scholarly journals A balance of Mad and Myc expression dictates larval cell apoptosis and adult stem cell development during Xenopus intestinal metamorphosis

2017 ◽  
Vol 8 (5) ◽  
pp. e2787-e2787 ◽  
Author(s):  
Morihiro Okada ◽  
Thomas C Miller ◽  
Luan Wen ◽  
Yun-Bo Shi
Keyword(s):  
Stem Cell ◽  
Cell Apoptosis ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Larval Cell

scholarly journals Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs

2020 ◽  
Vol 117 (7) ◽  
pp. 3603-3609 ◽  
Author(s):  
Fan Zou ◽  
Renjun Tu ◽  
Bo Duan ◽  
Zhenlin Yang ◽  
Zhaohua Ping ◽  
...  
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Germ Line ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Rna Modification ◽  
Proliferation And Differentiation ◽  
Germ Line Stem Cell ◽  
Rna Complex

5-Methylcytosine (m5C) is a RNA modification that exists in tRNAs and rRNAs and was recently found in mRNAs. Although it has been suggested to regulate diverse biological functions, whether m5C RNA modification influences adult stem cell development remains undetermined. In this study, we show that Ypsilon schachtel (YPS), a homolog of human Y box binding protein 1 (YBX1), promotes germ line stem cell (GSC) maintenance, proliferation, and differentiation in the Drosophila ovary by preferentially binding to m5C-containing RNAs. YPS is genetically demonstrated to function intrinsically for GSC maintenance, proliferation, and progeny differentiation in the Drosophila ovary, and human YBX1 can functionally replace YPS to support normal GSC development. Highly conserved cold-shock domains (CSDs) of YPS and YBX1 preferentially bind to m5C RNA in vitro. Moreover, YPS also preferentially binds to m5C-containing RNAs, including mRNAs, in germ cells. The crystal structure of the YBX1 CSD-RNA complex reveals that both hydrophobic stacking and hydrogen bonds are critical for m5C binding. Overexpression of RNA-binding–defective YPS and YBX1 proteins disrupts GSC development. Taken together, our findings show that m5C RNA modification plays an important role in adult stem cell development.

scholarly journals Essential Roles of Thyroid Hormone-Regulated Hyaluronan/CD44 Signaling in Adult Stem Cell Development During Xenopus laevis Intestinal Remodeling

Stem Cells ◽  
2017 ◽  
Vol 35 (10) ◽  
pp. 2175-2183 ◽  
Author(s):  
Takashi Hasebe ◽  
Kenta Fujimoto ◽  
Mitsuko Kajita ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Intestinal Remodeling

scholarly journals Expression Profiling of Intestinal Tissues Implicates Tissue-Specific Genes and Pathways Essential for Thyroid Hormone-Induced Adult Stem Cell Development

Endocrinology ◽  
2013 ◽  
Vol 154 (11) ◽  
pp. 4396-4407 ◽  
Author(s):  
Guihong Sun ◽  
Rachel A. Heimeier ◽  
Liezhen Fu ◽  
Takashi Hasebe ◽  
Biswajit Das ◽  
...  
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Expression Profiling ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Tissue Specific

Role of MAP kinases in nitric oxide induced muscle-derived adult stem cell apoptosis

2009 ◽  
Vol 33 (7) ◽  
pp. 711-719 ◽  
Author(s):  
D. Bironaite ◽  
D. Baltriukiene ◽  
N. Uralova ◽  
A. Stulpinas ◽  
V. Bukelskiene ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Stem Cell ◽  
Cell Apoptosis ◽  
Map Kinases ◽  
Adult Stem Cell
Sign in / Sign up

Export Citation Format

Share Document