Paraneoplastic thrombocytosis is associated with increased mortality and increased rate of lymph node metastasis in oesophageal adenocarcinoma

Pathology ◽  
2017 ◽  
Vol 49 (5) ◽  
pp. 471-475 ◽  
Author(s):  
Agoston T. Agoston ◽  
Amitabh Srivastava ◽  
Yifan Zheng ◽  
Raphael Bueno ◽  
Robert D. Odze ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oesophageal Adenocarcinoma ◽  
Node Metastasis

scholarly journals Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro

2015 ◽  
Vol 113 (5) ◽  
pp. 738-746 ◽  
Author(s):  
Wenqing Cao ◽  
Jeffrey H Peters ◽  
Dylan Nieman ◽  
Meenal Sharma ◽  
Thomas Watson ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Oesophageal Adenocarcinoma ◽  
Cancer Cell Invasion ◽  
Node Metastasis

scholarly journals Endoscopic resection of Barrett’s adenocarcinoma: Intramucosal and low-risk tumours are not associated with lymph node metastases

2020 ◽  
pp. 205064062095890
Author(s):  
Nicolas Benech ◽  
Marc O’Brien ◽  
Maximilien Barret ◽  
Jérémie Jacques ◽  
Gabriel Rahmi ◽  
...  
Keyword(s):  
Lymph Node ◽  
High Risk ◽  
Lymph Node Metastasis ◽  
Endoscopic Resection ◽  
Low Risk ◽  
Oesophageal Adenocarcinoma ◽  
Depth Of Invasion ◽  
Histological Features ◽  
Node Metastasis

Background Superficial oesophageal adenocarcinoma can be resected endoscopically, but data to define a curative endoscopic resection are scarce. Objective Our study aimed to assess the risk of lymph node metastasis depending on the depth of invasion and histological features of oesophageal adenocarcinoma. Methods We retrospectively included all patients undergoing an endoscopic resection for T1 oesophageal adenocarcinoma among seven expert centres in France in 2004–2016. Mural invasion was defined as either intramucosal or submucosal tumours; the latter were further divided into superficial submucosal (≤1000 µm) and deep submucosal (>1000 µm). Absence or presence of lymphovascular invasion and/or poorly differentiated cancer (G3) defined a low-risk or a high-risk tumour, respectively. For submucosal tumours, invasion depth and histological features were systematically confirmed after a second dedicated histological assessment (new 2-mm thick slices) performed by a second pathologist. Occurrence of lymph node metastasis was recorded during the follow-up from histological or PET CT reports when an invasive procedure was not possible. Results In total, 188 superficial oesophageal adenocarcinomas were included with a median follow-up of 34 months. No lymph node metastases occurred for intramucosal oesophageal adenocarcinomas ( n = 135) even with high-risk histological features. Among submucosal oesophageal adenocarcinomas, only tumours with lymphovascular invasion or poorly differentiated cancer or with a depth of invasion >1000 µm developed lymph node metastasis tumours ( n = 10/53; 18.9%; hazard ratio 12.04). No metastatic evolution occurred under a 1000-µm threshold for all low-risk tumours (0/25), nor under 1200 µm (0/1) and three over this threshold (3/13, 23.1%). Conclusion Intramucosal and low-risk tumours with shallow submucosal invasion up to 1200 µm were not associated with lymph node metastasis during follow-up. In case of high-risk features and/or deep submucosal invasion, endoscopic resections are not sufficient to eliminate the risk of lymph node metastasis, and surgical oesophagectomy should be carried out. These results must be confirmed by larger prospective series.

PS02.093: LYMPH NODE METASTASES IN T1 OESOPHAGEAL ADENOCARCINOMA: WHAT IS THE REAL RISK IN EARLY OESOPHAGEAL CANCER?

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 147-147
Author(s):  
David Mitchell ◽  
Gregory Falk ◽  
Sashi Yeluri
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Oesophageal Cancer ◽  
Oesophageal Adenocarcinoma ◽  
Endoscopic Management ◽  
Lymph Node Yield ◽  
Node Metastasis ◽  
Node Yield ◽  
Positive Lymph Nodes

Abstract Background Lymph node status is regarded as the most important factor for prognosis for oesophageal cancer. T1 oesophageal adenocarcinoma management has shifted from oesophagectomy only to include endoscopic management as part of the algorithm, with some bodies (National Comprehensive Cancer Network (NCCN) 2016) recommending it for management of T1a disease and selected T1b disease. We reviewed the literature to assess the true risk of lymph node metastasis in patients with T1 oesophageal adenocarcinoma. Methods Medline, Embase, Pubmed and Cochrane where searched for manuscripts in english reviewing the lymph node metastasis in superficial (T1) oesophageal adenocarcinoma. The main outcome was reviewing the risk of lymph node metastasis in T1a and T1b oesophageal adenocarcinoma. Secondary outcomes looked at the rate of lymph node metastasis for T1b cancers based on degree of submucosal involvement (SM1, SM2 and SM3). Studies were excluded if neo-adjuvant chemotherapy or radiotherapy were received and if the surgical lymph node yield was < 15 lymph nodes. Results 38 Studies were identified. 22 studies were excluded due to low lymph node yield (< 15) or insufficient statistical analysis. For the 16 studies, a total of 1422 cases were included. 533 patients had T1a adenocarcinoma with 11 patients demonstrating positive lymph nodes (2%). 849 had T1b adenocarcinoma with 189 patients demonstrating positive lymph nodes (22%). Eight Studies did subgroup analysis of T1b lesions with a total of 365 patients identified. The rate of lymph node positivity for SM1, SM2 and SM3 was 17.9%, 16.6% and 29.6% respectively. Conclusion Early oesophageal adenocarcinoma (T1) is increasing in prevalence due to surveillance of pre-malignant conditions (Barrett's Oesophagus). Recently some bodies recommend the use of endoscopic mucosal resection as first line therapy for T1a disease. It is important to inform our patients the risk of lymph node metastasis is low but significant (2%). Given in specialised units, oesophagectomy can be performed with low mortality (< 1%) and morbidity with good quality of life it is justifiable to recommend oesophagectomy or endoscopic management in patients who are fit enough for surgery. For T1b disease an oesophagectomy is the gold standard of treatment given the significant risk of lymph node positivity (22%). Disclosure All authors have declared no conflicts of interest.

scholarly journals Upregulation of miR-17-92 cluster is associated with progression and lymph node metastasis in oesophageal adenocarcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Patrick Sven Plum ◽  
Ute Warnecke-Eberz ◽  
Uta Drebber ◽  
Seung-Hun Chon ◽  
Hakan Alakus ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oesophageal Adenocarcinoma ◽  
Node Metastasis
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