scholarly journals Epithelial-Connective Tissue Interactions Induced by Thyroid Hormone Receptor Are Essential for Adult Stem Cell Development in the Xenopus laevis Intestine

Stem Cells ◽  
2011 ◽  
Vol 29 (1) ◽  
pp. 154-161 ◽  
Author(s):  
Takashi Hasebe ◽  
Daniel R. Buchholz ◽  
Yun-Bo Shi ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Connective Tissue ◽  
Xenopus Laevis ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Tissue Interactions

scholarly journals Essential Roles of Thyroid Hormone-Regulated Hyaluronan/CD44 Signaling in Adult Stem Cell Development During Xenopus laevis Intestinal Remodeling

Stem Cells ◽  
2017 ◽  
Vol 35 (10) ◽  
pp. 2175-2183 ◽  
Author(s):  
Takashi Hasebe ◽  
Kenta Fujimoto ◽  
Mitsuko Kajita ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Intestinal Remodeling

scholarly journals The thyroid hormone receptor gene (c-erbA alpha) is expressed in advance of thyroid gland maturation during the early embryonic development of Xenopus laevis.

1991 ◽  
Vol 11 (10) ◽  
pp. 5079-5089 ◽  
Author(s):  
D E Banker ◽  
J Bigler ◽  
R N Eisenman
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Xenopus Laevis ◽  
Hormone Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Thyroid Hormone Receptors ◽  
Stages Of Development ◽  
Xenopus Development

The c-erbA proto-oncogene encodes the thyroid hormone receptor, a ligand-dependent transcription factor which plays an important role in vertebrate growth and development. To define the role of the thyroid hormone receptor in developmental processes, we have begun studying c-erbA gene expression during the ontogeny of Xenopus laevis, an organism in which thyroid hormone has well-documented effects on morphogenesis. Using polymerase chain reactions (PCR) as a sensitive assay of specific gene expression, we found that polyadenylated erbA alpha RNA is present in Xenopus cells at early developmental stages, including the fertilized egg, blastula, gastrula, and neurula. By performing erbA alpha-specific PCR on reverse-transcribed RNAs from high-density sucrose gradient fractions prepared from early-stage embryos, we have demonstrated that these erbA transcripts are recruited to polysomes. Therefore, erbA is expressed in Xenopus development prior to the appearance of the thyroid gland anlage in tailbud-stage embryos. This implies that erbA alpha/thyroid hormone receptors may play ligand-independent roles during the early development of X. laevis. Quantitative PCR revealed a greater than 25-fold range in the steady-state levels of polyadenylated erbA alpha RNA across early stages of development, as expressed relative to equimolar amounts of total embryonic RNA. Substantial increases in the levels of erbA alpha RNA were noted at stages well after the onset of zygotic transcription at the mid-blastula transition, with accumulation of erbA alpha transcripts reaching a relative maximum in advance of metamorphosis. We also show that erbA alpha RNAs are expressed unequally across Xenopus neural tube embryos. This differential expression continues through later stages of development, including metamorphosis. This finding suggests that erbA alpha/thyroid hormone receptors may play roles in tissue-specific processes across all of Xenopus development.

scholarly journals Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development

2006 ◽  
Vol 25 (20) ◽  
pp. 4943-4951 ◽  
Author(s):  
Emmanuelle Havis ◽  
Sébastien Le Mevel ◽  
Ghislaine Morvan Dubois ◽  
De-Li Shi ◽  
Thomas S Scanlan ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Xenopus Laevis ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Eye Development
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