scholarly journals Healthy ageing twin study reveals role of genetic factors on BMD

2012 ◽  
Vol 1 (8) ◽  
Keyword(s):  
Twin Study ◽  
Genetic Factors ◽  
Healthy Ageing

scholarly journals The Role of Genetic Factors for Hearing Deterioration Across 20 Years: A Twin Study

2015 ◽  
Vol 70 (5) ◽  
pp. 647-653 ◽  
Author(s):  
Renata Bogo ◽  
Ahmed Farah ◽  
Ann-Christin Johnson ◽  
Kjell K. Karlsson ◽  
Nancy L. Pedersen ◽  
...  
Keyword(s):  
Twin Study ◽  
Genetic Factors

Role of Genetic Factors in Lower- and Higher-Order Aberrations – The Genes in Myopia Twin Study

2009 ◽  
Vol 41 (3) ◽  
pp. 142-147 ◽  
Author(s):  
M. Dirani ◽  
M. Chamberlain ◽  
T.A. Couper ◽  
R.H. Guymer ◽  
P.N. Baird
Keyword(s):  
Twin Study ◽  
Genetic Factors ◽  
Higher Order ◽  
Higher Order Aberrations

The Role of Genetic Factors in the Child Drawing Behavior - A Preliminary Twin Study

1976 ◽  
Vol 25 (1) ◽  
pp. 218-220
Author(s):  
Carla Candelori ◽  
Anna Oliverio Ferraris ◽  
Paolo Parisi
Keyword(s):  
Twin Study ◽  
Spatial Representation ◽  
Genetic Factors ◽  
Personality Development ◽  
Structural Factors ◽  
Pressure Area

A sample of 27 MZ and 32 DZ twin pairs, aged 6 to 12 years, has been tested with the Draw A Family Test. Significantly higher concordance values in MZ than DZ twins have been found with respect to some graphic-structural factors (i.e.: line, hand pressure, area of the drawing, dimensions of the figures, distribution, and shading) as well as with respect to contents factors, such as spatial representation and cotwin's valorization. These correlates of personality development would thus appear to undergo significant genetic conditioning.

scholarly journals The Role of Genetic Factors in the Child Drawing Behavior. A Preliminary Twin Study

1974 ◽  
Vol 23 (S2) ◽  
pp. 37-37
Author(s):  
C. Candelori ◽  
A. Oliverio-Ferraris ◽  
P. Parisi
Keyword(s):  
Twin Study ◽  
Genetic Factors

A Twin study of Individuals with both Schizophrenia and Alcoholism

1985 ◽  
Vol 147 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Kenneth S. Kendler
Keyword(s):  
Environmental Factors ◽  
Genetic Predisposition ◽  
Twin Study ◽  
Genetic Factors ◽  
Substantial Evidence

SummarySubstantial evidence suggests that genetic factors contribute to the aetiology of both schizophrenia and alcoholism, when they occur alone. To examine the role of genetic factors in schizophrenia and alcoholism when they occur together in the same individual, the frequency of both conditions was investigated in the co-twins of 34 monozygotic (MZ) and 47 dizygotic (DZ) index twins with a diagnosis of both schizophrenia and alcoholism. Both disorders alone were significantly more common in the MZ than in the DZ co-twins, suggesting that individuals suffering from schizophrenia and alcoholism have a genetic predisposition to both disorders, which is of the same nature as that which causes the two when they occur alone. In the co-twins of the MZ index twins, the diagnoses of schizophrenia and alcoholism were uncorrelated, indicating that the specific environmental factors of causal importance in the two disorders are not closely related.

Epigenetic factors and molecular markers of the risk of early pregnancy losses

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (3) ◽  
pp. 9-16
Author(s):  
Nataly I Frolova ◽  
Tatiana E Belokrinitskaya
Keyword(s):  
Early Pregnancy ◽  
Genetic Factors ◽  
Molecular Genetic ◽  
Pregnancy Complication ◽  
Common Complication ◽  
Epigenetic Factors ◽  
Genetic Determination ◽  
Periconceptional Period ◽  
Combined Impact

Background. Miscarriage is a common complication in early pregnancy. Current studies have shown a higher prevalence of miscarriage, ranging from 10 to 20%. The review is devoted to modern concepts of etiology and pathogenesis of early pregnancy losses. Aim. Assess the role of epigenetic factors and molecular-genetic markers in the pathogenesis and prediction of early pregnancy losses Materials and methods. In order to write this review domestic and foreign publications were searched in Russian and international search systems (PubMed, eLibrary, etc.) for the last 10-15 years. Relevant articles from the peer-reviewed literature and clinical practice guidelines were included. Results. Many recent studies have proved the contribution of various epigenetic factors to the pathogenesis of spontaneous miscarriages, and the molecular-genetic determination such kinds of pregnancy complication has been confirmed. Conclusion. The miscarriage in early gestation is driven by combined impact of epigenetic and molecular-genetic factors, as well as the presence of intergenic interactions. It is may lead to deterioration of physiological functions, and maternal pathologenic pathways could be changed as during her periconceptional period as so during the pregnancy.

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

The Role of Negative Personality Traits in Psychological Adaptation

2019 ◽  
pp. 115-125
Author(s):  
Юлия Черткова ◽  
Yuliya Chertkova ◽  
Марина Егорова ◽  
Marina Yegorova
Keyword(s):  
Life Satisfaction ◽  
Personality Traits ◽  
Twin Study ◽  
Monozygotic Twins ◽  
Psychological Adaptation ◽  
Semantic Differential ◽  
Personal Traits ◽  
Only Children ◽  
Age Related

The paper reflects one of the aspects of the research carried out within the framework of the project “Nature of variability of negative personality traits: a twin study”. The research reviews the adaptive component of negative personal traits. The sample of the study consisted of 136 members of monozygotic twins and 401 only children in their families aged 18-78. Life satisfaction was a generalized metric of psychological adaptation. It is shown that a number of negative personality traits (in particular, narcissism, authoritarianism) positively correlate with life satisfaction. The biased value of various personality traits, which can also indirectly serve as an indicator of adaptability of these psychological properties, was assessed using a semantic differential. The age-related changes in the perfect image of the self, which are associated primarily with some more attractive negative personal traits, as well as the multidirectional desired changes in personality traits in themselves and the twin (more power and conflict in themselves and less of the same in the brother/sister) also indicate that a number of negative personal traits play a positive role in psychological adaptation. It is assumed that these traits can have a compensatory function during stress, and the destructiveness of these traits can have a greater impact on people around than on themselves.

scholarly journals Genetic Determinants of Paget’s Disease of Bone

2021 ◽  
Author(s):  
Navnit S. Makaram ◽  
Stuart H. Ralston
Keyword(s):  
Genetic Factors ◽  
Association Studies ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Genome Wide Association Studies ◽  
Paget's Disease Of Bone ◽  
Genome Wide ◽  
Family Based

Abstract Purpose of Review To provide an overview of the role of genes and loci that predispose to Paget’s disease of bone and related disorders. Recent Findings Studies over the past ten years have seen major advances in knowledge on the role of genetic factors in Paget’s disease of bone (PDB). Genome wide association studies have identified six loci that predispose to the disease whereas family based studies have identified a further eight genes that cause PDB. This brings the total number of genes and loci implicated in PDB to fourteen. Emerging evidence has shown that a number of these genes also predispose to multisystem proteinopathy syndromes where PDB is accompanied by neurodegeneration and myopathy due to the accumulation of abnormal protein aggregates, emphasising the importance of defects in autophagy in the pathogenesis of PDB. Summary Genetic factors play a key role in the pathogenesis of PDB and the studies in this area have identified several genes previously not suspected to play a role in bone metabolism. Genetic testing coupled to targeted therapeutic intervention is being explored as a way of halting disease progression and improving outcome before irreversible skeletal damage has occurred.

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