scholarly journals Favourable prognostic role of histological regression in stage III positive sentinel lymph node melanoma patients

2017 ◽  
Vol 118 (3) ◽  
pp. 398-404 ◽  
Author(s):  
D Zugna ◽  
R Senetta ◽  
S Osella-Abate ◽  
M T Fierro ◽  
A Pisacane ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Positive Sentinel Lymph Node ◽  
Stage Iii ◽  
Prognostic Role ◽  
Melanoma Patients ◽  
Histological Regression

The prognostic role of metastatic lymph node immunological status in clinical stage III melanoma patients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e20103-e20103
Author(s):  
Piotr Rutkowski ◽  
Aleksandra Gos ◽  
Joost van den Oord ◽  
Monika Jurkowska ◽  
Katarzyna Szamotulska ◽  
...  
Keyword(s):  
Lymph Node ◽  
Metastatic Lymph Node ◽  
Clinical Stage ◽  
Stage Iii ◽  
Prognostic Role ◽  
Immunological Status ◽  
Metastatic Lymph ◽  
Melanoma Patients ◽  
Stage Iii Melanoma

scholarly journals Prognostic Role of Non-Identification of Sentinel Lymph Node in Cutaneous Melanoma Patients: An Observational Retrospective Study

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3151
Author(s):  
Ruggero Moro ◽  
Cintia Arjona-Aguilera ◽  
Celia Requena ◽  
Virginia Pont-Sanjuan ◽  
Victor Traves ◽  
...  
Keyword(s):  
Lymph Node ◽  
Retrospective Study ◽  
Sentinel Lymph Node ◽  
Cutaneous Melanoma ◽  
Disease Free Survival ◽  
Prognostic Role ◽  
Free Survival ◽  
Melanoma Patients

Background: Sentinel lymph node (SLN) status is recognized as the most important prognostic factor for patients with cutaneous melanoma. However, sometimes it is not possible to identify SLN. The phenomenon of non-identification of SLN and its prognostic role have not been thoroughly evaluated in melanoma literature. The objective of this study was to identify which patient or tumor variables may be associated to non-identification of SLN and to evaluate the prognostic role of non-identification of SLN. Methods: Observational retrospective study of 834 cutaneous melanoma patients who underwent SLN biopsy at Instituto Valenciano de Oncología. Results: Forty-two patients (5%) presented non-identification of SLN. Patients with age at diagnosis of ≥ 64 years, obesity (BMI ≥ 30), and head and neck localization were at higher risk of non-identification of SLN. Non-identified SLN patients had worse nodal disease-free survival with respect to negative SLN patients, but not worse melanoma-specific survival. Conclusions: Our findings suggest a need to follow-up patients with non-identified SLN in the same way as patients with positive SLN.

Prognostic Role of Multiple Lymphatic Basin Drainage in Sentinel Lymph Node-Negative Trunk Melanoma Patients: A Multicenter Study from the Italian Melanoma Intergroup

2015 ◽  
Vol 23 (5) ◽  
pp. 1708-1715 ◽  
Author(s):  
Simone Ribero ◽  
Simona Osella-Abate ◽  
Sandro Pasquali ◽  
Carlo Riccardo Rossi ◽  
Lorenzo Borgognoni ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Multicenter Study ◽  
Prognostic Role ◽  
Node Negative ◽  
Melanoma Patients

Early Recurrence in Sentinel Lymph Node Positive Stage III Melanoma Patients

2012 ◽  
Vol 78 (7) ◽  
pp. 808-813
Author(s):  
Justin J. Baker ◽  
David W. Ollila ◽  
Allison M. Deal ◽  
Jill Frank ◽  
Keith D. Amos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Risk Score ◽  
Recurrence Risk ◽  
Early Recurrence ◽  
Stage Iii ◽  
Melanoma Patients ◽  
Stage Iii Melanoma

Patients with sentinel lymph node (SLN) positive melanoma have a significant recurrence risk. We sought to examine variables associated with development of early recurrence. A prospective institutional review board-approved database of cutaneous melanoma patients treated from 2003 to 2010 was used to identify SLN positive stage III patients with 1 year of follow-up. The Kaplan-Meier method, and logistic regression were used to evaluate variables associated with early recurrence. Seventy-four patients were identified. Twenty-four (32%) had an early recurrence. Five variables were highly significantly associated with early recurrence: location of head/neck, Breslow depth greater than two, ulceration, number of lymph nodes positive ≥ 2, and largest lymph node metastasis >1 mm. Using these five variables, a numerical risk score was created from 0 to 5 to determine if an early recurrence occurred as the number of risk factors increased. The proportion of patients with early recurrence increased in linear fashion with increasing risk score ( P < 0.0001). These data suggest that SLN positive stage III melanoma patients have a significant risk of early recurrence, which is associated with several defined variables and increases with the number of risk factors present. These data may be useful in stratifying patients to level of recurrence risk and adjusting follow-up schedules.

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