Interactions between MAP kinase and oestrogen receptor in human breast cancer

2013 ◽  
Vol 49 (6) ◽  
pp. 1176-1186 ◽  
Author(s):  
Liane M. McGlynn ◽  
Sian Tovey ◽  
John M.S. Bartlett ◽  
Julie Doughty ◽  
Timothy G. Cooke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Map Kinase ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Human Breast

scholarly journals Oestrogen receptors and antioestrogen treatment of hormone-dependent tumours

2018 ◽  
Vol 49 (2) ◽  
pp. 91
Author(s):  
N. G. KOSTOMITSOPOULOS (Ν.Γ. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ)
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Dna Sequences ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Specific Gene ◽  
Oestrogen Receptors ◽  
Human Breast ◽  
Potential Use

The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences. The study of the role of oestrogen receptor on the expression of the mitogenic actionof oestrogens and oncogenesis lead biomedical research in new approaches of the treatment of oestrogen-dependent tumors by using antioestrogens. Main mechanism of action of antioestrogens is the prevention of oestrogen action by blocking the binding of oestradiol to the oestrogen receptor. Tamoxifen, the most wellknown antioestrogen, is widely used as adjuvant therapy in all stages of human breast cancer. Recently interest is focused on the potential use of "pure" antioestrogens. The use of antioestrogens in veterinary oncology is also under discussion.

Modulation of Bcl-2 and Ki-67 expression in oestrogen receptor-positive human breast cancer by tamoxifen

1994 ◽  
Vol 30 (11) ◽  
pp. 1663-1669 ◽  
Author(s):  
S.R.D. Johnston ◽  
K.A. MacLennan ◽  
N.P.M. Sacks ◽  
J. Salter ◽  
I.E. Smith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Human Breast ◽  
Ki 67

The clinical relevance of oestrogen receptor binding to oligo(dT)—cellulose in human breast cancer

1986 ◽  
Vol 14 (5) ◽  
pp. 961-962
Author(s):  
GIRISH PARMAR ◽  
KATHRYN A. PHILIPSON ◽  
MICHAEL HERSHMAN ◽  
MURDOCH G. ELDER ◽  
CHRISTOPHER B. WOOD ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Receptor Binding ◽  
Clinical Relevance ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Human Breast

scholarly journals Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells

Open Biology ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 150262 ◽  
Author(s):  
Chin-Yo Lin ◽  
Erica L. Kleinbrink ◽  
Fabien Dachet ◽  
Juan Cai ◽  
Donghong Ju ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Signalling Pathways ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Non Coding Rnas

Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncRNA transcriptome of oestrogen receptor positive human breast cancer cells following treatment with oestrogen, and identified 127 oestrogen-responsive lncRNAs. Consistent with the emerging evidence that most human lncRNA genes lack homologues outside of primates, our evolutionary analysis revealed primate-specific lncRNAs downstream of oestrogen signalling. We demonstrate, using multiple functional assays to probe gain- and loss-of-function phenotypes in two oestrogen receptor positive human breast cancer cell lines, that two primate-specific oestrogen-responsive lncRNAs identified in this study (the oestrogen-repressed lncRNA BC041455, which reduces cell viability, and the oestrogen-induced lncRNA CR593775, which increases cell viability) exert previously unrecognized functions in cell proliferation and growth factor signalling pathways. The results suggest that oestrogen-responsive lncRNAs are capable of altering the proliferation and viability of human breast cancer cells. No effects on cellular phenotypes were associated with control transfections. As heretofore unappreciated components of key signalling pathways in cancers, including the MAP kinase pathway, lncRNAs hence represent a novel mechanism of action for oestrogen effects on cellular proliferation and viability phenotypes. This finding warrants further investigation in basic and translational studies of breast and potentially other types of cancers, has broad relevance to lncRNAs in other nuclear hormone receptor pathways, and should facilitate exploiting and targeting these cell viability modulating lncRNAs in post-genomic therapeutics.

Oestrogen receptor expression in human breast cancer during long-term fulvestrant treatment

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 536-536 ◽  
Author(s):  
J. Robertson ◽  
E. Gutteridge ◽  
K. L. Cheung ◽  
S. Pinder ◽  
A. Wakeling
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Receptor Expression ◽  
Human Breast
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