scholarly journals Upregulation of cancer-associated myofibroblasts by TGF-β from scirrhous gastric carcinoma cells

2011 ◽  
Vol 105 (7) ◽  
pp. 996-1001 ◽  
Author(s):  
Y Fuyuhiro ◽  
M Yashiro ◽  
S Noda ◽  
S Kashiwagi ◽  
J Matsuoka ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Scirrhous Gastric Carcinoma

A novel K-samII/FGF-R2 autophosphorylation inhibitor is therapeutically useful for scirrhous gastric carcinoma with K-samII amplification

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 14070-14070
Author(s):  
M. Yashiro ◽  
K. Nakamura ◽  
T. Sawada ◽  
H. Kawajiri ◽  
T. Shimizu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Gastric Carcinoma ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Growth Factor Receptor ◽  
Carcinoma Cells ◽  
Apoptosis Pathway ◽  
Scirrhous Gastric Cancer ◽  
Scirrhous Gastric Carcinoma

14070 Background: Scirrhous gastric carcinoma, a diffusely infiltrating also known as linitis plastica-type carcinoma, carries the highest mortality of all gastric cancers. Scirrhous carcinoma cells with amplification of the activated K-samII gene, which encodes fibroblast growth factor receptor type 2 (FGF-R2), have a growth advantage during tumor progression The poor prognosis carried by scirrhous gastric cancer is closely associated with amplification of the K-samII/FGF-R2, a tyrosine kinase growth factor receptor. Ki23057, a newly developed small molecule acting K-samII/FGF-R2 inhibitor, is a kinase inhibitor that competes with ATP for the binding site in the kinase, thus strongly blocking phosphorylation of FGF-R2. The aim of the current study is to clarify the possibility of molecular target therapy with Ki23057 for treating scirrhous gastric cancer. Methods: Five human gastric cancer cell lines were used. OCUM-2MD3 and OCUM-8 were derived from scirrhous carcinomas. MKN-7, MKN-45 and MKN-74 cells were derived from non-scirrhous carcinomas. In vitro effects of Ki23057 on cell growth were determined by calculating the number of cancer cells. The influences of Ki23057 on the MAP kinase and PI3 kinase signaling pathways and the apoptosis pathway in the gastric cancer cells were also examined. For in vivo experiments, the Ki23057 was administered orally to mouse models of peritoneal dissemination. Results: K-samII amplification was found in OCUM-2MD3 and OCUM-8 cells, but not in MKN-7, MKN-45, or MKN-74 cells. Ki23057 significantly inhibited the proliferation of scirrhous cancer cells, but not non- scirrhous gastric carcinoma cells. Ki23057 decreased phosphorylation of K-samII/FGF-R2, ERK and Akt, and increased apoptosis in scirrhous cancer lines. The oral Ki23057 administration significantly (p<0.001) prolonged survival of mice with peritoneal dissemination following injection of OCUM-2MD3 scirrhous cancer cells. Conclusions: A novel K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, appears therapeutically promising in scirrhous gastric carcinoma with K-samII amplification. No significant financial relationships to disclose.

scholarly journals Stromal Fibroblasts Mediate Extracellular Matrix Remodeling and Invasion of Scirrhous Gastric Carcinoma Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85485 ◽  
Author(s):  
Hideki Yamaguchi ◽  
Nachi Yoshida ◽  
Miho Takanashi ◽  
Yuumi Ito ◽  
Kiyoko Fukami ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Stromal Fibroblasts ◽  
Scirrhous Gastric Carcinoma

scholarly journals ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion

Oncogene ◽  
2010 ◽  
Vol 30 (12) ◽  
pp. 1413-1421 ◽  
Author(s):  
R Yagi ◽  
M Tanaka ◽  
K Sasaki ◽  
R Kamata ◽  
Y Nakanishi ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Gastric Carcinoma ◽  
Peritoneal Dissemination ◽  
Carcinoma Cells ◽  
Scirrhous Gastric Carcinoma ◽  
Adhesion And Invasion

Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells

2021 ◽  
Vol 85 (3) ◽  
pp. 553-561
Author(s):  
Chenxia Ren ◽  
Cuiling Wu ◽  
Changqing Yang ◽  
Changhong Lian
Keyword(s):  
Cell Cycle ◽  
Gastric Carcinoma ◽  
Vitamin C ◽  
Cyclin D1 ◽  
Bioinformatics Analysis ◽  
Carcinoma Cells ◽  
Cell Cycle Pathway ◽  
Differential Gene ◽  
Regulation Of Cell Cycle ◽  
Amp Activated Protein Kinase

ABSTRACT Vitamin C has re-emerged as a promising anticancer agent. This study attempts to analyze the differential gene expression of profiles GSE11919 to look for some clues, and the most significant cell cycle pathway caused by vitamin C was identified by integrated bioinformatics analysis. Inspired by this, we investigated the effect of vitamin C treatment on gastric carcinoma cells by detection of cell cycle, apoptosis, and autophagy. Vitamin C significantly elevated the percentage of cells at G0/G1 phase, whereas the percentage of S phase cells was decreased. Meanwhile, vitamin C treatment resulted in downregulation of cell cycle-related protein Cyclin D1. We deduced that the downregulation of Cyclin D1 by vitamin C accompanied by significantly increased 5′AMP-activated protein kinase and induced autophagy in MKN45 cells. These results suggest that vitamin C has the antiproliferation effect on gastric carcinoma cells via the regulation of cell cycle and autophagy by Cyclin D1.

CD40 signaling activated by agonistic anti-CD40 monoclonal antibody 5C11 has different effects on biological behavior of gastric carcinoma cells

2010 ◽  
Vol 131 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Rui Li ◽  
Wei-chang Chen ◽  
Wei-peng Wang ◽  
Wen-yan Tian ◽  
Xue-guang Zhang
Keyword(s):  
Monoclonal Antibody ◽  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Biological Behavior

Dynamic characterization of drug resistance and heterogeneity of the gastric cancer cell BGC823 using single-cell Raman spectroscopy

The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 164-174 ◽  
Author(s):  
Yong Zhang ◽  
Ludi Jin ◽  
Jingjing Xu ◽  
Yuezhou Yu ◽  
Lin Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Raman Spectroscopy ◽  
Drug Resistance ◽  
Gastric Carcinoma ◽  
Single Cell ◽  
Gastric Cancer Cell ◽  
Carcinoma Cells ◽  
Dynamic Characterization ◽  
Human Gastric Carcinoma Cells

Drug resistance and heterogeneous characteristics of human gastric carcinoma cells (BGC823) under the treatment of paclitaxel (PTX) were investigated using single-cell Raman spectroscopy (RS).

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