scholarly journals Presence of exon 5-deleted oestrogen receptor in human breast cancer: functional analysis and clinical significance

1997 ◽  
Vol 75 (8) ◽  
pp. 1173-1184 ◽  
Author(s):  
AJ Desai ◽  
YA Luqmani ◽  
JE Walters ◽  
RC Coope ◽  
B Dagg ◽  
...  
2018 ◽  
Vol 49 (2) ◽  
pp. 91
Author(s):  
N. G. KOSTOMITSOPOULOS (Ν.Γ. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ)

The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences. The study of the role of oestrogen receptor on the expression of the mitogenic actionof oestrogens and oncogenesis lead biomedical research in new approaches of the treatment of oestrogen-dependent tumors by using antioestrogens. Main mechanism of action of antioestrogens is the prevention of oestrogen action by blocking the binding of oestradiol to the oestrogen receptor. Tamoxifen, the most wellknown antioestrogen, is widely used as adjuvant therapy in all stages of human breast cancer. Recently interest is focused on the potential use of "pure" antioestrogens. The use of antioestrogens in veterinary oncology is also under discussion.


2020 ◽  
Vol 11 ◽  
Author(s):  
Xiaoxue Xie ◽  
Junying Zhang ◽  
Zhongyuan Shi ◽  
Wanmei Liu ◽  
Xinlei Hu ◽  
...  

2020 ◽  
Vol Volume 13 ◽  
pp. 6593-6601
Author(s):  
Xiaoyan Li ◽  
Liu Tian ◽  
Lina Zhang ◽  
Baojin Xu ◽  
Yong Zhang ◽  
...  

2013 ◽  
Vol 49 (6) ◽  
pp. 1176-1186 ◽  
Author(s):  
Liane M. McGlynn ◽  
Sian Tovey ◽  
John M.S. Bartlett ◽  
Julie Doughty ◽  
Timothy G. Cooke ◽  
...  

2017 ◽  
Vol 37 (3) ◽  
pp. 1707-1715 ◽  
Author(s):  
Shuo Cai ◽  
Ping-Hui Sun ◽  
Jeyna Resaul ◽  
Lei Shi ◽  
Aihua Jiang ◽  
...  

2004 ◽  
Vol 91 (5) ◽  
pp. 959-965 ◽  
Author(s):  
Y Sagara ◽  
K Mimori ◽  
K Yoshinaga ◽  
F Tanaka ◽  
K Nishida ◽  
...  

1994 ◽  
Vol 30 (11) ◽  
pp. 1663-1669 ◽  
Author(s):  
S.R.D. Johnston ◽  
K.A. MacLennan ◽  
N.P.M. Sacks ◽  
J. Salter ◽  
I.E. Smith ◽  
...  

2011 ◽  
Author(s):  
Jack Wu ◽  
Suling Liu ◽  
Gang Liu ◽  
Alan Dombkowski ◽  
Judith Abrams ◽  
...  

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