scholarly journals Cancer-derived immunoglobulin G promotes tumor cell growth and proliferation through inducing production of reactive oxygen species

2013 ◽  
Vol 4 (12) ◽  
pp. e945-e945 ◽  
Author(s):  
J Wang ◽  
D Lin ◽  
H Peng ◽  
Y Huang ◽  
J Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Growth ◽  
Tumor Cell ◽  
Immunoglobulin G ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tumor Cell Growth ◽  
Cell Growth And Proliferation

Identification of the signature genes and network of Reactive Oxygen Species (ROS) related genes and DNA repair genes in Lung Adenocarcinoma (LUAD)

2021 ◽  
Author(s):  
Ye Zhao ◽  
Hai-Ming Feng ◽  
Xiao-Ping Wei ◽  
Wei-Jian Yan ◽  
Bin Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Repair ◽  
Tumor Cell ◽  
Lung Adenocarcinoma ◽  
Tumor Cells ◽  
Patient Survival ◽  
Reactive Oxygen ◽  
Dna Repair Genes ◽  
Oxygen Species ◽  
Repair Genes

Abstract Reactive Oxygen Species (ROS) are present in high amount in patients with tumors, and these ROS can kill and destroy tumor cells. Thus, tumor cells upregulate ROS-related genes to protect themselves and reduce their destruction. Cancer cells already damaged by ROS can be repaired by expressing DNA repair genes consequently promoting their proliferation. In this work, lung adenocarcinoma (LUAD) transcriptome data in the TCGA database was analyzed and samples were clustered into 5 ROS-related categories and 6 DNA repair categories. Survival analysis revealed a significant difference in patient survival between the two classification methods. In addition, the samples corresponding to the two categories overlap, thus, the gene expression profile of the same sample with different categories and survival prognosis was further explored, and the connection between ROS-related genes and DNA repair genes was investigated. The interactive sample recombination classification was used, revealing that the patient's prognosis was worse when the ROS-related genes and DNA repair genes were expressed at the same time. The further research on the potential regulatory network of the two categories of genes and the correlation analysis revealed that ROS-related genes and DNA repair genes have a mutual regulatory relationship. The ROS-related genes NQO1, TXNRD1, and PRDX4 could establish links with other DNA repair genes through the DNA repair gene NEIL3, thereby increasing the growth of tumor cells and balancing the level of ROS, leading to tumor cell death and constant damage to the tumor cell repair system, thus prolonging patient survival. Thus, targeting ROS-related genes and DNA repair genes might be a promising strategy in the treatment of LUAD. Finally, a survival prognostic model of ROS-related genes and DNA repair genes was established (TERT, PRKDC, PTTG1, SMUG1, TXNRD1, CAT, H2AFX and PFKP), the risk score might be used as an independent prognostic factor in LUAD patients.

Reactive oxygen species produced by NADPH oxidase regulate plant cell growth

Nature ◽  
2003 ◽  
Vol 422 (6930) ◽  
pp. 442-446 ◽  
Author(s):  
Julia Foreman ◽  
Vadim Demidchik ◽  
John H. F. Bothwell ◽  
Panagiota Mylona ◽  
Henk Miedema ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Growth ◽  
Nadph Oxidase ◽  
Plant Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Plant Cell Growth

Sea Buckthorn Leaf Extract Inhibits Glioma Cell Growth by Reducing Reactive Oxygen Species and Promoting Apoptosis

2017 ◽  
Vol 182 (4) ◽  
pp. 1663-1674 ◽  
Author(s):  
Sung-Jo Kim ◽  
Eunmi Hwang ◽  
Sun Shin Yi ◽  
Ki Duk Song ◽  
Hak-Kyo Lee ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Growth ◽  
Glioma Cell ◽  
Leaf Extract ◽  
Reactive Oxygen ◽  
Sea Buckthorn ◽  
Oxygen Species

scholarly journals Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma

Surgery ◽  
2015 ◽  
Vol 158 (3) ◽  
pp. 827-836 ◽  
Author(s):  
Yueming Zhu ◽  
Pritha Paul ◽  
Sora Lee ◽  
Brian T. Craig ◽  
Eric J. Rellinger ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Steady State ◽  
Cell Growth ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Anticancer effect of icaritin inhibits cell growth of colon cancer through reactive oxygen species, Bcl-2 and cyclin D1/E signaling

2016 ◽  
Vol 12 (5) ◽  
pp. 3537-3542 ◽  
Author(s):  
Chaofeng Li ◽  
Weichao Peng ◽  
Xin Song ◽  
Qian Wang ◽  
Wenyue Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Colon Cancer ◽  
Cell Growth ◽  
Cyclin D1 ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Anticancer Effect
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