Dynamic characterization of drug resistance and heterogeneity of the gastric cancer cell BGC823 using single-cell Raman spectroscopy

The Analyst ◽  
2018 ◽  
Vol 143 (1) ◽  
pp. 164-174 ◽  
Author(s):  
Yong Zhang ◽  
Ludi Jin ◽  
Jingjing Xu ◽  
Yuezhou Yu ◽  
Lin Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Raman Spectroscopy ◽  
Drug Resistance ◽  
Gastric Carcinoma ◽  
Single Cell ◽  
Gastric Cancer Cell ◽  
Carcinoma Cells ◽  
Dynamic Characterization ◽  
Human Gastric Carcinoma Cells

Drug resistance and heterogeneous characteristics of human gastric carcinoma cells (BGC823) under the treatment of paclitaxel (PTX) were investigated using single-cell Raman spectroscopy (RS).

scholarly journals Adenovirus-mediated ING4 expression reduces multidrug resistance of human gastric carcinoma cells in vitro and in vivo

2013 ◽  
Vol 30 (5) ◽  
pp. 2187-2194 ◽  
Author(s):  
ZONG-LEI MAO ◽  
SONG-BING HE ◽  
WEI-HUA SHENG ◽  
XIAO-QIANG DONG ◽  
JI-CHENG YANG
Keyword(s):  
Multidrug Resistance ◽  
Gastric Carcinoma ◽  
Carcinoma Cells ◽  
Human Gastric Carcinoma ◽  
Human Gastric Carcinoma Cells

Improvement of the Chemosensitivity of Gastric Carcinoma Cells by Celastrus orbiculatus Extracts

2021 ◽  
Vol 20 (2) ◽  
pp. 282-287
Author(s):  
Yuling Wang ◽  
Kai Wang ◽  
Shilei Ding ◽  
Shuguang Wang ◽  
Rubin Gu
Keyword(s):  
Gastric Carcinoma ◽  
Tumor Cells ◽  
Carcinoma Cells ◽  
High Morbidity ◽  
Drug Resistant ◽  
Celastrus Orbiculatus ◽  
Protein Markers ◽  
Gastric Cells ◽  
Human Gastric Carcinoma Cells ◽  
Selection Of

Gastric carcinoma is one of the most prevalent malignancies with high morbidity and mortality. While chemotherapy is the major means for the management gastric carcinoma, tumors gradually exhibit drug resistance. Therefore, there is a need for agents capable of enhancing the sensitivity of tumor cells to chemotherapy. Herein, we have examined the effect of Celastrus orbiculatus extracts on chemosensitivity of drug resistant gastric carcinoma cells. Human gastric carcinoma cells (MGC-803 and SGC-7901) were cultured in the presence of cisplatin for the selection of drug resistant gastric cells. Next, the effect of C. orbiculatus extracts on multiplication capacity of drug resistant MGC-803 and SGC-7901 cells was examined by a variety of measures. Following C. orbiculatus extract treatment, the multiplication and invasiveness of drug resistant MGC-803 and SGC-7901 cells declined remarkably, with increased apoptosis and decreased levels of β-catenin, c-Myc, and cyclin D1 proteins, protein markers critical to cell proliferation, differentiation, and apoptosis. In summary, C. orbiculatus extract can effectively improve the sensitivity of cisplatin resistant gastric carcinoma cells to cisplatin and promote the apoptosis of tumor cells through the inhibition of the expression of proteins associated with the Wnt/β-catenin axis.

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