scholarly journals The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study

2017 ◽  
Vol 117 (9) ◽  
pp. 1405-1411 ◽  
Author(s):  
Xiaoshuang Feng ◽  
Gang Wang ◽  
Ni Li ◽  
Zhangyan Lyu ◽  
Shuohua Chen ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Liver Cancer ◽  
Prospective Study ◽  
Primary Liver Cancer ◽  
Fasting Blood Glucose ◽  
Population Based

scholarly journals Fasting Blood Glucose, Cholesterol, and Risk of Primary Liver Cancer: The Kailuan Study

2021 ◽  
Author(s):  
Xiangming Ma ◽  
Haozhe Cui ◽  
Miaomiao Sun ◽  
Qian Liu ◽  
Xining Liu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Fasting Blood Glucose

263 The incidence of primary liver cancer in Denmark: A 25-year population-based study

2006 ◽  
Vol 44 ◽  
pp. S104
Author(s):  
P. Jepsen ◽  
H. Vilstrup ◽  
S. Friis ◽  
H.T. Sørensen
Keyword(s):  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Population Based ◽  
Population Based Study

scholarly journals Relationship Between Fish Oil Use and Incidence of Primary Liver Cancer: Findings From a Population-Based Prospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Wei Jiang ◽  
Fu-Rong Li ◽  
Huan-Huan Yang ◽  
Guo-Chong Chen ◽  
Yong-Fei Hua
Keyword(s):  
Liver Cancer ◽  
Fish Oil ◽  
Lower Risk ◽  
Proportional Hazards ◽  
Dietary Habits ◽  
Primary Liver Cancer ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Histological Subtypes ◽  
Cox Proportional Hazards Models

Background: N-3 long-chain polyunsaturated fatty acids (LCPUFAs) prevented non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in studies of mouse models. We examined prospective relationships between fish oil use and risk of primary liver cancer and the major histological subtypes, such as HCC and intrahepatic cholangiocarcinoma (ICC).Methods: We included 434,584 middle-aged and older men and women who were free of cancer at recruitment of the UK Biobank (2006–2010). Information on fish oil use and other dietary habits was collected via questionnaires. Cox proportional hazards models were used to compute the hazard ratio (HR) and 95% CI of liver cancer associated with fish oil use, with adjustment for socio-demographic, lifestyle, dietary, and other clinical risk factors.Results: At baseline, 31.4% of participants reported regular use of fish oil supplements. During a median of 7.8 years of follow-up, 262 incident liver cancer cases were identified, among which 127 were HCC and 110 were ICC cases. As compared with non-users, fish oil users had a significantly 44% (95% CI: 25–59%) lower risk of total liver cancer, and 52% (95% CI: 24–70%) and 40% (95% CI: 7–61%) lower risk of HCC and ICC, respectively. Higher intake of oily fish also was associated with a lower risk of HCC (≥2 vs. <1 serving/week: HR = 0.46; 95% CI: 0.23–0.96; P-trend = 0.027) but not ICC (P-trend = 0.96).Conclusion: Habitual use of fish oil supplements was associated lower risk of primary liver cancer regardless of cancer histological subtypes, potentially supporting a beneficial role of dietary n-3 LCPUFAs in liver cancer prevention.

scholarly journals Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis

Rheumatology ◽  
2020 ◽  
Vol 59 (11) ◽  
pp. 3229-3236 ◽  
Author(s):  
Karin Wadström ◽  
Lennart Jacobsson ◽  
Aladdin J Mohammad ◽  
Kenneth J Warrington ◽  
Eric L Matteson ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Medical Records ◽  
Case Control Study ◽  
Fasting Blood Glucose ◽  
Population Based ◽  
Case Control ◽  
Current Smoking ◽  
Nested Case Control ◽  
Baseline Screening ◽  
Control Study

Abstract Objectives To investigate metabolic features that may predispose to GCA in a nested case–control study. Methods Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N = 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Results A total of 76 cases with a confirmed incident diagnosis of GCA (61% female, 65% biopsy positive, mean age at diagnosis 70 years) were identified. The median time from screening to diagnosis was 20.7 years (range 3.0–32.1). Cases had significantly lower fasting blood glucose (FBG) at baseline screening compared with controls [mean 4.7 vs 5.1 mmol/l (S.d. overall 1.5), odds ratio (OR) 0.35 per mmol/l (95% CI 0.17, 0.71)] and the association remained significant when adjusted for smoking [OR 0.33 per mmol/l (95% CI 0.16, 0.68)]. Current smokers had a reduced risk of GCA [OR 0.35 (95% CI 0.18, 0.70)]. Both cholesterol [mean 5.6 vs 6.0 mmol/l (S.d. overall 1.0)] and triglyceride levels [median 1.0 vs 1.2 mmol/l (S.d. overall 0.8)] were lower among the cases at baseline screening, with significant negative associations with subsequent GCA in crude and smoking-adjusted models [OR 0.62 per mmol/l (95% CI 0.43, 0.90) for cholesterol; 0.46 per mmol/l (95% CI 0.27, 0.81) for triglycerides]. Conclusion Development of GCA was associated with lower FBG and lower cholesterol and triglyceride levels at baseline, all adjusted for current smoking, suggesting that metabolic features predispose to GCA.

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