scholarly journals Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia

1997 ◽  
Vol 76 (9) ◽  
pp. 1115-1118 ◽  
Author(s):  
CS Mantzoros ◽  
A Tzonou ◽  
LB Signorello ◽  
M Stampfer ◽  
D Trichopoulos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Growth Factor ◽  
Prostatic Hyperplasia ◽  
Insulin Like Growth Factor

Evaluating Serum Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein 3 as Markers in Prostate Cancer Diagnosis

2016 ◽  
Vol 31 (3) ◽  
pp. 317-323 ◽  
Author(s):  
Giulia Rainato ◽  
Aline S.C. Fabricio ◽  
Matelda Zancan ◽  
Lucia Peloso ◽  
Ruggero Dittadi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Growth Factor ◽  
Binding Protein ◽  
Serum Levels ◽  
Prostatic Hyperplasia ◽  
Insulin Like Growth Factor ◽  
Operating Characteristics ◽  
Factor Binding ◽  
Total Psa

Background Prostate-specific antigen (PSA) lacks specificity and sensitivity in discriminating prostate cancer (PCa) from benign prostatic hyperplasia (BPH) when the total PSA (tPSA) level is between 4 and 10 ng/mL. It remains to be investigated if additional tumor-associated molecules may improve the PCa diagnostic accuracy. The aim of the present study was to investigate whether serum levels of insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3) and their combinations with PSA may enhance the diagnosis of PCa. Methods Serum tPSA and free PSA (fPSA) levels were measured using an automated chemiluminescence-based method. IGF1 and IGFBP3 levels were evaluated by radioimmunoassays in a prospectively and consecutively enrolled subset of 149 patients with tPSA ≤10 ng/mL made up of patients with benign prostatic hyperplasia (BPH; n = 113) and PCa (n = 36). Results IGF1 and IGFBP3 serum levels did not significantly differ between the PCa and BPH groups. No important correlation was found between the IGF molecules and PSA isoforms in both groups. Statistical analysis of the combination of markers indicated that only the free/total PSA ratio (f/tPSA%) was informative and independent in predicting the presence of PCa, considering that for high values of this percentage (17%) the probability of finding PCa decreased. Receiver operating characteristics areas under the curve (AUC) for IGF1 and IGFBP3 were not informative (AUC ~0.5 in both cases) contrary to the AUC for f/tPSA% (AUC = 0.689, p = 0.0002). Conclusions The present study showed that neither IGF1 and IGFBP3 alone nor in combination with PSA enhance the diagnostic performance of PSA in PCa.

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