scholarly journals Effects of an outpatient physical exercise program on hematopoietic stem-cell transplantation recipients: a randomized clinical trial

2010 ◽  
Vol 46 (9) ◽  
pp. 1245-1255 ◽  
Author(s):  
R H Knols ◽  
E D de Bruin ◽  
D Uebelhart ◽  
G Aufdemkampe ◽  
U Schanz ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Physical Exercise ◽  
Stem Cell Transplantation ◽  
Randomized Clinical Trial ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Exercise Program ◽  
Hematopoietic Stem

scholarly journals Influence of a Moderate-Intensity Exercise Program on Early NK Cell Immune Recovery in Pediatric Patients After Reduced-Intensity Hematopoietic Stem Cell Transplantation

2016 ◽  
Vol 16 (4) ◽  
pp. 464-472 ◽  
Author(s):  
Carolina Chamorro-Viña ◽  
Jaime Valentín ◽  
Lucía Fernández ◽  
Marta González-Vicent ◽  
Margarita Pérez-Ruiz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Nk Cell ◽  
Exercise Program ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Hematopoietic Stem

Introduction: After allogeneic hematopoietic stem cell transplantation (HSCT), NK cell reconstitution, which is crucial for positive outcomes, is dominated by the CD56bright subset with low NK cell cytotoxicity (NKCC) activity. Moderate exercise has been described as a potent NK cell stimulus in adults with cancer. Purpose: To determine the effects of a moderate-intensity exercise program on NK cell recovery early after HSCT and the feasibility of this intervention. Methods: Six children undergoing allogeneic HSCT were randomized to an exercise program (EP) or control (CT) group. The EP group performed a 10-week training combining in-hospital and home-based EP. Results: We observed a significant increase in the posttraining/pretraining ratio of the CD56dim subset (EP = 1.27 ± 0.07; CT = 0.99 ± 0.08; P < .005) of the EP group. The ratio of NKCC was 8 times greater in the EP group. Conclusion: Data suggest that a moderate-intensity EP program performed early after HSCT is feasible and might redistribute the CD56dim/CD56brigh NK cell subset, improving NKCC. The results are still preliminary and must be interpreted with caution.

Autologous hematopoietic stem cell transplantation for Stiff Person Spectrum Disorder: A clinical trial

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011338
Author(s):  
Richard K Burt ◽  
Roumen Balabanov ◽  
Xiaoqiang Han ◽  
Kathleen Quigley ◽  
Indira Arnautovic ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Spectrum Disorder ◽  
Hematopoietic Stem ◽  
Link Type ◽  
Normal Tendon

Objective:To test the hypothesis that autologous non-myeloablative hematopoietic stem cell transplantation (HSCT) is safe and shows efficacy in the treatment of stiff person spectrum disorder (SPSD).Methods:Twenty-three participants were treated in a prospective open-label cohort study of safety and efficacy. Following stem cell mobilization with cyclophosphamide (2 g/m2) and filgrastim (5–-10 ug/kg/day), participants were treated with cyclophosphamide (200 mg/kg) divided as 50 mg/kg IV on day −-5 to day −-2, rATG (thymoglobulin) given IV at 0.5 mg/kg on day −-5, 1 mg/kg on day −-4 and −-3, and 1.5 mg/kg on days −-2, and −-1 (total dose 5.5 mg/kg), and rituximab 500 mg IV on days −-6 and +1. Unselected peripheral blood stem cells were infused on day 0. Safety was assessed by survival and NCI common toxicity criteria for adverse events during HSCT. Outcome was assessed by ≥ 50% decrease or discontinuation of anti-spasmodic drugs and by quality of life instruments.Results:There was no treatment-related mortality. One participant died 1 year after transplant from disease progression. 74% of participants responded, 47% have stayed in remission for a mean of 3.5 years, and 26% did not respond. When compared to non-responders, responders were more likely to have pre-transplant intermittent muscle spasms (16/17 vsversus 0/6), normal reflexes (12/17 vsversus 0/6) and positive cerebrospinal fluid anti-GAD serology (12/14 vsversus 2/6). Compared to responders, non-responders were more likely to have lead pipe rigidity (4/6 vsversus 0/17), and EMG documented simultaneous contraction of agonist / antagonist limb muscles (4/6 vsversus 1/17). Pre-HSCT use of prescription SSRI and or SNRI was more common in those who relapsed or never responded (9/12) compared to those responders who never relapsed (0/11).Conclusion:In this cohort, HSCT was safe, but beneficial effect of HSCT was variable and predominately confined to participants with episodic spasms, normal tendon reflexes, without simultaneous co-contraction of limb agonist antagonist muscles, and who were not taking SSRI or SNRI antidepressants.Classification of eEvidence:This study provides Class IV evidence that for a subset of people with SPSD, autologous non-myeloablative HSCT improves outcomes.Clinical trial registry:ClinicalTrials.gov Identifier: NCT02282514.

scholarly journals Bleeding frequency during physiotherapy in thrombocytopenic patients undergoing hematopoietic stem cell transplantation

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0255413
Author(s):  
Erick Alvaro Grencheski ◽  
Margarete Noriko Kochi ◽  
Flávia Vanessa Aurea Politi ◽  
Tabata Maruyama dos Santos ◽  
Christina May Moran de Brito ◽  
...  
Keyword(s):  
Stem Cell ◽  
Platelet Count ◽  
Hematopoietic Stem Cell Transplantation ◽  
Physical Exercise ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Moderate Intensity ◽  
Bleeding Events ◽  
Hematopoietic Stem

Background During hematopoietic stem cell transplantation (HSCT) the patients perform activities of low and moderate intensity because have reduced hematological lineages, leaving them susceptible to hemorrhagic events. The objective of this study was to describe the frequency of bleeding events, severity, and possible association with physical exercise in thrombocytopenic patients. Methods A retrospective study with seventy-seven HSCT patients hospitalised, that had a platelet count ≤ 50,000 /μL and received physical exercise during physiotherapy intervention. Results Regarding bleeding events, only six were related to physical exercise, and bleeding events occurred more frequently at platelet levels ≤ 10,000 /μL. The most frequent bleeding event was epistaxis, considered of low severity, and with the moderate possibility of being related to physical exercise; followed by extremity hematoma, considered of medium severity and highly related to physical exercise. In this study, there was no occurrence of bleeding events considered of high severity. Conclusion Bleeding frequency in supervised physical exercise during physiotherapy in adults with thrombocytopenia undergoing HSCT is minor and relatively rare but occurs more frequently in patients with platelet count ≤10,000 /μL. These results encourage the maintenance of physical activity in this population who is at high risk of developing immobility-related complications.

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