scholarly journals Doxorubicin induces drug resistance and expression of the novel CD44st via NF-κB in human breast cancer MCF-7 cells

2014 ◽  
Vol 31 (6) ◽  
pp. 2735-2742 ◽  
Author(s):  
XIN JIAN FANG ◽  
HUA JIANG ◽  
YA QUN ZHU ◽  
LI YUAN ZHANG ◽  
QIU HONG FAN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Human Breast Cancer ◽  
The Novel ◽  
Human Breast ◽  
Mcf 7

Delivery of siRNA by MRI-visible nanovehicles to overcome drug resistance in MCF-7/ADR human breast cancer cells

Biomaterials ◽  
2014 ◽  
Vol 35 (35) ◽  
pp. 9495-9507 ◽  
Author(s):  
Gan Lin ◽  
Wencheng Zhu ◽  
Li Yang ◽  
Jun Wu ◽  
Bingbing Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

scholarly journals Antiproliferative Effect of Grammatophyllum speciosum Ethanolic Extract and Its Bioactive Compound on Human Breast Cancer Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Verisa Chowjarean ◽  
Kamala Sadabpod
Keyword(s):  
Breast Cancer ◽  
Colony Formation ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Ethanolic Extract ◽  
Bioactive Compound ◽  
The Novel ◽  
Human Breast ◽  
Phosphorylated Akt ◽  
Mcf 7

Background/Aim. Grammatophyllum speciosum Blume exhibits various promising pharmacological activities. However, its effect on breast cancer has not been determined. Materials and Methods. The antiproliferation effects of the G. speciosum pseudobulb ethanolic extract (GSE) and isovitexin (bioactive constituent) were investigated on the MCF-7 human breast cancer cell line using MTT and colony formation assay. The expression levels of proliferation-regulatory proteins were determined by western blotting. Results. Noncytotoxic concentrations of GSE significantly suppressed the proliferation of MCF-7 cells. Tumor colony formation decreased in both number and size. The level of phosphorylated AKT and β-catenin was suppressed by GSE treatment. Antiproliferation was observed in isovitexin-treated MCF-7 cells in the form of inhibited colony formation and reduced expression of phosphorylated AKT and β-catenin protein. Conclusions. This study demonstrates the novel effect of G. speciosum as an antiproliferative via suppression of the AKT/β-catenin-dependent pathway. This may prompt further investigation of this plant in breast cancer therapy.

Hematoporphyrin and doxorubicin co-loaded nanomicelles for the reversal of drug resistance in human breast cancer cells by combining sonodynamic therapy and chemotherapy

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 100361-100372 ◽  
Author(s):  
Guoyun Wan ◽  
Yang Liu ◽  
Shurui Shi ◽  
Bowei Chen ◽  
Yue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Sonodynamic Therapy ◽  
Mcf 7

HPDF nanomicells reversed drug resistance of MCF-7/ADR cells by combining sonodynamic therapy and chemotherapy.

scholarly journals SLCO and SLC22 Solute Carriers: Establishing Differential Expression Patterns in Human Breast Cancer Cell Lines and Tumour Samples

2021 ◽  
Author(s):  
Rachel Sutherland ◽  
Annette Meeson ◽  
Simon Lowes
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Differential Expression ◽  
Steroid Hormones ◽  
Cell Lines ◽  
Anticancer Drugs ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Slc Transporters ◽  
Mcf 7

Abstract Background: The uptake of nutrients essential for cell growth and survival is facilitated by solute carrier (SLC) transporters. The SLCO and SLC22 subfamilies mediate the uptake of substrates relevant to breast cancer (BC), including steroid hormones and anticancer drugs, and accumulating evidence suggests that altered expression of these transporters may affect BC pathogenesis by influencing cell proliferation and anticancer drug resistance. Methods: The differential expression of 11 SLCO and 14 SLC22 transporters was investigated using semi-quantitative and quantitative PCR in MCF-7 and MDA-MB-231 BC cell lines and in human BC tissue samples. Results: 8 SLCO and 10 SLC22 transporters were expressed in at least one cell line. Of these SLCO1B1, SLCO1B3, SLCO3A1, SLC22A1, SLC22A3, SLC22A4 and SLC22A16 showed higher expression in MDA-MB-231 than MCF-7 cells. Conversely, SLCO2A1, SLCO4A1, SLCO4C1, SLCO5A1, SLC22A5 showed higher expression in MCF-7 than MDA-MB-231 cells. In four human breast cancer samples, there was variable expression of the 25 SLC transporters, however, 11 SLCO and 9 SLC22 transporters were detected in at least one sample. Conclusion: BC cells express a variety of SLCs capable of transporting a range of steroid hormones and clinically relevant anticancer drugs, which could implicate them in BC pathogenesis and anti-cancer drug resistance.

Bisacylimidoselenocarbamates Cause G2/M Arrest Associated with the Modulation of CDK1 and Chk2 in Human Breast Cancer MCF-7 Cells

2013 ◽  
Vol 20 (12) ◽  
pp. 1609-1619 ◽  
Author(s):  
Iranzu Lamberto ◽  
Daniel Plano ◽  
Esther Moreno ◽  
Maria Font ◽  
Juan Antonio Palop ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Mcf 7

Design, Synthesis and Antitumor Assessment of Phenylureas Bearing 5-Fluoroindolin-2-one Moiety

2020 ◽  
Vol 16 (7) ◽  
pp. 958-968
Author(s):  
Yunrui Cai ◽  
Tong Chen ◽  
Huajian Zhu ◽  
Hongbin Zou
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Cancer ◽  
The Body ◽  
Human Breast ◽  
Design Synthesis ◽  
Human Carcinoma ◽  
Xenograft Models ◽  
New Compounds ◽  
Mcf 7

Background: The development of novel antineoplastic agents remains highly desirable. Objective: This study focuses on the design, synthesis, and antitumor evaluation of phenyl ureas bearing 5-fluoroindolin-2-one moiety. Methods: Three sets of phenylureas were designed and synthesized and their antiproliferative ability was measured against four human carcinoma cell lines (Hela, Eca-109, A549, and MCF-7) via MTT assay. In vivo anticancer activity was further evaluated in xenograft models of human breast cancer (MCF-7). Results: A total of twenty-one new compounds were synthesized and characterized by means of 1H and 13C NMR as well as HR-MS. Three sets of compounds (1a‒1c, 2a‒2c, and 3a‒3c) were initially constructed, and preliminary antiproliferative activities of these molecules were evaluated against Hela, Eca-109, A549 and MCF-7, highlighting the meta-substituted phenylureas (1a‒1c) as the most cytotoxic set. A series of meta-substituted phenylureas derivatives (1d‒1o) were then designed and synthesized for structure-activity relationship study. Most of the new compounds showed desirable cytotoxicity, among which compound 1g exhibited the most remarkable cytotoxic effects against the tested human cancer cells with IC50 values ranging from 1.47 to 6.79 μM. Further studies showed that compound 1g suppressed tumor growth in human breast cancer (MCF- 7) xenograft models without affecting the body weight of its recipients. Conclusion: In this study, twenty-one new compounds, containing the privileged structures of phenylurea and 5-fluoroindolin-2-one, were designed and synthesized. Subsequent structureactivity studies showed that 1g was the most bioactive antitumor agent among all tested compounds, hence a potentially promising lead compound once given further optimization.

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