Investigation of the Effects of an Exercise Program on Physical Functions and Activities of Daily Life in Pediatric Hematopoietic Stem Cell Transplantation

2016 ◽  
Vol 63 (9) ◽  
pp. 1643-1648 ◽  
Author(s):  
Vesile Yildiz Kabak ◽  
Tulin Duger ◽  
Duygu Uckan Cetinkaya
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Daily Life ◽  
Exercise Program ◽  
Hematopoietic Stem ◽  
Activities Of Daily Life ◽  
Physical Functions

scholarly journals Influence of a Moderate-Intensity Exercise Program on Early NK Cell Immune Recovery in Pediatric Patients After Reduced-Intensity Hematopoietic Stem Cell Transplantation

2016 ◽  
Vol 16 (4) ◽  
pp. 464-472 ◽  
Author(s):  
Carolina Chamorro-Viña ◽  
Jaime Valentín ◽  
Lucía Fernández ◽  
Marta González-Vicent ◽  
Margarita Pérez-Ruiz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Nk Cell ◽  
Exercise Program ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Hematopoietic Stem

Introduction: After allogeneic hematopoietic stem cell transplantation (HSCT), NK cell reconstitution, which is crucial for positive outcomes, is dominated by the CD56bright subset with low NK cell cytotoxicity (NKCC) activity. Moderate exercise has been described as a potent NK cell stimulus in adults with cancer. Purpose: To determine the effects of a moderate-intensity exercise program on NK cell recovery early after HSCT and the feasibility of this intervention. Methods: Six children undergoing allogeneic HSCT were randomized to an exercise program (EP) or control (CT) group. The EP group performed a 10-week training combining in-hospital and home-based EP. Results: We observed a significant increase in the posttraining/pretraining ratio of the CD56dim subset (EP = 1.27 ± 0.07; CT = 0.99 ± 0.08; P < .005) of the EP group. The ratio of NKCC was 8 times greater in the EP group. Conclusion: Data suggest that a moderate-intensity EP program performed early after HSCT is feasible and might redistribute the CD56dim/CD56brigh NK cell subset, improving NKCC. The results are still preliminary and must be interpreted with caution.

scholarly journals Development of an Evidence-Based Exercise Program for Patients Undergoing Hematopoietic Stem Cell Transplantation

2021 ◽  
Author(s):  
Ki-Yong An ◽  
Mi-Seong Yu ◽  
Wonhee Cho ◽  
Meeok Choi ◽  
Kerry Courneya ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Group Discussion ◽  
Exercise Program ◽  
Evidence Based ◽  
Expert Group ◽  
Hematopoietic Stem

Abstract PURPOSE Although the efficacy of different exercise programs on different outcomes of hematopoietic stem cell transplantation (HSCT) patients have been examined, the details of process of exercise program development has not been described previously. In this study, we described the systematic development process of an evidence-based exercise program for HSCT patients. METHODS We developed the exercise program for HSCT patients using eight steps: (1) a literature review, (2) understanding patient characteristics, (3) first expert group discussion, (4) development of the first draft of the exercise program, (5) a pre-test, (6) second expert group discussion, (7) a pilot study, and (8) a focus group interview. RESULTS Through six systematic steps, tailored exercise program was developed based on patients’ physical and hospital room conditions, which varies in intensity (three different intensities) and exercise positions (supine, sitting, and standing). Then, a pilot randomized trial was conducted on 21 patients with HSCT patients. The adherence rate to exercise program was 44.7% and significantly better timed up and go and symptom scale were seen in the exercise group compared than those of control group. Through the last step, three barriers and four facilitators of exercise during HSCT were identified. CONCLUSION A safe and feasible tailored unsupervised exercise program for patients during HSCT was developed and tested. In the future, the efficacy of the exercise program should be tested with RCT with implementation strategies to reduce exercise barriers and maximize facilitators of exercise identified in the current study.

Caregiver perspectives on psychosocial care in pediatric hematopoietic stem cell transplantation (HCT).

2020 ◽  
Vol 8 (1) ◽  
pp. 67-78 ◽  
Author(s):  
Anne E. Kazak ◽  
Avi Madan Swain ◽  
Ahna L. H. Pai ◽  
Kimberly Canter ◽  
Olivia Carlson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Psychosocial Care ◽  
Hematopoietic Stem
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