild Type ◽

Syrian Hamsters ◽

Replication Defective Adenovirus

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Cycles of transient high-dose cyclophosphamide administration and intratumoral oncolytic adenovirus vector injection for long-term tumor suppression in Syrian hamsters

Cancer Gene Therapy ◽

10.1038/cgt.2014.13 ◽

2014 ◽

Vol 21 (4) ◽

pp. 171-178 ◽

Cited By ~ 11

Author(s):

D Dhar ◽

K Toth ◽

W S M Wold

Keyword(s):

Tumor Suppression ◽

Adenovirus Vector ◽

Oncolytic Adenovirus ◽

High Dose ◽

Syrian Hamsters ◽

Cyclophosphamide Administration

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Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model

Molecular Therapy ◽

10.1038/mt.2009.156 ◽

2009 ◽

Vol 17 (10) ◽

pp. 1724-1732 ◽

Cited By ~ 23

Author(s):

Debanjan Dhar ◽

Jacqueline F Spencer ◽

Karoly Toth ◽

William SM Wold

Keyword(s):

Syrian Hamster ◽

Adenovirus Vector ◽

Oncolytic Adenovirus ◽

Passive Immunity ◽

Hamster Model ◽

Adenovirus 5

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Anticancer activity of oncolytic adenovirus vector armed with IFN-α and ADP is enhanced by pharmacologically controlled expression of TRAIL

Cancer Gene Therapy ◽

10.1038/sj.cgt.7701107 ◽

2007 ◽

Vol 15 (2) ◽

pp. 61-72 ◽

Cited By ~ 31

Author(s):

E V Shashkova ◽

M N Kuppuswamy ◽

W S M Wold ◽

K Doronin

Keyword(s):

Anticancer Activity ◽

Adenovirus Vector ◽

Oncolytic Adenovirus

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Treatment of Pancreatic Cancer With an Oncolytic Adenovirus Expressing Interleukin-12 in Syrian Hamsters

Molecular Therapy ◽

10.1038/mt.2009.9 ◽

2009 ◽

Vol 17 (4) ◽

pp. 614-622 ◽

Cited By ~ 57

Author(s):

Sergia Bortolanza ◽

Maria Bunuales ◽

Itziar Otano ◽

Gloria Gonzalez-Aseguinolaza ◽

Carlos Ortiz-de-Solorzano ◽

...

Keyword(s):

Pancreatic Cancer ◽

Oncolytic Adenovirus ◽

Interleukin 12 ◽

Syrian Hamsters

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9. Multiple Cycles of Transient Immunosuppression and Recovery with Multiple Rounds of Intratumoral Injection of an Oncolytic Adenovirus Vector: Tumor Efficacy Study in Permissive Syrian Hamster Model

Molecular Therapy ◽

10.1016/s1525-0016(16)38367-8 ◽

2009 ◽

Vol 17 ◽

pp. S4

Keyword(s):

Syrian Hamster ◽

Adenovirus Vector ◽

Intratumoral Injection ◽

Oncolytic Adenovirus ◽

Efficacy Study ◽

Hamster Model ◽

Multiple Cycles

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An Oncolytic Adenovirus Vector Combining Enhanced Cell-to-Cell Spreading, Mediated by the ADP Cytolytic Protein, with Selective Replication in Cancer Cells with Deregulated Wnt Signaling

Cancer Research ◽

10.1158/0008-5472.can-03-3882 ◽

2004 ◽

Vol 64 (10) ◽

pp. 3638-3644 ◽

Cited By ~ 39

Author(s):

Karoly Toth ◽

Hakim Djeha ◽

Baoling Ying ◽

Ann E. Tollefson ◽

Mohan Kuppuswamy ◽

...

Keyword(s):

Wnt Signaling ◽

Cancer Cells ◽

Adenovirus Vector ◽

Cell Spreading ◽

Oncolytic Adenovirus

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