scholarly journals Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice

2013 ◽  
Vol 20 (10) ◽  
pp. 1404-1414 ◽  
Author(s):  
P R Hiebert ◽  
D Wu ◽  
D J Granville
Keyword(s):  
Extracellular Matrix ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Wound Closure ◽  
Granzyme B ◽  
Apolipoprotein E Knockout Mice

Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice

2011 ◽  
Vol 46 (6) ◽  
pp. 489-499 ◽  
Author(s):  
Paul R. Hiebert ◽  
Wendy A. Boivin ◽  
Thomas Abraham ◽  
Sara Pazooki ◽  
Hongyan Zhao ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Granzyme B ◽  
Skin Aging ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Apolipoprotein E Knockout Mice

scholarly journals Perforin and Granzyme B Have Separate and Distinct Roles during Atherosclerotic Plaque Development in Apolipoprotein E Knockout Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e78939 ◽  
Author(s):  
Paul R. Hiebert ◽  
Wendy A. Boivin ◽  
Hongyan Zhao ◽  
Bruce M. McManus ◽  
David J. Granville
Keyword(s):  
Apolipoprotein E ◽  
Atherosclerotic Plaque ◽  
Knockout Mice ◽  
Granzyme B ◽  
Plaque Development ◽  
Apolipoprotein E Knockout Mice

scholarly journals Trans-10, cis-12- and cis-9, trans-11-Conjugated Linoleic Acid Isomers Selectively Modify HDL-Apolipoprotein Composition in Apolipoprotein E Knockout Mice

2006 ◽  
Vol 136 (2) ◽  
pp. 353-359 ◽  
Author(s):  
José M. Arbonés-Mainar ◽  
María A. Navarro ◽  
Sergio Acín ◽  
Mario A. Guzmán ◽  
Carmen Arnal ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Apolipoprotein E ◽  
Conjugated Linoleic Acid ◽  
Knockout Mice ◽  
Apolipoprotein E Knockout Mice

scholarly journals Monocyte chemoattractant protein-1 involvement in the α-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice

2003 ◽  
Vol 90 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Maria C. G. Peluzio ◽  
Emir Miguel ◽  
Thaís C. Drumond ◽  
Giovana C. César ◽  
Helton C. Santiago ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
Quantitative Polymerase Chain Reaction ◽  
Lesion Size ◽  
Tocopheryl Acetate ◽  
Aortic Lesion ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Apolipoprotein E Knockout Mice

We studied the effects of α-tocopheryl acetate supplementation on the development of fatty streaks and its ability to modulate the expression of monocyte chemoattractant protein (MCP)-1 in aortic lesions of apoliprotein E knockout mice. For this purpose, 16-week-old apolipoprotein E knockout mice received α-tocopherol supplemention ((800 mg)/kg diet) for 6 weeks. After this time, total and lipoprotein cholesterol in the serum, hepatic tocopherol, aortic lesion area and MCP-1 (protein and mRNA) expression were analysed. Our present results showed that the dietary supplementation with α-tocopherol did not reduce serum cholesterol nor change lipoprotein profile, but it reduced the area of the aortic lesion by 55%. The reduction in the lesion size was correlated with the reduced expression of MCP-1 mRNA and protein, as detected by real-time quantitative polymerase chain reaction and immunohistochemistry respectively. In conclusion, the results obtained here are relevant to the study of atherosclerosis, as they correlate the effectiveness of vitamin E supplementation in inhibiting the plaque formation with diminished expression of MCP-1 at the aortic lesion.

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