scholarly journals Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death

2015 ◽  
Vol 6 (4) ◽  
pp. e1731-e1731 ◽  
Author(s):  
K Kataoka ◽  
H Matsumoto ◽  
H Kaneko ◽  
S Notomi ◽  
K Takeuchi ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell ◽  
Inflammasome Activation

scholarly journals Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment

2014 ◽  
Vol 5 (5) ◽  
pp. e1269-e1269 ◽  
Author(s):  
H Matsumoto ◽  
Y Murakami ◽  
K Kataoka ◽  
H Lin ◽  
K M Connor ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell

scholarly journals Edaravone, an ROS Scavenger, Ameliorates Photoreceptor Cell Death after Experimental Retinal Detachment

2011 ◽  
Vol 52 (6) ◽  
pp. 3825 ◽  
Author(s):  
Mi In Roh ◽  
Yusuke Murakami ◽  
Aristomenis Thanos ◽  
Demetrios G. Vavvas ◽  
Joan W. Miller
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell ◽  
Ros Scavenger

scholarly journals Photoreceptor cell death and rescue in retinal detachment and degenerations

2013 ◽  
Vol 37 ◽  
pp. 114-140 ◽  
Author(s):  
Yusuke Murakami ◽  
Shoji Notomi ◽  
Toshio Hisatomi ◽  
Toru Nakazawa ◽  
Tatsuro Ishibashi ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell

scholarly journals NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

2016 ◽  
Vol 25 (8) ◽  
pp. 1501-1516 ◽  
Author(s):  
Ishaq A. Viringipurampeer ◽  
Andrew L. Metcalfe ◽  
Abu E. Bashar ◽  
Olena Sivak ◽  
Anat Yanai ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Degeneration ◽  
Nlrp3 Inflammasome ◽  
Photoreceptor Cell ◽  
Inflammasome Activation ◽  
Cone Photoreceptor ◽  
Nlrp3 Inflammasome Activation

scholarly journals Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

2018 ◽  
Vol 115 (27) ◽  
pp. E6264-E6273 ◽  
Author(s):  
Yoko Okunuki ◽  
Ryo Mukai ◽  
Elizabeth A. Pearsall ◽  
Garrett Klokman ◽  
Deeba Husain ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Immune Cells ◽  
Photoreceptor Cell ◽  
Immune Cell ◽  
Photoreceptor Layer ◽  
Activated Microglia ◽  
Retinal Microglia ◽  
Permanent Loss ◽  
And Function

Retinal detachment (RD) is a sight-threatening complication common in many highly prevalent retinal disorders. RD rapidly leads to photoreceptor cell death beginning within 12 h following detachment. In patients with sustained RD, progressive visual decline due to photoreceptor cell death is common, leading to significant and permanent loss of vision. Microglia are the resident immune cells of the central nervous system, including the retina, and function in the homeostatic maintenance of the neuro-retinal microenvironment. It is known that microglia become activated and change their morphology in retinal diseases. However, the function of activated microglia in RD is incompletely understood, in part because of the lack of microglia-specific markers. Here, using the newly identified microglia marker P2ry12 and microglial depletion strategies, we demonstrate that retinal microglia are rapidly activated in response to RD and migrate into the injured area within 24 h post-RD, where they closely associate with infiltrating macrophages, a population distinct from microglia. Once in the injured photoreceptor layer, activated microglia can be observed to contain autofluorescence within their cell bodies, suggesting they function to phagocytose injured or dying photoreceptors. Depletion of retinal microglia results in increased disease severity and inhibition of macrophage infiltration, suggesting that microglia are involved in regulating neuroinflammation in the retina. Our work identifies that microglia mediate photoreceptor survival in RD and suggests that this effect may be due to microglial regulation of immune cells and photoreceptor phagocytosis.

Müller Cell Reactivity and Photoreceptor Cell Death Are Reduced after Experimental Retinal Detachment Using an Inhibitor of the Akt/mTOR Pathway

2009 ◽  
Vol 50 (9) ◽  
pp. 4429 ◽  
Author(s):  
Geoffrey P. Lewis ◽  
Ethan A. Chapin ◽  
Jiyun Byun ◽  
Gabriel Luna ◽  
David Sherris ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell ◽  
Mtor Pathway ◽  
Cell Reactivity

scholarly journals Local photoreceptor cell death differences in the murine model of retinal detachment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniel E. Maidana ◽  
Lucia Gonzalez-Buendia ◽  
Joan W. Miller ◽  
Demetrios G. Vavvas
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Cell Count ◽  
Regional Differences ◽  
Photoreceptor Cell ◽  
Outer Nuclear Layer ◽  
Sodium Hyaluronate ◽  
Layer Cell ◽  
Local Cell ◽  
Subretinal Injection

AbstractTo investigate local cell death differences in the attached and detached retina at different regions in a murine experimental retinal detachment model. Subretinal injection of sodium hyaluronate was performed in eight-week-old C57BL/6J mice. Retinal regions of interest were defined in relation to their distance from the peak of the retinal detachment, as follows: (1) attached central; (2) attached paracentral; (3) detached apex; and (4) detached base. At day 0, the outer nuclear layer cell count for the attached central, attached paracentral, detached apex, and detached base was 1247.60 ± 64.62, 1157.80 ± 163.33, 1264.00 ± 150.7, and 1013.80 ± 67.16 cells, respectively. There were significant differences between the detached base vs. attached central, and between detached base vs. detached apex at day 0. The detached apex region displayed a significant and progressive cell count reduction from day 0 to 14. In contrast, the detached base region did not show progressive retinal degeneration in this model. Moreover, only the detached apex region had a significant and progressive cell death rate compared to baseline. Immediate confounding changes with dramatic differences in cell death rates are present across regions of the detached retina. We speculate that mechanical and regional differences in the bullous detached retina can modify the rate of cell death in this model.

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