scholarly journals An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesisin vivoand is a potential therapeutic target for human cancer

2010 ◽  
Vol 128 (5) ◽  
pp. 1018-1030 ◽  
Author(s):  
Di Wu ◽  
Kazuyuki Matsushita ◽  
Hisahiro Matsubara ◽  
Fumio Nomura ◽  
Takeshi Tomonaga
Keyword(s):  
Alternative Splicing ◽  
Therapeutic Target ◽  
Human Cancer ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Potential Therapeutic Target

scholarly journals Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer

2013 ◽  
Vol 9 (10) ◽  
pp. 1013-1020 ◽  
Author(s):  
Feng-wei Wang ◽  
Xin-yuan Guan ◽  
Dan Xie
Keyword(s):  
Human Cancer ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor

scholarly journals MicroRNA-34a: a potential therapeutic target in human cancer

2014 ◽  
Vol 5 (7) ◽  
pp. e1327-e1327 ◽  
Author(s):  
X J Li ◽  
Z J Ren ◽  
J H Tang
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Potential Therapeutic Target

scholarly journals Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Shinichiro Oku ◽  
Huijuan Feng ◽  
Steven Connor ◽  
Andrea Toledo ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Cell Surface ◽  
Splice Site ◽  
Therapeutic Target ◽  
Heparan Sulphate ◽  
Cortical Circuits ◽  
Potential Therapeutic Target ◽  
Brain Circuits ◽  
Presynaptic Differentiation ◽  
Positively Charged

Post-transcriptional mechanisms regulating cell surface synaptic organizing complexes that control the properties of connections in brain circuits are poorly understood. Alternative splicing regulates the prototypical synaptic organizing complex, neuroligin-neurexin. In contrast to the well-studied neuroligin splice site B, little is known about splice site A. We discovered that inclusion of the positively charged A1 insert in mouse neuroligin-1 increases its binding to heparan sulphate, a modification on neurexin. The A1 insert increases neurexin recruitment, presynaptic differentiation, and synaptic transmission mediated by neuroligin-1. We propose that the A1 insert could be a target for alleviating the consequences of deleterious NLGN1/3 mutations, supported by assays with the autism-linked neuroligin-1-P89L mutant. An enrichment of neuroligin-1 A1 in GABAergic neuron types suggests a role in synchrony of cortical circuits. Altogether, these data reveal an unusual mode by which neuroligin splicing controls synapse development through protein-glycan interaction and identify it as a potential therapeutic target.

Nrf2 is a potential therapeutic target in radioresistance in human cancer

2013 ◽  
Vol 88 (3) ◽  
pp. 706-715 ◽  
Author(s):  
Suna Zhou ◽  
Wenguang Ye ◽  
Qiuju Shao ◽  
Mingxin Zhang ◽  
Jun Liang
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Potential Therapeutic Target

scholarly journals SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer

2019 ◽  
Vol 9 ◽  
Author(s):  
Suraksha Tamang ◽  
Varnali Acharya ◽  
Deepronil Roy ◽  
Rinka Sharma ◽  
Apeksha Aryaa ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Human Cancer ◽  
Potential Therapeutic Target
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