Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine

Phytomedicine ◽  
2007 ◽  
Vol 14 (5) ◽  
pp. 353-359 ◽  
Author(s):  
J.-Y. Sun ◽  
M.-Z. Zhu ◽  
S.-W. Wang ◽  
S. Miao ◽  
Y.-H. Xie ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Human Gastric Carcinoma

scholarly journals Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Yantao Du ◽  
Zhaojun Liu ◽  
Liankun Gu ◽  
Jing Zhou ◽  
Bu-dong Zhu ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Cpg Islands ◽  
Human Gastric Carcinoma

scholarly journals Adenovirus-mediated ING4 expression reduces multidrug resistance of human gastric carcinoma cells in vitro and in vivo

2013 ◽  
Vol 30 (5) ◽  
pp. 2187-2194 ◽  
Author(s):  
ZONG-LEI MAO ◽  
SONG-BING HE ◽  
WEI-HUA SHENG ◽  
XIAO-QIANG DONG ◽  
JI-CHENG YANG
Keyword(s):  
Multidrug Resistance ◽  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Human Gastric Carcinoma ◽  
Human Gastric Carcinoma Cells

Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo

Tumor Biology ◽  
2010 ◽  
Vol 32 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Jie Gao ◽  
Ningning Sai ◽  
Chengqin Wang ◽  
Xiehuang Sheng ◽  
Qianqian Shao ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Human Gastric Carcinoma ◽  
Human Gastric Carcinoma Cells

scholarly journals ID: 1023 All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth

2017 ◽  
Vol 4 (S) ◽  
pp. 98
Author(s):  
P H Nguyen ◽  
J Giraud ◽  
C Staedel ◽  
L Chambonnier ◽  
P Dubus ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gastric Carcinoma ◽  
Tumor Growth ◽  
Cell Cycle Progression ◽  
3D Culture ◽  
All Trans Retinoic Acid

Gastric carcinoma is the third leading cause of cancer-related death worldwide. This cancer, most of the time metastatic, is essentially treated by surgery associated with conventional chemotherapy, and has a poor prognosis. The existence of cancer stem cells (CSC) expressing CD44 and a high aldehyde dehydrogenase (ALDH) activity has recently been demonstrated in gastric carcinoma and has opened new perspectives to develop targeted therapy. In this study, we evaluated the effects of all-transretinoic acid (ATRA) on CSCs in human gastric carcinoma. ATRA effects were evaluated on the proliferation and tumorigenic properties of gastric carcinoma cells from patient-derived tumors and cell lines in conventional 2D cultures, in 3D culture systems (tumorsphere assay) and in mouse xenograft models. ATRA inhibited both tumorspheres initiation and growth in vitro, which was associated with a cell-cycle arrest through the upregulation of cyclin-dependent kinase (CDK) inhibitors and the downregulation of cell-cycle progression activators. More importantly, ATRA downregulated the expression of the CSC markers CD44 and ALDH as well as stemness genes such as Klf4 and Sox2 and induced differentiation of tumorspheres. Finally, 2 weeks of daily ATRA treatment were sufficient to inhibit gastric tumor progression in vivo, which was associated with a decrease in CD44, ALDH1, Ki67 and PCNA expression in the remaining tumor cells. Administration of ATRA appears to be a potent strategy to efficiently inhibit tumor growth and more importantly to target gastric CSCs in both intestinal and diffuse types of gastric carcinoma.

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