scholarly journals Prognostic role of sentinel lymph node biopsy for patients with cutaneous melanoma: A retrospective study of surveillance, epidemiology, and end-result population-based data

Oncotarget ◽  
2016 ◽  
Vol 7 (29) ◽  
pp. 45671-45677 ◽  
Author(s):  
Jie Chen ◽  
Yu Xu ◽  
Ye Zhou ◽  
Yanong Wang ◽  
Huiyan Zhu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Retrospective Study ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cutaneous Melanoma ◽  
Population Based ◽  
Lymph Node Biopsy ◽  
Prognostic Role ◽  
Node Biopsy

Clinical Relevance of Sentinel Lymph Node Status Examined with Conventional Histology and Molecular Biology

2009 ◽  
Vol 95 (3) ◽  
pp. 298-302 ◽  
Author(s):  
Rocco Micciolo ◽  
Sebastiana Boi ◽  
Loredana Paoli ◽  
Paolo Cristofolini ◽  
Salvatore Girlando ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Molecular Biology ◽  
Cutaneous Melanoma ◽  
Lymph Node Biopsy ◽  
Lymph Node Status ◽  
Node Biopsy ◽  
Conventional Histology

Aims and background The presence of nodal metastases in patients with primary cutaneous melanoma adversely affects the biological behavior and is related to a poor prognosis. The role of sentinel lymph node biopsy is still debated. The aim of this study was to evaluate the prognostic role of sentinel lymph node biopsy with respect to disease-free period and overall survival. Patients and methods Patients with invasive cutaneous melanoma who underwent sentinel lymph node biopsy in the Santa Chiara Hospital of Trento between October 1997 and December 2002 were evaluated. The lymph nodes were examined with conventional histology, S100 and tyrosinase in immunohistochemistry, and tyrosinase in molecular biology. Results There were 144 patients with 198 sentinel lymph nodes. A significant association was found in conventional histology with Clark level and Breslow thickness. The prognostic role of sentinel lymph node status was independent of the other considered variables. However, no significant association was found with the molecular biology test. A significant excess of positive results at molecular biology was found. Conclusions Sentinel lymph node biopsy is an important independent prognostic factor for invasive cutaneous melanoma, but only when evaluated with conventional histology. As a result of this study, we stopped performing the tyrosinase test in molecular biology.

scholarly journals Sentinel Lymph Node Biopsy in Patients with Thick Primary Cutaneous Melanoma: Patterns of Use and Underuse Utilizing a Population-Based Model

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Steve R. Martinez ◽  
Dhruvil R. Shah ◽  
Anthony D. Yang ◽  
Robert J. Canter ◽  
Emanual Maverakis
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cutaneous Melanoma ◽  
Population Based ◽  
Lymph Node Biopsy ◽  
National Guidelines ◽  
Primary Cutaneous Melanoma ◽  
Logistic Regression Models ◽  
Node Biopsy

Background. Sentinel lymph node biopsy (SLNB) for thick cutaneous melanoma is supported by national guidelines. We report on factors associated with the use and underuse of SLNB for thick primary cutaneous melanoma. Methods. The Surveillance, Epidemiology, and End Results database was queried for patients who underwent surgery for thick primary cutaneous melanoma from 2004 to 2008. We used multivariate logistic regression models to predict use of SLNB. Results. Among 1,981 patients, 833 (41.8%) did not undergo SLNB. Patients with primary melanomas of the arm (OR 2.07, CI 1.56–2.75; P<0.001), leg (OR 2.40, CI 1.70–3.40; P<0.001), and trunk (OR 1.82, CI 1.38–2.40; P<0.001) had an increased likelihood of receiving a SLNB, as did those with desmoplastic histology (OR 1.47, CI 1.11–1.96; P=0.008). A decreased likelihood of receiving SLNB was noted for advancing age ≥ 60 years (age 60 to 69: OR 0.58, CI 0.33–0.99, P=0.047; age 70 to 79: OR 0.32, CI 0.19–0.54, P<0.001; age 80 or more: OR 0.10, CI 0.06–0.16, P<0.001) and unknown race/ethnicity (OR 0.21, CI 0.07–0.62; P=0.005). Conclusions. In particular, elderly patients are less likely to receive SLNB. Further research is needed to assess whether use of SLNB in this population is detrimental or beneficial.

Sign in / Sign up

Export Citation Format

Share Document