scholarly journals The novel anti-oestrogen idoxifene inhibits the growth of human MCF-7 breast cancer xenografts and reduces the frequency of acquired anti-oestrogen resistance

1997 ◽  
Vol 75 (6) ◽  
pp. 804-809 ◽  
Author(s):  
SRD Johnston ◽  
S Riddler ◽  
BP Haynes ◽  
R A'Hern ◽  
IE Smith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
The Novel ◽  
Breast Cancer Xenografts ◽  
Mcf 7

scholarly journals Inhibitory Effects of Calcitriol on the Growth of MCF-7 Breast Cancer Xenografts in Nude Mice: Selective Modulation of Aromatase Expression in vivo

2011 ◽  
Vol 2 (3) ◽  
pp. 190-202 ◽  
Author(s):  
Srilatha Swami ◽  
Aruna V. Krishnan ◽  
Jennifer Y. Wang ◽  
Kristin Jensen ◽  
Lihong Peng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nude Mice ◽  
Inhibitory Effects ◽  
Aromatase Expression ◽  
Selective Modulation ◽  
Breast Cancer Xenografts ◽  
Mcf 7

Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis

2008 ◽  
Vol 118 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Zengshan Li ◽  
Latonya Carrier ◽  
Aditi Belame ◽  
Arunthavarani Thiyagarajah ◽  
Virgilio A. Salvo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nude Mice ◽  
Breast Cancer Xenografts ◽  
Mcf 7

scholarly journals Doxorubicin induces drug resistance and expression of the novel CD44st via NF-κB in human breast cancer MCF-7 cells

2014 ◽  
Vol 31 (6) ◽  
pp. 2735-2742 ◽  
Author(s):  
XIN JIAN FANG ◽  
HUA JIANG ◽  
YA QUN ZHU ◽  
LI YUAN ZHANG ◽  
QIU HONG FAN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Human Breast Cancer ◽  
The Novel ◽  
Human Breast ◽  
Mcf 7

scholarly journals Antiproliferative Effect of Grammatophyllum speciosum Ethanolic Extract and Its Bioactive Compound on Human Breast Cancer Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Verisa Chowjarean ◽  
Kamala Sadabpod
Keyword(s):  
Breast Cancer ◽  
Colony Formation ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Ethanolic Extract ◽  
Bioactive Compound ◽  
The Novel ◽  
Human Breast ◽  
Phosphorylated Akt ◽  
Mcf 7

Background/Aim. Grammatophyllum speciosum Blume exhibits various promising pharmacological activities. However, its effect on breast cancer has not been determined. Materials and Methods. The antiproliferation effects of the G. speciosum pseudobulb ethanolic extract (GSE) and isovitexin (bioactive constituent) were investigated on the MCF-7 human breast cancer cell line using MTT and colony formation assay. The expression levels of proliferation-regulatory proteins were determined by western blotting. Results. Noncytotoxic concentrations of GSE significantly suppressed the proliferation of MCF-7 cells. Tumor colony formation decreased in both number and size. The level of phosphorylated AKT and β-catenin was suppressed by GSE treatment. Antiproliferation was observed in isovitexin-treated MCF-7 cells in the form of inhibited colony formation and reduced expression of phosphorylated AKT and β-catenin protein. Conclusions. This study demonstrates the novel effect of G. speciosum as an antiproliferative via suppression of the AKT/β-catenin-dependent pathway. This may prompt further investigation of this plant in breast cancer therapy.

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