scholarly journals Lack of correlation of stem cell markers in breast cancer stem cells

2014 ◽  
Vol 110 (8) ◽  
pp. 2063-2071 ◽  
Author(s):  
Y Liu ◽  
R Nenutil ◽  
M V Appleyard ◽  
K Murray ◽  
M Boylan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Stem Cell Markers ◽  
Breast Cancer Stem Cells ◽  
Cell Markers

Abstract 3872: Differentially expressed stem cell markers in breast cancer stem cells

2011 ◽  
Author(s):  
Aline RM Lobba ◽  
Maria Fernanda PAD Forni ◽  
Carolina Perozzi ◽  
Ana Claúdia O. Carreira ◽  
Leticia Labriola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Differentially Expressed ◽  
Stem Cell Markers ◽  
Breast Cancer Stem Cells ◽  
Cell Markers

scholarly journals The effects and mechanisms of SLC34A2 on maintaining stem cell-like phenotypes in CD147+breast cancer stem cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (4) ◽  
pp. 101042831769592 ◽  
Author(s):  
Yonggang Lv ◽  
Ting Wang ◽  
Jing Fan ◽  
Zhenzhen Zhang ◽  
Juliang Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells

scholarly journals Gastric Cancer Stem Cells Survive in Stress Environments via Their Autophagy System

2020 ◽  
Author(s):  
Shingo Togano ◽  
Masakazu Yashiro ◽  
Go Masuda ◽  
Atsushi Sugimoto ◽  
Yuichiro Miki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Electron Microscope ◽  
Cancer Stem Cells ◽  
Western Blot ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Autophagy Inhibitor ◽  
Stress Environments

Abstract Background: It has been reported that cancer stem cells (CSCs) play an important role in the progression of carcinoma and have a high potential for survival in various stress environments such as starvation and hypoxia. However, the mechanisms responsible for the capacity of CSCs to survive under stresses have been unclear. The aim of this study was to clarify the significance of the autophagy systems of CSCs under stress environments.Methods: Four human gastric cancer cell line, OCUM-12, OCUM-2MD3, MKN-45 and MKN-74 were used. Side population (SP) cells were sorted from the parent OCUM-12 and OCUM-2MD3, as CSC rich cells. The expression of stem cell markers was examined by RT-PCR. The viability of cancer cells under starvation and hypoxia (1%O2) was evaluated by MTT assay with or without the autophagy inhibitor, chloroquine. The expression level of the autophagy molecule LC3-II was examined by western blot. The numbers of autophagosomes and autolysosomes were counted by electron microscope.Results: SP cells of OCUM-12 showed a higher expression of stem cell markers and higher viability in starvation and hypoxia. Western blot and electron microscope examinations indicated that the autophagy was more induced in SP cells than in parent cells. The autophagy inhibitor significantly decreased the viability and the proportion of SP cells under the stress environments.Conclusions: Cancer stem cells of gastric cancer might maintain their viability under stress environments of starvation and hypoxia via the autophagy system. Autophagy inhibitors might be a promising therapeutic agent for gastric cancer.

Breast Cancer Stem Cells and Sex Steroid Hormones

2019 ◽  
Vol 14 (5) ◽  
pp. 398-404 ◽  
Author(s):  
Iván Flores-Ramírez ◽  
Noemi Baranda-Avila ◽  
Elizabeth Langley
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Breast Cancer Stem Cells ◽  
Tumor Initiating Cells ◽  
Intrinsic Resistance

Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to stemness, and the role of sex steroid hormones in BCSC regulation.

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