scholarly journals PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma

2012 ◽  
Vol 106 (9) ◽  
pp. 1535-1542 ◽  
Author(s):  
T Matsuoka ◽  
M Yashiro ◽  
N Nishioka ◽  
K Hirakawa ◽  
K Olden ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Scirrhous Gastric Carcinoma

Novel models for human scirrhous gastric carcinoma in vivo

2004 ◽  
Vol 95 (11) ◽  
pp. 893-900 ◽  
Author(s):  
Satoru Takemura ◽  
Masakazu Yashiro ◽  
Takeshi Sunami ◽  
Masashige Tendo ◽  
Kosei Hirakawa
Keyword(s):  
Gastric Carcinoma ◽  
Scirrhous Gastric Carcinoma

scholarly journals Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Yantao Du ◽  
Zhaojun Liu ◽  
Liankun Gu ◽  
Jing Zhou ◽  
Bu-dong Zhu ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Cpg Islands ◽  
Human Gastric Carcinoma

Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine

Phytomedicine ◽  
2007 ◽  
Vol 14 (5) ◽  
pp. 353-359 ◽  
Author(s):  
J.-Y. Sun ◽  
M.-Z. Zhu ◽  
S.-W. Wang ◽  
S. Miao ◽  
Y.-H. Xie ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Human Gastric Carcinoma

scholarly journals A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma

Oncogene ◽  
2001 ◽  
Vol 20 (39) ◽  
pp. 5525-5532 ◽  
Author(s):  
Shinji Tanaka ◽  
Keishi Sugimachi ◽  
Hiroshi Saeki ◽  
Junko Kinoshita ◽  
Takefumi Ohga ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Novel Variant ◽  
Scirrhous Gastric Carcinoma ◽  
Type C ◽  
Von Willebrand

scholarly journals ID: 1023 All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth

2017 ◽  
Vol 4 (S) ◽  
pp. 98
Author(s):  
P H Nguyen ◽  
J Giraud ◽  
C Staedel ◽  
L Chambonnier ◽  
P Dubus ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gastric Carcinoma ◽  
Tumor Growth ◽  
Cell Cycle Progression ◽  
3D Culture ◽  
All Trans Retinoic Acid

Gastric carcinoma is the third leading cause of cancer-related death worldwide. This cancer, most of the time metastatic, is essentially treated by surgery associated with conventional chemotherapy, and has a poor prognosis. The existence of cancer stem cells (CSC) expressing CD44 and a high aldehyde dehydrogenase (ALDH) activity has recently been demonstrated in gastric carcinoma and has opened new perspectives to develop targeted therapy. In this study, we evaluated the effects of all-transretinoic acid (ATRA) on CSCs in human gastric carcinoma. ATRA effects were evaluated on the proliferation and tumorigenic properties of gastric carcinoma cells from patient-derived tumors and cell lines in conventional 2D cultures, in 3D culture systems (tumorsphere assay) and in mouse xenograft models. ATRA inhibited both tumorspheres initiation and growth in vitro, which was associated with a cell-cycle arrest through the upregulation of cyclin-dependent kinase (CDK) inhibitors and the downregulation of cell-cycle progression activators. More importantly, ATRA downregulated the expression of the CSC markers CD44 and ALDH as well as stemness genes such as Klf4 and Sox2 and induced differentiation of tumorspheres. Finally, 2 weeks of daily ATRA treatment were sufficient to inhibit gastric tumor progression in vivo, which was associated with a decrease in CD44, ALDH1, Ki67 and PCNA expression in the remaining tumor cells. Administration of ATRA appears to be a potent strategy to efficiently inhibit tumor growth and more importantly to target gastric CSCs in both intestinal and diffuse types of gastric carcinoma.

A tumor-associated antigen in the scirrhous gastric carcinoma cell line MK-01 defined by monoclonal antibody S202

1989 ◽  
Vol 19 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Takashi Yokota ◽  
Takashi Masuko ◽  
Toshiharu Yamaguchi ◽  
Kazuya Kitamura ◽  
Toshio Takahashi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Gastric Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Gastric Carcinoma Cell ◽  
Gastric Carcinoma Cell Line ◽  
Tumor Associated Antigen ◽  
Scirrhous Gastric Carcinoma

scholarly journals Adenovirus-mediated ING4 expression reduces multidrug resistance of human gastric carcinoma cells in vitro and in vivo

2013 ◽  
Vol 30 (5) ◽  
pp. 2187-2194 ◽  
Author(s):  
ZONG-LEI MAO ◽  
SONG-BING HE ◽  
WEI-HUA SHENG ◽  
XIAO-QIANG DONG ◽  
JI-CHENG YANG
Keyword(s):  
Multidrug Resistance ◽  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Human Gastric Carcinoma ◽  
Human Gastric Carcinoma Cells

scholarly journals Common Epstein-Barr virus (EBV) type-1 variant strains in both malignant and benign EBV-associated disorders

Blood ◽  
1996 ◽  
Vol 87 (4) ◽  
pp. 1579-1585 ◽  
Author(s):  
V Schuster ◽  
G Ott ◽  
S Seidenspinner ◽  
HW Kreth
Keyword(s):  
Gastric Carcinoma ◽  
Epstein Barr Virus ◽  
Hodgkin's Lymphoma ◽  
Sequence Pattern ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr

In the present study, Epstein-Barr virus (EBV) isolates from 18 malignant tumors (angioimmunoblastic lymphadenopathy [AILD], n = 4; Hodgkin's disease [HD], n = 3; pleomorphic T-cell non-Hodgkin's lymphoma [T-NHL], n = 1; B-cell non-Hodgkin's lymphoma [B-NHL], n = 8; gastric carcinoma, n = 2) as well as from 10 tonsils of EBV- seropositive children and from peripheral blood mononuclear cells of 12 children with uncomplicated infectious mononucleosis (IM) and of a boy with severe chronic active EBV infection were genotyped in the EBV nuclear antigen-2 (EBNA-2) gene. A total of 40 of 41 isolates harbored EBV type 1; in 1 specimen (tonsil), only EBV type 2 was found. Further molecular characterization of EBV type-1 wild-type isolates in the EBNA- 2 gene and in the 40-kb distant EBV-encoded small RNAs (EBER) region showed that different groups of stable EBV type-1 variant strains exist in vivo both in benign and malignant lymphatic tissue. Group 1 is composed of EBV type-1 isolates (B-NHL, n = 3; T-NHL, n = 1; HD, n = 1; IM, n = 4) that showed a B95–8-like DNA sequence pattern in both viral genes. Group 2 isolates (HD, n = 1; AILD, n = B-NHL, n = 1; tonsils of EBV-seropositive children, n = 9; IM, n = 20 showed a nucleotide change at position 49095 in the EBNA-2 gene, leading to an amino acid substitution (Pro-->Ser), and EBV type-2 sequences in the EBER region. EBV type-1 isolates that fall into group 3 (AILD, n = 3; HD, n = 1; B- NHL, n = 4; gastric carcinoma, n = 2; IM, n = 6; severe chronic active EBV infection, n = 1) were characterized by typical nucleotide changes and a 3-bp insertion (CTC; extra Leu residue) in the EBNA-2 gene and an EBV type-2-specific sequence pattern in the EBER region. These EBV type- 1 variant strains may represent the most prevalent circulating EBV type- 1 strains in the exposed population and seem not to be restricted to a certain EBV-associated disease or tumor type. However, analysis of more EBV isolates from benign and malignant lesions must show whether more EBV type-1 substrains exist in vivo.

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