scholarly journals Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression

1995 ◽  
Vol 72 (3) ◽  
pp. 691-695 ◽  
Author(s):  
M Mandai ◽  
I Konishi ◽  
T Komatsu ◽  
T Mori ◽  
S Arao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Carcinoma ◽  
Loss Of Heterozygosity ◽  
Gene Loss ◽  
Tumour Progression ◽  
Ras Mutation ◽  
Nm23 Gene

scholarly journals Mapping loss of heterozygosity at chromosome 13q: loss at 13q12-q13 is associated with breast tumour progression and poor prognosis

1998 ◽  
Vol 34 (13) ◽  
pp. 2076-2081 ◽  
Author(s):  
G Eiriksdottir ◽  
G Johannesdottir ◽  
S Ingvarsson ◽  
I.B Björnsdottir ◽  
J.G Jonasson ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Poor Prognosis ◽  
Tumour Progression ◽  
Breast Tumour ◽  
Chromosome 13Q

Differential gene expression identifies subgroups of ovarian carcinoma

2006 ◽  
Vol 148 (5) ◽  
pp. 223-248 ◽  
Author(s):  
Amy P.N. Skubitz ◽  
Stefan E. Pambuccian ◽  
Peter A. Argenta ◽  
Keith M. Skubitz
Keyword(s):  
Gene Expression ◽  
Ovarian Carcinoma ◽  
Differential Gene Expression ◽  
Differential Gene

scholarly journals Frequent loss of heterozygosity on chromosome 6 in human ovarian carcinoma

1993 ◽  
Vol 67 (3) ◽  
pp. 551-559 ◽  
Author(s):  
WD Foulkes ◽  
J Ragoussis ◽  
GWH Stamp ◽  
GJ Allan ◽  
J Trowsdale
Keyword(s):  
Ovarian Carcinoma ◽  
Loss Of Heterozygosity ◽  
Chromosome 6 ◽  
Human Ovarian Carcinoma

scholarly journals Integrative Omic Profiling Reveals Unique Hypoxia Induced Signatures in Gastric Cancer Associated Myofibroblasts

Cancers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 263
Author(s):  
Hanna Najgebauer ◽  
Andrew Jarnuczak ◽  
Andrea Varro ◽  
Christopher Sanderson
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Normal Tissue ◽  
Tumour Progression ◽  
Cancer Cell Migration ◽  
Hypoxic Conditions ◽  
Mechanistic Insight ◽  
Functional Characterisation ◽  
Induced Changes ◽  
Insight Into

Although hypoxia is known to contribute to several aspects of tumour progression, relatively little is known about the effects of hypoxia on cancer-associated myofibroblasts (CAMs), or the consequences that conditional changes in CAM function may have on tumour development and metastasis. To investigate this issue in the context of gastric cancer, a comparative multiomic analysis was performed on populations of patient-derived myofibroblasts, cultured under normoxic or hypoxic conditions. Data from this study reveal a novel set of CAM-specific hypoxia-induced changes in gene expression and secreted proteins. Significantly, these signatures are not observed in either patient matched adjacent tissue myofibroblasts (ATMs) or non-cancer associated normal tissue myofibroblasts (NTMs). Functional characterisation of different myofibroblast populations shows that hypoxia-induced changes in gene expression not only enhance the ability of CAMs to induce cancer cell migration, but also confer pro-tumorigenic (CAM-like) properties in NTMs. This study provides the first global mechanistic insight into the molecular changes that contribute to hypoxia-induced pro-tumorigenic changes in gastric stromal myofibroblasts.

CRYAB inhibits migration and invasion of bladder cancer cells through the PI3K/AKT and ERK pathways

2019 ◽  
Vol 50 (3) ◽  
pp. 254-260 ◽  
Author(s):  
Houxin Ruan ◽  
Yang Li ◽  
Xu Wang ◽  
Bin Sun ◽  
Weihua Fang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Tumour Progression ◽  
Tissue Microarrays ◽  
Mitogen Activated Protein Kinase ◽  
Signalling Pathways ◽  
Migration And Invasion ◽  
High Recurrence Rate ◽  
Mesenchymal Transition ◽  
Alpha Crystallin

Abstract Background Bladder cancer is a common malignancy characterized by a high recurrence rate and the development of drug resistance. Frequent mutations and gene expression alterations in the PI3K/AKT and mitogen-activated protein kinase-ERK pathways lead to deregulated cell growth and the acquisition of invasive properties, which facilitates tumour progression and confers resistance to chemotherapy. Therefore, identification of the underlying mechanisms that trigger the activation of these signalling pathways and control the invasive phenotype of tumour cells is of urgent need. Methods We utilized publicly available gene expression databases (GEO and TCGA) and bioinformatics analysis to identify key gene expression changes in human bladder cancer . The key gene expression was detected using BC tissue microarrays. Cell proliferation, apoptosis, migration, invasion and related signalling pathways were analysed flowing transfection with key gene overexpression plasmids. Results The analysis revealed that inhibited expression of the alpha-crystallin B chain was a common feature in all analysed datasets. The decrease in alpha-crystallin B expression was further confirmed at the protein level using BC tissue microarrays. Overexpression of alpha-crystallin B in T24 and J82 BC cell lines resulted in significant inhibition of tumour cell migration and invasion, which was associated with a decrease in PI3K, AKT and ERK activation. Moreover, alpha-crystallin B overexpression increased the expression of E-cadherin, while reducing the expression of N-cadherin, which indicated suppression of the epithelial–mesenchymal transition. Conclusions Overall, the results of our study suggested that alpha-crystallin B may function as a tumour-suppressive factor in bladder cancer.

Loss of heterozygosity at 1p-19q induces a global change in oligodendroglial tumor gene expression

2009 ◽  
Vol 95 (3) ◽  
pp. 343-354 ◽  
Author(s):  
Rubén Ferrer-Luna ◽  
Manuel Mata ◽  
Lina Núñez ◽  
Jorge Calvar ◽  
Francisco Dasí ◽  
...  
Keyword(s):  
Gene Expression ◽  
Global Change ◽  
Loss Of Heterozygosity ◽  
Oligodendroglial Tumor ◽  
Tumor Gene Expression ◽  
Tumor Gene
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